[Term]
id: PR:000000655
name: smad2 isoform Short acetylated and phosphorylated 1
def: "A smad2 isoform Short acetylated and phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation and acetylated in a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756]
comment: Category=modification.
synonym: "SMAD2/iso:Short/AcPhos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000575 ! smad2 isoform Short acetylated and phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000000654
name: smad2 isoform Long phosphorylated and ubiquitinated 1
def: "A smad2 isoform Long phosphorylated and ubiquitinated form that has been phosphorylated by TGF-beta receptor activation and further ubiquitinated by NEDD4L. This form is targeted for proteosomal degradation. Example: UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141]
comment: Category=modification.
synonym: "SMAD2/iso:Long/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000573 ! smad2 isoform Long phosphorylated and ubiquitinated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000000572
name: smad2 isoform Long acetylated and phosphorylated form
def: "A smad2 isoform Long that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD2/iso:Long/AcPhos+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00394 ! acetylated residue
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000468 ! smad2 isoform Long

[Term]
id: PR:000000573
name: smad2 isoform Long phosphorylated and ubiquitinated form
def: "A smad2 isoform Long that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD2/iso:Long/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000000468 ! smad2 isoform Long

[Term]
id: PR:000000574
name: smad2 isoform Long phosphorylated form
def: "A smad2 isoform Long that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD2/iso:Long/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000468 ! smad2 isoform Long

[Term]
id: PR:000000575
name: smad2 isoform Short acetylated and phosphorylated form
def: "A smad2 isoform Short that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD2/iso:Short/AcPhos+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00394 ! acetylated residue
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000469 ! smad2 isoform Short

[Term]
id: PR:000000576
name: smad2 isoform Short phosphorylated form
def: "A smad2 isoform Short that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD2/iso:Short/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000469 ! smad2 isoform Short

[Term]
id: PR:000000652
name: smad2 isoform Long phosphorylated 3
def: "A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling." [PMID:11027280]
comment: Category=modification. Note: Phosphorylation can occur at Ser and/or Thr residues.
synonym: "SMAD2/iso:Long/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000574 ! smad2 isoform Long phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q15796-2
name: mothers against decapentaplegic homolog 2 isoform Short (human)
def: "A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796]
comment: Category=organism-sequence.
synonym: "hSMAD2/iso:Short" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 isoform 2 (human)" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform 2 (human)" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform Smad2Deltaexon3 (human)" EXACT [UniProtKB:Q15796]
xref: UniProtKB:Q15796-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000469 ! smad2 isoform Short

[Term]
id: PR:O70436
name: mothers against decapentaplegic homolog 2 (rat)
def: "A smad2 that is encoded in the genome of rat." [OMA:O70436, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh2" RELATED Gene-based [UniProtKB:O70436]
synonym: "Smad2" RELATED Gene-based [UniProtKB:O70436]
synonym: "rSMAD2" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 2 (rat)" EXACT [UniProtKB:O70436]
synonym: "MAD homolog 2 (rat)" EXACT [UniProtKB:O70436]
synonym: "SMAD family member 2 (rat)" EXACT [UniProtKB:O70436]
synonym: "Mad-related protein 2 (rat)" EXACT [UniProtKB:O70436]
synonym: "mothers against DPP homolog 2 (rat)" EXACT [UniProtKB:O70436]
xref: UniProtKB:O70436
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000364 ! smad2
relationship: has_gene_template RGD:3031 ! Smad2 (rat)

[Term]
id: PR:Q62432
name: mothers against decapentaplegic homolog 2 (mouse)
def: "A smad2 that is encoded in the genome of mouse." [OMA:Q62432, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh2" RELATED Gene-based [UniProtKB:Q62432]
synonym: "Madr2" RELATED Gene-based [UniProtKB:Q62432]
synonym: "Smad2" RELATED Gene-based [UniProtKB:Q62432]
synonym: "mMad2" EXACT [UniProtKB:Q62432]
synonym: "mSMAD2" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 2 (mouse)" EXACT [UniProtKB:Q62432]
synonym: "MAD homolog 2 (mouse)" EXACT [UniProtKB:Q62432]
synonym: "SMAD family member 2 (mouse)" EXACT [UniProtKB:Q62432]
synonym: "Mad-related protein 2 (mouse)" EXACT [UniProtKB:Q62432]
synonym: "mothers against DPP homolog 2 (mouse)" EXACT [UniProtKB:Q62432]
xref: UniProtKB:Q62432
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000364 ! smad2
relationship: has_gene_template MGI:108051 ! Smad2 (mouse)

[Term]
id: PR:000000656
name: smad2 isoform Short phosphorylated 1
def: "A smad2 isoform Short phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PMID:15630024, PMID:17074756, PMID:9873005]
comment: Category=modification.
synonym: "SMAD2/iso:Short/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta receptor-activated smad2" RELATED []
is_a: PR:000000576 ! smad2 isoform Short phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000025942
name: smad2 isoform Long phosphorylated 1 (mouse)
def: "A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025976; Ser-465/Ser-467).
synonym: "mSMAD2/iso:Long/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000650 ! smad2 isoform Long phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000651
name: smad2 isoform Long phosphorylated 2
def: "A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and multiple Ser and/or Thr residues in the linker region by ERK1. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
comment: Category=modification.
synonym: "SMAD2/iso:Long/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000574 ! smad2 isoform Long phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000000650
name: smad2 isoform Long phosphorylated 1
def: "A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
comment: Category=modification.
synonym: "SMAD2/iso:Long/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TGF-beta receptor-activated smad2" RELATED []
is_a: PR:000000574 ! smad2 isoform Long phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P45896
name: dwarfin sma-3 (worm)
def: "A smad2 that is encoded in the genome of worm." [OMA:P45896, PRO:DNx]
comment: Category=organism-gene.
synonym: "cem-2" RELATED Gene-based [UniProtKB:P45896]
synonym: "sma-3" RELATED Gene-based [UniProtKB:P45896]
synonym: "R13F6.9" RELATED Gene-based [UniProtKB:P45896]
synonym: "SMAD2 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "MAD protein homolog 2 (worm)" EXACT [UniProtKB:P45896]
xref: UniProtKB:P45896
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000000364 ! smad2
relationship: has_gene_template WormBase:WBGene00004857 ! sma-3 (worm)

[Term]
id: PR:000000653
name: smad2 isoform Long phosphorylated 4
def: "A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in the oncogenic Ras-activated pathway. Example: UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]
comment: Category=modification.
synonym: "SMAD2/iso:Long/Phos:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000574 ! smad2 isoform Long phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q15796-1
name: mothers against decapentaplegic homolog 2 isoform Long (human)
def: "A smad2 isoform Long that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD2/iso:Long" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 isoform 1 (human)" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB:Q15796-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000468 ! smad2 isoform Long

[Term]
id: PR:000025960
name: smad2 isoform unphosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 2 (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif." [PMID:19135894, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "hSMAD2/iso:[Long/Short]/UnPhos:1" EXACT PRO-short-label [PRO:DAN]
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
union_of: PR:000045371 ! smad2 isoform Long unphosphorylated 1 (human)
union_of: PR:000045494 ! smad2 isoform Short unphosphorylated 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018296
name: smad2, initiator methionine removed form
def: "A smad2 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000364 ! smad2
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000025943
name: smad2 isoform Short phosphorylated 1 (mouse)
def: "A smad2 isoform Short phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025976; Ser-435/Ser-437).
synonym: "mSMAD2/iso:Short/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000656 ! smad2 isoform Short phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000045494
name: smad2 isoform Short unphosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD2/iso:Short/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q15796-2 ! mothers against decapentaplegic homolog 2 isoform Short (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026718
name: smad2 isoform Long, initiator methionine removed form
def: "A smad2 isoform Long that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD2/iso:Long/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000468 ! smad2 isoform Long
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000000468
name: smad2 isoform Long
def: "A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD2/iso:Long" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 isoform 1" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform 1" EXACT [PRO:DNx]
is_a: PR:000000364 ! smad2

[Term]
id: PR:000000469
name: smad2 isoform Short
def: "A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-2 or a 1:1 ortholog thereof." [PMID:8752209, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "exon3delta" RELATED []
synonym: "short isoform" RELATED []
synonym: "SMAD2/iso:Short" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 isoform 2" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform 2" EXACT [PRO:DNx]
is_a: PR:000000364 ! smad2

[Term]
id: PR:000036556
name: smad2 isoform Short acetylated and phosphorylated 1 (human)
def: "A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD2/iso:Short/AcPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-2, Lys-19, MOD:00394|Ser-435/Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000655 ! smad2 isoform Short acetylated and phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000036555
name: smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
def: "A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
comment: Category=organism-modification. Note: The position of the ubiquitinated residue is unknown.
synonym: "mSMAD2/iso:Long/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000654 ! smad2 isoform Long phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000036554
name: smad2 isoform Long acetylated and phosphorylated 1 (human)
def: "A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD2/iso:Long/AcPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000649 ! smad2 isoform Long acetylated and phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000049284
name: mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:Q15796, 2-467, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782774]
comment: Category=organism-modification.
synonym: "hSMAD2/InitMet-/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000090852, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q15796, 2-467, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782774 "PR:000049284 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000649
name: smad2 isoform Long acetylated and phosphorylated 1
def: "A smad2 isoform Long acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated on a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756]
comment: Category=modification.
synonym: "SMAD2/iso:Long/AcPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 sequence 1 acetylated-1 and phosphorylated-1" EXACT []
is_a: PR:000000572 ! smad2 isoform Long acetylated and phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000045371
name: smad2 isoform Long unphosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD2/iso:Long/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q15796-1 ! mothers against decapentaplegic homolog 2 isoform Long (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049283
name: mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 220, and phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009189]
comment: Category=organism-modification.
synonym: "hSMAD2/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000090852, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009189 "PR:000049283 located_in GO:0005654"
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000049282
name: mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009185, Reactome:R-HSA-3009186]
comment: Category=organism-modification.
synonym: "hSMAD2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000090852, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q15796, 2-467, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009185 "PR:000049282 located_in GO:0005654"
xref: Reactome:R-HSA-3009186 "PR:000049282 located_in GO:0005829"
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000025938
name: smad2 isoform Short phosphorylated 1 (human)
def: "A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025963; Ser-435/Ser-437).
synonym: "hSMAD2/iso:Short/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000656 ! smad2 isoform Short phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000002570
name: smad2 isoform Long unmodified form
def: "A smad2 isoform Long that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD2/iso:Long/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000468 ! smad2 isoform Long
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000002571
name: smad2 isoform Short unmodified form
def: "A smad2 isoform Short that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD2/iso:Short/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000469 ! smad2 isoform Short
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:Q62432-1
name: mothers against decapentaplegic homolog 2 isoform Long (mouse)
def: "A smad2 isoform Long that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD2/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q62432-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000468 ! smad2 isoform Long

[Term]
id: PR:Q62432-2
name: mothers against decapentaplegic homolog 2 isoform Short (mouse)
def: "A smad2 isoform Short that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q62432]
comment: Category=organism-sequence.
synonym: "mSMAD2/iso:Short" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 isoform 2 (mouse)" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform 2 (mouse)" EXACT [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 2 isoform Deltaexon3 (mouse)" EXACT [UniProtKB:Q62432]
xref: UniProtKB:Q62432-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000469 ! smad2 isoform Short

[Term]
id: PR:Q9I9P9
name: mothers against decapentaplegic homolog 2 (zebrafish)
def: "A smad2 that is encoded in the genome of zebrafish." [PRO:DNx, UniProtKB:Q9I9P9]
comment: Category=organism-gene.
synonym: "madh2" RELATED Gene-based [UniProtKB:Q9I9P9]
synonym: "smad2" RELATED Gene-based [UniProtKB:Q9I9P9]
synonym: "z-SMAD2" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad2 (zebrafish)" EXACT [UniProtKB:Q9I9P9]
synonym: "SMAD 2 (zebrafish)" EXACT [UniProtKB:Q9I9P9]
synonym: "MAD homolog 2 (zebrafish)" EXACT [UniProtKB:Q9I9P9]
synonym: "SMAD family member 2 (zebrafish)" EXACT [UniProtKB:Q9I9P9]
synonym: "mothers against DPP homolog 2 (zebrafish)" EXACT [UniProtKB:Q9I9P9]
xref: UniProtKB:Q9I9P9
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000000364 ! smad2
relationship: has_gene_template ZFIN:ZDB-GENE-990603-7 ! smad2 (zebrafish)

[Term]
id: PR:Q15796
name: mothers against decapentaplegic homolog 2 (human)
def: "A smad2 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH2" RELATED Gene-based [UniProtKB:Q15796]
synonym: "MADR2" RELATED Gene-based [UniProtKB:Q15796]
synonym: "SMAD2" RELATED Gene-based [UniProtKB:Q15796]
synonym: "hMAD-2" EXACT [UniProtKB:Q15796]
synonym: "hSMAD2" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad2 (human)" EXACT [UniProtKB:Q15796]
synonym: "JV18-1 (human)" EXACT [UniProtKB:Q15796]
synonym: "SMAD 2 (human)" EXACT [UniProtKB:Q15796]
synonym: "MAD homolog 2 (human)" EXACT [UniProtKB:Q15796]
synonym: "SMAD family member 2 (human)" EXACT [UniProtKB:Q15796]
synonym: "Mad-related protein 2 (human)" EXACT [UniProtKB:Q15796]
synonym: "mothers against DPP homolog 2 (human)" EXACT [UniProtKB:Q15796]
xref: UniProtKB:Q15796
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000364 ! smad2
relationship: has_gene_template HGNC:6768 ! SMAD2 (human)

[Term]
id: PR:000025935
name: smad2 isoform Long phosphorylated 2 (human)
def: "A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
comment: Category=organism-modification. Kinase=("MAPK3"; PR:000026189; Thr-8/Thr-220/Ser-245/Ser-250/Ser-255). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
synonym: "hSMAD2/iso:Long/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000000651 ! smad2 isoform Long phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025934
name: smad2 isoform Long phosphorylated 1 (human)
def: "A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
synonym: "hSMAD2/iso:Long/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-177099 "PR:000025934 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000650 ! smad2 isoform Long phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000025937
name: smad2 isoform Long phosphorylated 4 (human)
def: "A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]
comment: Category=organism-modification. Kinase=("MAP2K1"; PR:000026196; Thr-220/Ser-245/Ser-250/Ser-255).
synonym: "hSMAD2/iso:Long/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000653 ! smad2 isoform Long phosphorylated 4
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000025936
name: smad2 isoform Long phosphorylated 3 (human)
def: "A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]
comment: Category=organism-modification. Kinase=("CAMK-II"; PR:000003197; Ser-240). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
synonym: "hSMAD2/iso:Long/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000652 ! smad2 isoform Long phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049281
name: mothers against decapentaplegic homolog 2, initiator methionine removed form (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed. UniProtKB:Q15796, 2-467." [PRO:DNx, Reactome:R-HSA-3006352, Reactome:R-HSA-3006353]
comment: Category=organism-modification.
synonym: "PRO_0000090852" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSMAD2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796, 2-467" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3006352 "PR:000049281 located_in GO:0005654"
xref: Reactome:R-HSA-3006353 "PR:000049281 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028327
name: smad2 unmodified form
def: "A smad2 that lacks any modified amino-acid residues." [PRO:DAN]
comment: Category=modification.
synonym: "SMAD2/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000364 ! smad2
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue

[Term]
id: PR:000025973
name: smad2 isoform unmodified form
def: "A smad2 unmodified form that corresponds to either isoform Long or isoform Short." [PMID:19135894, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "SMAD2/iso:[Long/Short]/UnMod" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000028327 ! smad2 unmodified form
union_of: PR:000002570 ! smad2 isoform Long unmodified form
union_of: PR:000002571 ! smad2 isoform Short unmodified form

[Term]
id: PR:000050145
name: smad2 phosphorylated 1 (human)
def: "A smad2 phosphorylated 1 in human. This form is phosphorylated in the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
synonym: "hSMAD2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000050146 ! smad2 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000364
name: smad2
def: "A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof." [PMID:9311995]
comment: Category=gene.
synonym: "Mad2" EXACT []
synonym: "MAD-2" EXACT []
synonym: "MADH2" RELATED Gene-based []
synonym: "MADR2" RELATED Gene-based []
synonym: "SMAD2" EXACT PRO-short-label [PRO:DNx]
synonym: "JV18-1" EXACT []
synonym: "SMAD 2" EXACT []
synonym: "MAD homolog 2" EXACT []
synonym: "SMAD family member 2" EXACT []
synonym: "Mad-related protein 2" EXACT []
synonym: "mothers against DPP homolog 2" EXACT []
is_a: PR:000000066 ! TGF-beta receptor-regulated smad protein

[Term]
id: PR:000036482
name: smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
def: "A smad2 isoform Long phosphorylated and ubiquitinated form in mouse. UniProtKB:Q62432-1, MOD:00696|MOD:01148." [PMID:15496141, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD2/iso:Long/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62432-1, MOD:00696|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000573 ! smad2 isoform Long phosphorylated and ubiquitinated form
relationship: has_part MOD:00696 ! phosphorylated residue
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000000471
name: smad2 sequence variant L440R (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has an Arg residue at the position equivalent to Leu-440 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952." [PMID:8752209, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hSMAD2/var:L440R" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 sequence variant 2 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Leu-440, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011377
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000470
name: smad2 sequence variant R133C (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has a Cys residue at the position equivalent to Arg-133 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950." [PMID:8752209, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hSMAD2/var:R133C" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 sequence variant 1 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Arg-133, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011375
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000473
name: smad2 sequence variant D450E (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has a Glu residue at the position equivalent to Asp-450 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972." [PMID:8752209, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hSMAD2/var:D450E" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 sequence variant 4 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Asp-450, CHEBI:29972" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011379
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000472
name: smad2 sequence variant P445H (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has a His residue at the position equivalent to Pro-445 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979." [PMID:8752209, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hSMAD2/var:P445H" EXACT PRO-short-label [PRO:DNx]
synonym: "smad2 sequence variant 3 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q15796-1, Pro-445, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011378
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000474
name: smad2 sequence variant 5 (human)
def: "A mothers against decapentaplegic homolog 2 (human) that has a fifteen-residue deletion at the position equivalent to region 344-358 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, 2-343, 359-467." [PMID:8673135, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hSMAD2/var:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q15796-1, 2-343, 359-467" NARROW PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011376
is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000050146
name: smad2 phosphorylated 1
def: "A smad2 that has been phosphorylated on the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796, Ser-465/Ser-467, MOD:00046." [PRO:DAN]
comment: Category=modification.
synonym: "SMAD2/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "TGF-beta receptor-activated smad2" EXACT []
is_a: PR:000000364 ! smad2
relationship: has_part MOD:00046 ! O-phospho-L-serine