[Term]
id: PR:000046076
name: WW domain-containing oxidoreductase phosphorylated 1 (human)
def: "A WW domain-containing oxidoreductase (human) that has been phosphorylated on the residue at the position equivalent to Tyr-33 of the amino acid sequence represented by UniProtKB:Q9NZC7-1. Example: UniProtKB:Q9NZC7-1, Tyr-33, MOD:00048." [PMID:15070730, iPTMnet:Q9NZC7]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15070730). Status=unreviewed.
synonym: "hWWOX/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NZC7-1, Tyr-33, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9NZC7 ! WW domain-containing oxidoreductase (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NZC7-1
name: WW domain-containing oxidoreductase isoform 1 (human)
def: "A WW domain-containing oxidoreductase isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform FOR2 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform FOR II (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WWOXv1 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WWOX v8 (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001037 ! WW domain-containing oxidoreductase isoform 1

[Term]
id: PR:Q9NZC7-2
name: WW domain-containing oxidoreductase isoform 2 (human)
def: "A WW domain-containing oxidoreductase isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform FOR1 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WOX2 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform FOR I (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WWOXv2 (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001053 ! WW domain-containing oxidoreductase isoform 2

[Term]
id: PR:Q9NZC7-3
name: WW domain-containing oxidoreductase isoform 3 (human)
def: "A WW domain-containing oxidoreductase isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform FOR3 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WOX3 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform FOR III (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001054 ! WW domain-containing oxidoreductase isoform 3

[Term]
id: PR:Q9NZC7-4
name: WW domain-containing oxidoreductase isoform 4 (human)
def: "A WW domain-containing oxidoreductase isoform 4 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:4" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform FOR IV (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001055 ! WW domain-containing oxidoreductase isoform 4

[Term]
id: PR:Q9NZC7-5
name: WW domain-containing oxidoreductase isoform 5 (human)
def: "A WW domain-containing oxidoreductase isoform 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NZC7]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform WWOXv4 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WWOXdelta6-8 (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001056 ! WW domain-containing oxidoreductase isoform 5

[Term]
id: PR:Q9NZC7-6
name: WW domain-containing oxidoreductase isoform 6 (human)
def: "A WW domain-containing oxidoreductase isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9NZC7]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:6" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform WWOXv3 (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "WW domain-containing oxidoreductase isoform WWOXdelta5-8 (human)" EXACT [UniProtKB:Q9NZC7]
xref: UniProtKB:Q9NZC7-6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001057 ! WW domain-containing oxidoreductase isoform 6

[Term]
id: PR:Q9NZC7-7
name: WW domain-containing oxidoreductase isoform h7 (human)
def: "A WW domain-containing oxidoreductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-7." [PRO:DNx, UniProtKB:Q9NZC7]
comment: Category=organism-sequence.
synonym: "hWWOX/iso:h7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NZC7-7
is_a: PR:Q9NZC7 ! WW domain-containing oxidoreductase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NZC7
name: WW domain-containing oxidoreductase (human)
def: "A WW domain-containing oxidoreductase that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NZC7]
comment: Category=organism-gene.
synonym: "FOR" RELATED Gene-based [UniProtKB:Q9NZC7]
synonym: "WOX1" RELATED Gene-based [UniProtKB:Q9NZC7]
synonym: "WWOX" RELATED Gene-based [UniProtKB:Q9NZC7]
synonym: "hWWOX" EXACT PRO-short-label [PRO:DNx]
synonym: "SDR41C1" RELATED Gene-based [UniProtKB:Q9NZC7]
synonym: "fragile site FRA16D oxidoreductase (human)" EXACT [UniProtKB:Q9NZC7]
synonym: "short chain dehydrogenase/reductase family 41C member 1 (human)" EXACT [UniProtKB:Q9NZC7]
xref: Reactome:R-HSA-1253335 "PR:Q9NZC7 located_in GO:0005829"
xref: UniProtKB:Q9NZC7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001036 ! WW domain-containing oxidoreductase
relationship: has_gene_template HGNC:12799 ! WWOX (human)

[Term]
id: PR:Q91WL8-2
name: WW domain-containing oxidoreductase isoform m2 (mouse)
def: "A WW domain-containing oxidoreductase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WL8-2." [PRO:DNx, UniProtKB:Q91WL8]
comment: Category=organism-sequence.
synonym: "mWWOX/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WL8-2
is_a: PR:Q91WL8 ! WW domain-containing oxidoreductase (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q91WL8-3
name: WW domain-containing oxidoreductase isoform m3 (mouse)
def: "A WW domain-containing oxidoreductase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WL8-3." [PRO:DNx, UniProtKB:Q91WL8]
comment: Category=organism-sequence.
synonym: "mWWOX/iso:m3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WL8-3
is_a: PR:Q91WL8 ! WW domain-containing oxidoreductase (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q91WL8-1
name: WW domain-containing oxidoreductase isoform 1 (mouse)
def: "A WW domain-containing oxidoreductase isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mWWOX/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "WW domain-containing oxidoreductase isoform Wox1 (mouse)" EXACT [UniProtKB:Q91WL8]
xref: UniProtKB:Q91WL8-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001037 ! WW domain-containing oxidoreductase isoform 1

[Term]
id: PR:Q91WL8-4
name: WW domain-containing oxidoreductase isoform m4 (mouse)
def: "A WW domain-containing oxidoreductase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91WL8-4." [PRO:DNx, UniProtKB:Q91WL8]
comment: Category=organism-sequence.
synonym: "mWWOX/iso:m4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WL8-4
is_a: PR:Q91WL8 ! WW domain-containing oxidoreductase (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000001057
name: WW domain-containing oxidoreductase isoform 6
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-6 or a 1:1 ortholog thereof. This form contains an alternative sequence after the two WW domains and the predicted nucleotide binding site, as compared to isoform 1. Originated by exons deletions and frameshift." [PMID:11719429]
comment: Category=sequence.
synonym: "WWOX/iso:6" EXACT PRO-short-label [PRO:DNx]
synonym: "WWOXdelta5-8" RELATED []
is_a: PR:000001036 ! WW domain-containing oxidoreductase

[Term]
id: PR:000002696
name: WW domain-containing oxidoreductase isoform 1 unmodified form
def: "A WW domain-containing oxidoreductase isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "WWOX/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001037 ! WW domain-containing oxidoreductase isoform 1
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:Q9VLU5
name: WW domain-containing oxidoreductase (fruit fly)
def: "A WW domain-containing oxidoreductase that is encoded in the genome of fruit fly." [OMA:Q9VLU5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Wwox" RELATED Gene-based [UniProtKB:Q9VLU5]
synonym: "CG7221" RELATED Gene-based [UniProtKB:Q9VLU5]
synonym: "fly-WWOX" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9VLU5
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001036 ! WW domain-containing oxidoreductase
relationship: has_gene_template FlyBase:FBgn0031972 ! Wwox (fruit fly)

[Term]
id: PR:Q803A8
name: WW domain-containing oxidoreductase (zebrafish)
def: "A WW domain-containing oxidoreductase that is encoded in the genome of zebrafish." [PANTHER:PTHR24316:SF99, PRO:DNx]
comment: Category=organism-gene.
synonym: "wwox" RELATED Gene-based [UniProtKB:Q803A8]
synonym: "z-WWOX" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q803A8
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000001036 ! WW domain-containing oxidoreductase
relationship: has_gene_template ZFIN:ZDB-GENE-040426-858 ! wwox (zebrafish)

[Term]
id: PR:Q91WL8
name: WW domain-containing oxidoreductase (mouse)
def: "A WW domain-containing oxidoreductase that is encoded in the genome of mouse." [OMA:Q91WL8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Wox1" RELATED Gene-based [UniProtKB:Q91WL8]
synonym: "Wwox" RELATED Gene-based [UniProtKB:Q91WL8]
synonym: "mWWOX" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q91WL8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001036 ! WW domain-containing oxidoreductase
relationship: has_gene_template MGI:1931237 ! Wwox (mouse)

[Term]
id: PR:000001036
name: WW domain-containing oxidoreductase
def: "A protein that is a translation product of the human WWOX gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "FOR" RELATED Gene-based []
synonym: "WOX1" RELATED Gene-based []
synonym: "WWOX" EXACT PRO-short-label [PRO:DNx]
synonym: "SDR41C1" RELATED Gene-based []
synonym: "fragile site FRA16D oxidoreductase" EXACT []
xref: PIRSF:PIRSF038706
is_a: PR:000000001 ! protein

[Term]
id: PR:000001037
name: WW domain-containing oxidoreductase isoform 1
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "FOR2" RELATED []
synonym: "Wox1" EXACT []
synonym: "FOR II" RELATED []
synonym: "WWOXv1" RELATED []
synonym: "WWOX v8" RELATED []
synonym: "WWOX/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001036 ! WW domain-containing oxidoreductase

[Term]
id: PR:000001054
name: WW domain-containing oxidoreductase isoform 3
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-3 or a 1:1 ortholog thereof. This form lacks the C-terminal short chain dehydrogenase domain." [PRO:CNA]
comment: Category=sequence.
synonym: "FOR3" EXACT []
synonym: "wox3" EXACT []
synonym: "FOR III" EXACT []
synonym: "WWOX/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001036 ! WW domain-containing oxidoreductase

[Term]
id: PR:000001055
name: WW domain-containing oxidoreductase isoform 4
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-4 or a 1:1 ortholog thereof. This is form is truncated within the first WW domain, and is about 37 residues long." [PRO:CNA]
comment: Category=sequence.
synonym: "FOR IV" EXACT []
synonym: "WWOX/iso:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001036 ! WW domain-containing oxidoreductase

[Term]
id: PR:000001056
name: WW domain-containing oxidoreductase isoform 5
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-5 or a 1:1 ortholog thereof. This form lacks the short chain dehydrogenase domain but includes the rest of the C-terminal sequence." [PMID:11719429]
comment: Category=sequence.
synonym: "WWOXv4" RELATED []
synonym: "WWOX/iso:5" EXACT PRO-short-label [PRO:DNx]
synonym: "WWOXdelta6-8" EXACT []
is_a: PR:000001036 ! WW domain-containing oxidoreductase

[Term]
id: PR:Q5F389
name: WW domain-containing oxidoreductase (chicken)
def: "A WW domain-containing oxidoreductase that is encoded in the genome of chicken." [OMA:Q5F389, PRO:DNx]
comment: Category=organism-gene.
synonym: "WWOX" RELATED Gene-based [UniProtKB:Q5F389]
synonym: "chick-WWOX" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_28b1" RELATED Gene-based [UniProtKB:Q5F389]
xref: UniProtKB:Q5F389
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001036 ! WW domain-containing oxidoreductase
relationship: has_gene_template CGNC:50085 ! WWOX (chicken)

[Term]
id: PR:000001053
name: WW domain-containing oxidoreductase isoform 2
def: "A WW domain-containing oxidoreductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NZC7-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "FOR1" RELATED []
synonym: "WOX2" RELATED []
synonym: "FOR I)" RELATED []
synonym: "WWOXv2" RELATED []
synonym: "WWOX/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001036 ! WW domain-containing oxidoreductase