[Term] id: PR:O15554-1 name: intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human) def: "An intermediate conductance calcium-activated potassium channel protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hKCNN4/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O15554-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000753 ! intermediate conductance calcium-activated potassium channel protein 4 isoform 1 [Term] id: PR:O15554 name: intermediate conductance calcium-activated potassium channel protein 4 (human) def: "An intermediate conductance calcium-activated potassium channel protein 4 that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "IK1" RELATED Gene-based [UniProtKB:O15554] synonym: "SK4" RELATED Gene-based [UniProtKB:O15554] synonym: "KCA4" RELATED Gene-based [UniProtKB:O15554] synonym: "IKCA1" RELATED Gene-based [UniProtKB:O15554] synonym: "KCNN4" RELATED Gene-based [UniProtKB:O15554] synonym: "hIKCa1" EXACT [PRO:DAN, PMID:10026195] synonym: "hKCNN4" EXACT PRO-short-label [PRO:DNx] synonym: "SKCa4 (human)" EXACT [UniProtKB:O15554] synonym: "KCa3.1 (human)" EXACT [UniProtKB:O15554] synonym: "SKCa 4 (human)" EXACT [UniProtKB:O15554] synonym: "putative Gardos channel (human)" EXACT [UniProtKB:O15554] xref: Reactome:R-HSA-977543 "PR:O15554 located_in GO:0005886" xref: DTO:01100231 xref: UniProtKB:O15554 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000700 ! intermediate conductance calcium-activated potassium channel protein 4 relationship: has_gene_template HGNC:6293 ! KCNN4 (human) [Term] id: PR:000000700 name: intermediate conductance calcium-activated potassium channel protein 4 def: "A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042] comment: Category=gene. synonym: "IK1" RELATED Gene-based [] synonym: "SK4" RELATED Gene-based [] synonym: "KCA4" RELATED Gene-based [] synonym: "KCa4" EXACT [] synonym: "IKCA1" RELATED Gene-based [] synonym: "IKCa1" EXACT [] synonym: "KCNN4" EXACT PRO-short-label [PRO:DNx] synonym: "SKCa4" EXACT [] synonym: "KCa3.1" EXACT [] synonym: "SKCa 4" EXACT [] synonym: "putative Gardos channel" EXACT [] xref: IUPHARobj:384 is_a: PR:000000668 ! calcium-activated calmodulin-binding potassium channel alpha subunit