[Term]
id: PR:000049802
name: mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
def: "A mothers against decapentaplegic homolog 7 isoform A (mouse) that lacks a monomethylated Lys at position 70. UniProtKB:O35253-1, Lys-70, PR:000026291." [PMID:27292644, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27292644).
synonym: "mSMAD7/iso:A/UnMe:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mSMAD7 isoform A unmethylated 1" EXACT []
synonym: "UniProtKB:O35253-1, Lys-70, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35253-1 ! mothers against decapentaplegic homolog 7 isoform A (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O35253
name: mothers against decapentaplegic homolog 7 (mouse)
def: "A smad7 that is encoded in the genome of mouse." [OMA:O35253, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh7" RELATED Gene-based [UniProtKB:O35253]
synonym: "Madh8" RELATED Gene-based [UniProtKB:O35253]
synonym: "Smad7" RELATED Gene-based [UniProtKB:O35253]
synonym: "mSMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "MAD homolog 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "MAD homolog 8 (mouse)" EXACT [UniProtKB:O35253]
synonym: "SMAD family member 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against DPP homolog 7 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against DPP homolog 8 (mouse)" EXACT [UniProtKB:O35253]
synonym: "mothers against decapentaplegic homolog 8 (mouse)" EXACT [UniProtKB:O35253]
xref: UniProtKB:O35253
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000374 ! smad7
relationship: has_gene_template MGI:1100518 ! Smad7 (mouse)

[Term]
id: PR:000049801
name: mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
def: "A mothers against decapentaplegic homolog 7 isoform A (mouse) that has been monomethylated at the position equivalent to Lys-70. UniProtKB:O35253-1, Lys-70, MOD:00085." [PMID:27292644, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27292644). Methylase=("Setd7"; PR:Q8VHL1, Lys-70).
synonym: "mSMAD7/iso:A/Me1:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mSMAD7 isoform A K70 methylated" EXACT []
synonym: "UniProtKB:O35253-1, Lys-70, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O35253-1 ! mothers against decapentaplegic homolog 7 isoform A (mouse)
relationship: has_part MOD:00085 ! N6-methyl-L-lysine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000036932
name: smad7 isoform 1 phosphorylated 1 (mouse)
def: "A smad7 isoform 1 phosphorylated 1 in mouse. UniProtKB:O35253-1, Ser-249, MOD:00046." [PMID:11278814, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35253-1, Ser-249, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000664 ! smad7 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:O35253-2
name: mothers against decapentaplegic homolog 7 isoform B (mouse)
def: "A smad7 isoform 3 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mSMAD7/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35253-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000038037 ! smad7 isoform 3

[Term]
id: PR:O35253-1
name: mothers against decapentaplegic homolog 7 isoform A (mouse)
def: "A smad7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD7/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35253-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000481 ! smad7 isoform 1

[Term]
id: PR:000000374
name: smad7
def: "An inhibitory smad protein that is a translation product of the human SMAD7 gene or a 1:1 ortholog thereof. Smad7 is a negative regulator of TGF-beta signaling." [PMID:17438144]
comment: Category=gene.
synonym: "MADH7" RELATED Gene-based []
synonym: "MADH8" RELATED Gene-based []
synonym: "SMAD7" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 7" EXACT []
synonym: "MAD homolog 7" EXACT []
synonym: "MAD homolog 8" EXACT []
synonym: "SMAD family member 7" EXACT []
synonym: "mothers against DPP homolog 7" EXACT []
synonym: "mothers against DPP homolog 8" EXACT []
synonym: "mothers against decapentaplegic homolog 8" EXACT []
is_a: PR:000000099 ! inhibitory smad protein