[Term]
id: PR:000000686
name: cGMP-gated cation channel alpha-1
def: "A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]
comment: Category=gene.
synonym: "CNCG" RELATED Gene-based []
synonym: "CNG1" EXACT []
synonym: "CNCG1" RELATED Gene-based []
synonym: "CNG-1" EXACT []
synonym: "CNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated channel alpha-1" EXACT []
synonym: "cyclic nucleotide-gated cation channel 1" EXACT []
synonym: "cyclic nucleotide-gated channel, photoreceptor" EXACT []
synonym: "rod photoreceptor cGMP-gated channel subunit alpha" EXACT []
xref: IUPHARobj:394
is_a: PR:000000673 ! cyclic nucleotide-gated channel alpha subunit

[Term]
id: PR:000000738
name: cGMP-gated cation channel alpha-1 sequence variant S320F (human)
def: "A cGMP-gated cation channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCNGA1/var:S320F" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P29973-1, Ser-320, CHEBI:29997" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "cGMP-gated cation channel alpha-1 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_009297
is_a: PR:P29973 ! cGMP-gated cation channel alpha-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P29973-1
name: cGMP-gated cation channel alpha-1 isoform 1 (human)
def: "A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCNGA1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P29973-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000737 ! cGMP-gated cation channel alpha-1 isoform 1

[Term]
id: PR:P29973
name: cGMP-gated cation channel alpha-1 (human)
def: "A cGMP-gated cation channel alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29973]
comment: Category=organism-gene.
synonym: "CNCG" RELATED Gene-based [UniProtKB:P29973]
synonym: "CNCG1" RELATED Gene-based [UniProtKB:P29973]
synonym: "CNGA1" RELATED Gene-based [UniProtKB:P29973]
synonym: "hCNGA1" EXACT PRO-short-label [PRO:DNx]
synonym: "CNG1 (human)" EXACT [UniProtKB:P29973]
synonym: "CNG-1 (human)" EXACT [UniProtKB:P29973]
synonym: "CNG channel alpha-1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated channel alpha-1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated cation channel 1 (human)" EXACT [UniProtKB:P29973]
synonym: "cyclic nucleotide-gated channel, photoreceptor (human)" EXACT [UniProtKB:P29973]
synonym: "rod photoreceptor cGMP-gated channel subunit alpha (human)" EXACT [UniProtKB:P29973]
xref: Reactome:R-HSA-52425 "PR:P29973 located_in GO:0005886"
xref: DTO:01100085
xref: UniProtKB:P29973
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000686 ! cGMP-gated cation channel alpha-1
relationship: has_gene_template HGNC:2148 ! CNGA1 (human)