[Term] id: PR:Q15796-2 name: mothers against decapentaplegic homolog 2 isoform Short (human) def: "A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796] comment: Category=organism-sequence. synonym: "hSMAD2/iso:Short" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 isoform 2 (human)" EXACT [PRO:DNx] synonym: "mothers against decapentaplegic homolog 2 isoform 2 (human)" EXACT [PRO:DNx] synonym: "mothers against decapentaplegic homolog 2 isoform Smad2Deltaexon3 (human)" EXACT [UniProtKB:Q15796] xref: UniProtKB:Q15796-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000469 ! smad2 isoform Short [Term] id: PR:Q15796-1 name: mothers against decapentaplegic homolog 2 isoform Long (human) def: "A smad2 isoform Long that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSMAD2/iso:Long" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 isoform 1 (human)" EXACT [PRO:DNx] synonym: "mothers against decapentaplegic homolog 2 isoform 1 (human)" EXACT [PRO:DNx] xref: UniProtKB:Q15796-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000468 ! smad2 isoform Long [Term] id: PR:000045371 name: smad2 isoform Long unphosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD2/iso:Long/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q15796-1 ! mothers against decapentaplegic homolog 2 isoform Long (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000025960 name: smad2 isoform unphosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 2 (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif." [PMID:19135894, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hSMAD2/iso:[Long/Short]/UnPhos:1" EXACT PRO-short-label [PRO:DAN] is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) union_of: PR:000045371 ! smad2 isoform Long unphosphorylated 1 (human) union_of: PR:000045494 ! smad2 isoform Short unphosphorylated 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045494 name: smad2 isoform Short unphosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD2/iso:Short/UnPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q15796-2 ! mothers against decapentaplegic homolog 2 isoform Short (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036556 name: smad2 isoform Short acetylated and phosphorylated 1 (human) def: "A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD2/iso:Short/AcPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-2, Lys-19, MOD:00394|Ser-435/Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000655 ! smad2 isoform Short acetylated and phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000036554 name: smad2 isoform Long acetylated and phosphorylated 1 (human) def: "A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD2/iso:Long/AcPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000649 ! smad2 isoform Long acetylated and phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000049284 name: mothers against decapentaplegic homolog 2, initiator methionine removed ubiquitinated form (human) def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:Q15796, 2-467, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782774] comment: Category=organism-modification. synonym: "hSMAD2/InitMet-/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000090852, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q15796, 2-467, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6782774 "PR:000049284 located_in GO:0005829" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049281 name: mothers against decapentaplegic homolog 2, initiator methionine removed form (human) def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed. UniProtKB:Q15796, 2-467." [PRO:DNx, Reactome:R-HSA-3006352, Reactome:R-HSA-3006353] comment: Category=organism-modification. synonym: "PRO_0000090852" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hSMAD2/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796, 2-467" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3006352 "PR:000049281 located_in GO:0005654" xref: Reactome:R-HSA-3006353 "PR:000049281 located_in GO:0005829" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049283 name: mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 5 (human) def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 220, and phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009189] comment: Category=organism-modification. synonym: "hSMAD2/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000090852, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q15796, 2-467, Thr-220, MOD:00047|Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3009189 "PR:000049283 located_in GO:0005654" is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000049282 name: mothers against decapentaplegic homolog 2, initiator methionine removed phosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:Q15796. UniProtKB:Q15796, 2-467, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009185, Reactome:R-HSA-3009186] comment: Category=organism-modification. synonym: "hSMAD2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000090852, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q15796, 2-467, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3009185 "PR:000049282 located_in GO:0005654" xref: Reactome:R-HSA-3009186 "PR:000049282 located_in GO:0005829" is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000025938 name: smad2 isoform Short phosphorylated 1 (human) def: "A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA] comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025963; Ser-435/Ser-437). synonym: "hSMAD2/iso:Short/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000656 ! smad2 isoform Short phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:Q15796 name: mothers against decapentaplegic homolog 2 (human) def: "A smad2 that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "MADH2" RELATED Gene-based [UniProtKB:Q15796] synonym: "MADR2" RELATED Gene-based [UniProtKB:Q15796] synonym: "SMAD2" RELATED Gene-based [UniProtKB:Q15796] synonym: "hMAD-2" EXACT [UniProtKB:Q15796] synonym: "hSMAD2" EXACT PRO-short-label [PRO:DNx] synonym: "Smad2 (human)" EXACT [UniProtKB:Q15796] synonym: "JV18-1 (human)" EXACT [UniProtKB:Q15796] synonym: "SMAD 2 (human)" EXACT [UniProtKB:Q15796] synonym: "MAD homolog 2 (human)" EXACT [UniProtKB:Q15796] synonym: "SMAD family member 2 (human)" EXACT [UniProtKB:Q15796] synonym: "Mad-related protein 2 (human)" EXACT [UniProtKB:Q15796] synonym: "mothers against DPP homolog 2 (human)" EXACT [UniProtKB:Q15796] xref: UniProtKB:Q15796 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000364 ! smad2 relationship: has_gene_template HGNC:6768 ! SMAD2 (human) [Term] id: PR:000025935 name: smad2 isoform Long phosphorylated 2 (human) def: "A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595] comment: Category=organism-modification. Kinase=("MAPK3"; PR:000026189; Thr-8/Thr-220/Ser-245/Ser-250/Ser-255). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467). synonym: "hSMAD2/iso:Long/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000000651 ! smad2 isoform Long phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000025934 name: smad2 isoform Long phosphorylated 1 (human) def: "A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966] comment: Category=organism-modification. Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467). synonym: "hSMAD2/iso:Long/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-177099 "PR:000025934 located_in GO:0005654" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000650 ! smad2 isoform Long phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000025937 name: smad2 isoform Long phosphorylated 4 (human) def: "A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981] comment: Category=organism-modification. Kinase=("MAP2K1"; PR:000026196; Thr-220/Ser-245/Ser-250/Ser-255). synonym: "hSMAD2/iso:Long/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000653 ! smad2 isoform Long phosphorylated 4 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000025936 name: smad2 isoform Long phosphorylated 3 (human) def: "A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280] comment: Category=organism-modification. Kinase=("CAMK-II"; PR:000003197; Ser-240). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467). synonym: "hSMAD2/iso:Long/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:000000652 ! smad2 isoform Long phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000364 name: smad2 def: "A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD2 gene or a 1:1 ortholog thereof." [PMID:9311995] comment: Category=gene. synonym: "Mad2" EXACT [] synonym: "MAD-2" EXACT [] synonym: "MADH2" RELATED Gene-based [] synonym: "MADR2" RELATED Gene-based [] synonym: "SMAD2" EXACT PRO-short-label [PRO:DNx] synonym: "JV18-1" EXACT [] synonym: "SMAD 2" EXACT [] synonym: "MAD homolog 2" EXACT [] synonym: "SMAD family member 2" EXACT [] synonym: "Mad-related protein 2" EXACT [] synonym: "mothers against DPP homolog 2" EXACT [] is_a: PR:000000066 ! TGF-beta receptor-regulated smad protein [Term] id: PR:000000471 name: smad2 sequence variant L440R (human) def: "A mothers against decapentaplegic homolog 2 (human) that has an Arg residue at the position equivalent to Leu-440 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Leu-440, CHEBI:29952." [PMID:8752209, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD2/var:L440R" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 sequence variant 2 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q15796-1, Leu-440, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011377 is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000470 name: smad2 sequence variant R133C (human) def: "A mothers against decapentaplegic homolog 2 (human) that has a Cys residue at the position equivalent to Arg-133 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Arg-133, CHEBI:29950." [PMID:8752209, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD2/var:R133C" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q15796-1, Arg-133, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011375 is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000473 name: smad2 sequence variant D450E (human) def: "A mothers against decapentaplegic homolog 2 (human) that has a Glu residue at the position equivalent to Asp-450 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Asp-450, CHEBI:29972." [PMID:8752209, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD2/var:D450E" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 sequence variant 4 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q15796-1, Asp-450, CHEBI:29972" NARROW PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011379 is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000472 name: smad2 sequence variant P445H (human) def: "A mothers against decapentaplegic homolog 2 (human) that has a His residue at the position equivalent to Pro-445 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, Pro-445, CHEBI:29979." [PMID:8752209, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD2/var:P445H" EXACT PRO-short-label [PRO:DNx] synonym: "smad2 sequence variant 3 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q15796-1, Pro-445, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011378 is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000474 name: smad2 sequence variant 5 (human) def: "A mothers against decapentaplegic homolog 2 (human) that has a fifteen-residue deletion at the position equivalent to region 344-358 of the amino acid sequence represented by UniProtKB:Q15796-1. Example: UniProtKB:Q15796-1, 2-343, 359-467." [PMID:8673135, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD2/var:5" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15796-1, 2-343, 359-467" NARROW PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011376 is_a: PR:Q15796 ! mothers against decapentaplegic homolog 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens