[Term]
id: PR:000000373
name: smad6
def: "An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940]
comment: Category=gene.
synonym: "MADH6" RELATED Gene-based []
synonym: "Madh7" RELATED Gene-based []
synonym: "SMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Msmad6" RELATED Gene-based []
synonym: "SMAD 6" EXACT []
synonym: "MAD homolog 6" EXACT []
synonym: "Mad homolog 7" EXACT []
synonym: "SMAD family member 6" EXACT []
synonym: "mothers against DPP homolog 6" EXACT []
is_a: PR:000000099 ! inhibitory smad protein

[Term]
id: PR:O43541-2
name: mothers against decapentaplegic homolog 6 isoform B (human)
def: "A smad6 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "mothers against decapentaplegic homolog 6 isoform Smad 6S (human)" EXACT [UniProtKB:O43541]
xref: UniProtKB:O43541-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000480 ! smad6 isoform 2

[Term]
id: PR:O43541-4
name: mothers against decapentaplegic homolog 6 isoform D (human)
def: "A mothers against decapentaplegic homolog 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43541-4." [PRO:DNx, UniProtKB:O43541]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:D" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43541-4
is_a: PR:O43541 ! mothers against decapentaplegic homolog 6 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43541
name: mothers against decapentaplegic homolog 6 (human)
def: "A smad6 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH6" RELATED Gene-based [UniProtKB:O43541]
synonym: "SMAD6" RELATED Gene-based [UniProtKB:O43541]
synonym: "hSMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad6 (human)" EXACT [UniProtKB:O43541]
synonym: "SMAD 6 (human)" EXACT [UniProtKB:O43541]
synonym: "MAD homolog 6 (human)" EXACT [UniProtKB:O43541]
synonym: "SMAD family member 6 (human)" EXACT [UniProtKB:O43541]
synonym: "mothers against DPP homolog 6 (human)" EXACT [UniProtKB:O43541]
xref: Reactome:R-HSA-3006350 "PR:O43541 located_in GO:0005829"
xref: UniProtKB:O43541
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000373 ! smad6
relationship: has_gene_template HGNC:6772 ! SMAD6 (human)

[Term]
id: PR:O43541-1
name: mothers against decapentaplegic homolog 6 isoform A (human)
def: "A smad6 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD6/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43541-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000479 ! smad6 isoform 1