[Term]
id: PR:O14745-2
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform h2 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14745-2." [PRO:DNx, UniProtKB:O14745]
comment: Category=organism-sequence.
synonym: "hSLC9A3R1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14745-2
is_a: PR:O14745 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9JJ19-1
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (rat)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "rSLC9A3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9JJ19-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001042 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1

[Term]
id: PR:O14745
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O14745]
comment: Category=organism-gene.
synonym: "NHERF" RELATED Gene-based [UniProtKB:O14745]
synonym: "NHERF1" RELATED Gene-based [UniProtKB:O14745]
synonym: "SLC9A3R1" RELATED Gene-based [UniProtKB:O14745]
synonym: "hSLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP50 (human)" EXACT [UniProtKB:O14745]
synonym: "NHERF-1 (human)" EXACT [UniProtKB:O14745]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger (human)" EXACT [UniProtKB:O14745]
synonym: "sodium-hydrogen exchanger regulatory factor 1 (human)" EXACT [UniProtKB:O14745]
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50 (human)" EXACT [UniProtKB:O14745]
synonym: "solute carrier family 9 isoform A3 regulatory factor 1 (human)" EXACT [UniProtKB:O14745]
xref: UniProtKB:O14745
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
relationship: has_gene_template HGNC:11075 ! SLC9A3R1 (human)

[Term]
id: PR:Q9JJ19
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (rat)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of rat." [OMA:Q9JJ19, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nherf" RELATED Gene-based [UniProtKB:Q9JJ19]
synonym: "Nherf1" RELATED Gene-based [UniProtKB:Q9JJ19]
synonym: "Slc9a3r1" RELATED Gene-based [UniProtKB:Q9JJ19]
synonym: "rSLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP50 (rat)" EXACT [UniProtKB:Q9JJ19]
synonym: "NHERF-1 (rat)" EXACT [UniProtKB:Q9JJ19]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger (rat)" EXACT [UniProtKB:Q9JJ19]
synonym: "sodium-hydrogen exchanger regulatory factor 1 (rat)" EXACT [UniProtKB:Q9JJ19]
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50 (rat)" EXACT [UniProtKB:Q9JJ19]
synonym: "solute carrier family 9 isoform A3 regulatory factor 1 (rat)" EXACT [UniProtKB:Q9JJ19]
xref: UniProtKB:Q9JJ19
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
relationship: has_gene_template RGD:708538 ! Slc9a3r1 (rat)

[Term]
id: PR:P70441
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (mouse)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of mouse." [OMA:P70441, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nherf" RELATED Gene-based [UniProtKB:P70441]
synonym: "Nherf1" RELATED Gene-based [UniProtKB:P70441]
synonym: "Slc9a3r1" RELATED Gene-based [UniProtKB:P70441]
synonym: "mSLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP50 (mouse)" EXACT [UniProtKB:P70441]
synonym: "NHERF-1 (mouse)" EXACT [UniProtKB:P70441]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger (mouse)" EXACT [UniProtKB:P70441]
synonym: "sodium-hydrogen exchanger regulatory factor 1 (mouse)" EXACT [UniProtKB:P70441]
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50 (mouse)" EXACT [UniProtKB:P70441]
synonym: "solute carrier family 9 isoform A3 regulatory factor 1 (mouse)" EXACT [UniProtKB:P70441]
xref: UniProtKB:P70441
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
relationship: has_gene_template MGI:1349482 ! Slc9a3r1 (mouse)

[Term]
id: PR:000026596
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1, initiator methionine removed form
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SLC9A3R1/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001042 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000018331
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1, initiator methionine removed form
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SLC9A3R1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:O14745-1
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (human)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSLC9A3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14745-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001042 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1

[Term]
id: PR:000001058
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70441-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SLC9A3R1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1

[Term]
id: PR:000046189
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 phosphorylated 1 (mouse)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-77 of the amino acid sequence represented by UniProtKB:P70441-1. Example: UniProtKB:P70441-1, Ser-77, MOD:00046." [PMID:17975671, iPTMnet:P70441]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17975671). Status=unreviewed.
synonym: "mSLC9A3R1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70441-1, Ser-77, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P70441 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P70441-2
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 (mouse)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSLC9A3R1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70441-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001058 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 2

[Term]
id: PR:Q5ZM14
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (chicken)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is encoded in the genome of chicken." [PRO:CNA]
comment: Category=organism-gene.
synonym: "NHERF" RELATED Gene-based [UniProtKB:Q5ZM14]
synonym: "NHERF1" RELATED Gene-based [UniProtKB:Q5ZM14]
synonym: "SLC9A3R1" RELATED Gene-based [UniProtKB:Q5ZM14]
synonym: "RCJMB04_3g21" RELATED Gene-based [UniProtKB:Q5ZM14]
synonym: "chick-SLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP50 (chicken)" EXACT [UniProtKB:Q5ZM14]
synonym: "NHERF-1 (chicken)" EXACT [UniProtKB:Q5ZM14]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger (chicken)" EXACT [UniProtKB:Q5ZM14]
synonym: "sodium-hydrogen exchanger regulatory factor 1 (chicken)" EXACT [UniProtKB:Q5ZM14]
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50 (chicken)" EXACT [UniProtKB:Q5ZM14]
synonym: "solute carrier family 9 isoform A3 regulatory factor 1 (chicken)" EXACT [UniProtKB:Q5ZM14]
xref: UniProtKB:Q5ZM14
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1
relationship: has_gene_template NCBIGene:422108 ! SLC9A3R1 (chicken)

[Term]
id: PR:P70441-1
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 (mouse)
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSLC9A3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70441-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001042 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1

[Term]
id: PR:000001042
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform 1
def: "A Na(+)/H(+) exchange regulatory cofactor NHE-RF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14745-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "SLC9A3R1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001041 ! Na(+)/H(+) exchange regulatory cofactor NHE-RF1

[Term]
id: PR:000001041
name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
def: "A Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain that is a translation product of the human SLC9A3R1 gene or a 1:1 ortholog thereof. It contains two copies of the PDZ domain at the N terminus and an EBP50 domain at the C-terminus. The latter allows interaction with FERM domains, resulting in the activation of ERM proteins (PR:000001030), with subsequent cytoskeletal modulation and cellular growth control." [PRO:CNA]
comment: Category=gene.
synonym: "EBP50" EXACT []
synonym: "NHERF" RELATED Gene-based []
synonym: "NHERF1" RELATED Gene-based []
synonym: "NHERF-1" EXACT []
synonym: "SLC9A3R1" EXACT PRO-short-label [PRO:DNx]
synonym: "regulatory cofactor of Na(+)/H(+) exchanger" EXACT []
synonym: "sodium-hydrogen exchanger regulatory factor 1" EXACT []
synonym: "ezrin-radixin-moesin-binding phosphoprotein 50" EXACT []
synonym: "solute carrier family 9 isoform A3 regulatory factor 1" EXACT []
is_a: PR:000001043 ! Na(+)/H(+) exchange regulatory cofactor with ERM-binding domain