[Term]
id: PR:000029962
name: smad5 isoform 2 (human)
def: "A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence. Note: There is no sequence deposited in any database for this form.
synonym: "hSMAD5/iso:2" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000478 ! smad5 isoform 2

[Term]
id: PR:000049290
name: mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]
comment: Category=organism-modification.
synonym: "hSMAD5/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000090865, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201432 "PR:000049290 located_in GO:0005654"
xref: Reactome:R-HSA-201473 "PR:000049290 located_in GO:0005829"
is_a: PR:Q99717 ! mothers against decapentaplegic homolog 5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000049289
name: mothers against decapentaplegic homolog 5, initiator methionine removed form (human)
def: "A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]
comment: Category=organism-modification.
synonym: "PRO_0000090865" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSMAD5/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99717, 2-465" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201431 "PR:000049289 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q99717 ! mothers against decapentaplegic homolog 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036562
name: smad5 isoform 1 phosphorylated 1 (human)
def: "A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD5/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000661 ! smad5 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q99717
name: mothers against decapentaplegic homolog 5 (human)
def: "A smad5 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH5" RELATED Gene-based [UniProtKB:Q99717]
synonym: "SMAD5" RELATED Gene-based [UniProtKB:Q99717]
synonym: "hSMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "hSmad5" EXACT [UniProtKB:Q99717]
synonym: "JV5-1 (human)" EXACT [UniProtKB:Q99717]
synonym: "Smad5 (human)" EXACT [UniProtKB:Q99717]
synonym: "SMAD 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "MAD homolog 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "SMAD family member 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "mothers against DPP homolog 5 (human)" EXACT [UniProtKB:Q99717]
xref: UniProtKB:Q99717
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template HGNC:6771 ! SMAD5 (human)

[Term]
id: PR:000000372
name: smad5
def: "A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof." [PMID:10708949]
comment: Category=gene.
synonym: "Dwf-C" EXACT []
synonym: "JV5-1" EXACT []
synonym: "MADH5" RELATED Gene-based []
synonym: "SMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad5" EXACT []
synonym: "SMAD 5" EXACT []
synonym: "dwarfin-C" EXACT []
synonym: "MAD homolog 5" EXACT []
synonym: "SMAD family member 5" EXACT []
synonym: "mothers against DPP homolog 5" EXACT []
is_a: PR:000000038 ! BMP receptor-regulated smad protein

[Term]
id: PR:Q99717-1
name: mothers against decapentaplegic homolog 5 isoform 1 (human)
def: "A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99717-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000477 ! smad5 isoform 1