[Term]
id: PR:P25116
name: proteinase-activated receptor 1 (human)
def: "A proteinase-activated receptor 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25116]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "TR" RELATED Gene-based [UniProtKB:P25116]
synonym: "F2R" RELATED Gene-based [UniProtKB:P25116]
synonym: "CF2R" RELATED Gene-based [UniProtKB:P25116]
synonym: "PAR1" RELATED Gene-based [UniProtKB:P25116]
synonym: "hF2R" EXACT PRO-short-label [PRO:DNx]
synonym: "PAR-1 (human)" EXACT [UniProtKB:P25116]
synonym: "thrombin receptor (human)" EXACT [UniProtKB:P25116]
synonym: "coagulation factor II receptor (human)" EXACT [UniProtKB:P25116]
xref: DTO:02100737
xref: UniProtKB:P25116
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001661 ! proteinase-activated receptor 1
relationship: has_gene_template HGNC:3537 ! F2R (human)

[Term]
id: PR:000001661
name: proteinase-activated receptor 1
def: "A proteinase-activated receptor that is a translation product of the human F2R gene or a 1:1 ortholog thereof. It is activated by thrombin, which cleaves the mature peptide, exposing a new amino end. The new N-terminal residues act as a tethered ligand that induces activity." [PMID:1672265, PRO:WCB]
comment: Category=gene.
synonym: "TR" RELATED Gene-based []
synonym: "F2R" EXACT PRO-short-label [PRO:DNx]
synonym: "CF2R" RELATED Gene-based []
synonym: "PAR1" RELATED Gene-based []
synonym: "PAR-1" EXACT []
synonym: "thrombin receptor" EXACT []
synonym: "coagulation factor II receptor" EXACT []
xref: IUPHARobj:347
is_a: PR:000001550 ! proteinase-activated receptor