[Term]
id: PR:Q99JY1
name: Toll/interleukin-1 receptor domain-containing adapter protein (mouse)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse." [OMA:Q99JY1, PRO:CNA]
comment: Category=organism-gene.
synonym: "Mal" RELATED Gene-based [UniProtKB:Q99JY1]
synonym: "Tirap" RELATED Gene-based [UniProtKB:Q99JY1]
synonym: "mTIRAP" EXACT PRO-short-label [PRO:DNx]
synonym: "adaptor protein Wyatt (mouse)" EXACT [UniProtKB:Q99JY1]
synonym: "MyD88 adapter-like protein (mouse)" EXACT [UniProtKB:Q99JY1]
synonym: "TIR domain-containing adapter protein (mouse)" EXACT [UniProtKB:Q99JY1]
xref: UniProtKB:Q99JY1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein
relationship: has_gene_template MGI:2152213 ! Tirap (mouse)

[Term]
id: PR:000001751
name: Toll/interleukin-1 receptor domain-containing adapter protein
def: "A protein that is a translation product of the human TIRAP gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "MAL" RELATED Gene-based []
synonym: "TIRAP" EXACT PRO-short-label [PRO:DNx]
synonym: "adaptor protein Wyatt" EXACT []
synonym: "MyD88 adapter-like protein" EXACT []
synonym: "TIR domain-containing adapter protein" EXACT []
xref: PIRSF:PIRSF037750
is_a: PR:000000001 ! protein

[Term]
id: PR:P58753-3
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform h3 (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-3." [PRO:DNx, UniProtKB:P58753]
comment: Category=organism-sequence.
synonym: "hTIRAP/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P58753-3
is_a: PR:P58753 ! Toll/interleukin-1 receptor domain-containing adapter protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P58753
name: Toll/interleukin-1 receptor domain-containing adapter protein (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "MAL" RELATED Gene-based [UniProtKB:P58753]
synonym: "TIRAP" RELATED Gene-based [UniProtKB:P58753]
synonym: "hTIRAP" EXACT PRO-short-label [PRO:DNx]
synonym: "MyD88-2 (human)" EXACT [UniProtKB:P58753]
synonym: "adaptor protein Wyatt (human)" EXACT [UniProtKB:P58753]
synonym: "MyD88 adapter-like protein (human)" EXACT [UniProtKB:P58753]
synonym: "TIR domain-containing adapter protein (human)" EXACT [UniProtKB:P58753]
xref: Reactome:R-HSA-166141 "PR:P58753 located_in GO:0005829"
xref: UniProtKB:P58753
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein
relationship: has_gene_template HGNC:17192 ! TIRAP (human)

[Term]
id: PR:000027216
name: Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 1 (mouse)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein (mouse) that has been phosphorylated on Tyr residues by the BTK in mouse." [PRO:CNA]
comment: Category=organism-modification.
synonym: "mTIRAP/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mouse mal phosphorylated" EXACT []
synonym: "mouse tirap phosphorylated" EXACT []
is_a: PR:Q99JY1 ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000027214
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PMID:18070880, PRO:CNA]
comment: Category=organism-modification. Requested by=TLR.
synonym: "hTIRAP/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027213 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000027215
name: Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated form
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "TIRAP/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "mal phosphorylated" EXACT []
synonym: "tirap phosphorylated" EXACT []
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein

[Term]
id: PR:P58753-2
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform 2 (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-2." [PRO:CNA, UniProtKB:P58753]
comment: Category=organism-sequence.
synonym: "hTIRAP/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P58753-2
is_a: PR:P58753 ! Toll/interleukin-1 receptor domain-containing adapter protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027213
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1
def: "A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that has been post-translationally modified to include phosphorylated Tyr residues within the TIR domain as a result of tyrosine kinase activation (like Bruton tyrosine kinase). Example: UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PRO:CNA]
comment: Category=modification.
synonym: "TIRAP/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027185 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P58753-1
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTIRAP/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P58753-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027185 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1

[Term]
id: PR:Q4U127
name: Toll-interleukin 1 receptor domain-containing adaptor protein (chicken)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of chicken." [OMA:Q4U127, PRO:CNA]
comment: Category=organism-gene.
synonym: "chick-TIRAP" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q4U127
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein
relationship: has_gene_template CGNC:730 ! TIRAP (chicken)

[Term]
id: PR:Q4PT31
name: disease resistance protein (TIR-NBS class) (Arabidopsis thaliana)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of Arabidopsis thaliana." [PANTHER:PTHR22662:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "At-TIRAP" EXACT PRO-short-label [PRO:DNx]
synonym: "disease resistance protein (Arabidopsis thaliana)" BROAD [UniProtKB:Q4PT31]
xref: UniProtKB:Q4PT31
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein
relationship: has_gene_template Araport:AT1G17615 ! At1g17615 (Arabidopsis thaliana)

[Term]
id: PR:000049460
name: Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 2 (human)
def: "A Toll/interleukin-1 receptor domain-containing adapter protein (human) that has been post-translationally modified to include phosphotyrosine at positions 86, 106, 159 and 187 of the amino acid sequence represented by UniProtKB:P58753. UniProtKB:P58753, Tyr-86/Tyr-106/Tyr-159/Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-2201321]
comment: Category=organism-modification.
synonym: "hTIRAP/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P58753, Tyr-86/Tyr-106/Tyr-159/Tyr-187, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2201321 "PR:000049460 located_in GO:0005886"
is_a: PR:P58753 ! Toll/interleukin-1 receptor domain-containing adapter protein (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027185
name: Toll/interleukin-1 receptor domain-containing adapter protein isoform 1
def: "A Toll/interleukin-1 receptor domain-containing adapter protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "TIRAP/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein