[Term]
id: PR:O15105-3
name: mothers against decapentaplegic homolog 7 isoform 3 (human)
def: "A smad7 isoform 3 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038037 ! smad7 isoform 3

[Term]
id: PR:O15105-2
name: mothers against decapentaplegic homolog 7 isoform h2 (human)
def: "A mothers against decapentaplegic homolog 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15105-2." [PRO:DNx, UniProtKB:O15105]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-2
is_a: PR:O15105 ! mothers against decapentaplegic homolog 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O15105-1
name: mothers against decapentaplegic homolog 7 isoform 1 (human)
def: "A smad7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD7/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15105-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:O15105
name: mothers against decapentaplegic homolog 7 (human)
def: "A smad7 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH7" RELATED Gene-based [UniProtKB:O15105]
synonym: "MADH8" RELATED Gene-based [UniProtKB:O15105]
synonym: "SMAD7" RELATED Gene-based [UniProtKB:O15105]
synonym: "hSMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad7 (human)" EXACT [UniProtKB:O15105]
synonym: "SMAD 7 (human)" EXACT [UniProtKB:O15105]
synonym: "MAD homolog 7 (human)" EXACT [UniProtKB:O15105]
synonym: "MAD homolog 8 (human)" EXACT [UniProtKB:O15105]
synonym: "SMAD family member 7 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against DPP homolog 7 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against DPP homolog 8 (human)" EXACT [UniProtKB:O15105]
synonym: "mothers against decapentaplegic homolog 8 (human)" EXACT [UniProtKB:O15105]
xref: Reactome:R-HSA-173478 "PR:O15105 located_in GO:0005829"
xref: Reactome:R-HSA-178197 "PR:O15105 located_in GO:0005654"
xref: UniProtKB:O15105
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000374 ! smad7
relationship: has_gene_template HGNC:6773 ! SMAD7 (human)

[Term]
id: PR:000036566
name: smad7 isoform 1 phosphorylated 1 (human)
def: "A smad7 isoform 1 phosphorylated 1 in human. UniProtKB:O15105-1, Ser-249, MOD:00046." [PRO:CNA]
comment: Category=organism-modification. Evidence:(ECO:0000250, based on PR:000036932).
synonym: "hSMAD7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15105-1, Ser-249, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000664 ! smad7 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000374
name: smad7
def: "An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling." [PMID:17438144]
comment: Category=gene.
synonym: "MADH7" RELATED Gene-based []
synonym: "MADH8" RELATED Gene-based []
synonym: "SMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7" EXACT []
synonym: "MAD homolog 7" EXACT []
synonym: "MAD homolog 8" EXACT []
synonym: "SMAD family member 7" EXACT []
synonym: "mothers against DPP homolog 7" EXACT []
synonym: "mothers against DPP homolog 8" EXACT []
synonym: "mothers against decapentaplegic homolog 8" EXACT []
is_a: PR:000000099 ! inhibitory smad protein

[Term]
id: PR:000036565
name: smad7 isoform 1 acetylated 1 (human)
def: "A smad7 isoform 1 acetylated 1 in human. UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064." [PMID:12408818, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD7/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000663 ! smad7 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine