[Term]
id: PR:000001752
name: NF-kappa-B essential modulator
def: "A protein that is a translation product of the human IKBKG gene or a 1:1 ortholog thereof. In response to a large variety of stimuli, among them pro-inflammatory cytokines, growth factors and microbial pathogens, signals emanating from cell surface receptors converge at the IkappaB kinase (IKK) complex. This complex is composed of four subunits, IKKalpha, IKKbeta, ELK, and NEMO. IKKbeta and NEMO subunits are known to be essential for activating NF-kappaB. Activation of NF-kappaB dimers is the result of IKK-mediated, phosphorylation-induced degradation of the IkappaB inhibitor, which enables the NF-kappaB dimers to enter the nucleus and activate specific target gene expression." [PIRSF:PIRSF038160]
comment: Category=gene.
synonym: "FIP3" RELATED Gene-based []
synonym: "IKKG" EXACT []
synonym: "NEMO" RELATED Gene-based []
synonym: "FIP-3" EXACT []
synonym: "IKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKAP1" EXACT []
synonym: "IKK-gamma" EXACT []
synonym: "IkB kinase subunit gamma" EXACT []
synonym: "NF-kappa-B essential modifier" EXACT []
synonym: "I-kappa-B kinase subunit gamma" EXACT []
synonym: "IkB kinase-associated protein 1" EXACT []
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma" EXACT []
xref: PIRSF:PIRSF038160
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9Y6K9
name: NF-kappa-B essential modulator (human)
def: "An NF-kappa-B essential modulator that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "FIP3" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "NEMO" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "IKBKG" RELATED Gene-based [UniProtKB:Q9Y6K9]
synonym: "hIKBKG" EXACT PRO-short-label [PRO:DNx]
synonym: "IKKG (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "FIP-3 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IKKAP1 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IKK-gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IkB kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "NF-kappa-B essential modifier (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "I-kappa-B kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "IkB kinase-associated protein 1 (human)" EXACT [UniProtKB:Q9Y6K9]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit gamma (human)" EXACT [UniProtKB:Q9Y6K9]
xref: Reactome:R-HSA-168108 "PR:Q9Y6K9 located_in GO:0005829"
xref: Reactome:R-HSA-1168576 "PR:Q9Y6K9 located_in GO:0005886"
xref: Reactome:R-HSA-4755413 "PR:Q9Y6K9 located_in GO:0005654"
xref: DTO:03100364
xref: UniProtKB:Q9Y6K9
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001752 ! NF-kappa-B essential modulator
relationship: has_gene_template HGNC:5961 ! IKBKG (human)

[Term]
id: PR:Q9Y6K9-3
name: NF-kappa-B essential modulator isoform h3 (human)
def: "An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-3." [PRO:DNx, UniProtKB:Q9Y6K9]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-3
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y6K9-2
name: NF-kappa-B essential modulator isoform h2 (human)
def: "An NF-kappa-B essential modulator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y6K9-2." [PRO:DNx, UniProtKB:Q9Y6K9]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-2
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y6K9-1
name: NF-kappa-B essential modulator isoform 1 (human)
def: "An NF-kappa-B essential modulator isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hIKBKG/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y6K9-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001763 ! NF-kappa-B essential modulator isoform 1

[Term]
id: PR:000047980
name: NF-kappa-B essential modulator ubiquitinated 1 (human)
def: "An NF-kappa-B essential modulator (human) that has been ubiquitinated on the residue at the position equivalent to Lys-285 of the amino acid sequence represented by UniProtKB:Q9Y6K9. UniProtKB:Q9Y6K9, Lys-285, MOD:01148." [PRO:DNx, Reactome:R-HSA-741397]
comment: Category=organism-modification.
synonym: "hIKBKG/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9, Lys-285, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-741397 "PR:000047980 located_in GO:0005829"
is_a: PR:Q9Y6K9 ! NF-kappa-B essential modulator (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036612
name: NF-kappa-B essential modulator isoform 1 phosphorylated 1 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 1 in human. UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046." [PMID:12657630, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-31/Ser-43/Ser-376, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001766 ! NF-kappa-B essential modulator isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036613
name: NF-kappa-B essential modulator isoform 1 phosphorylated 2 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 2 in human. UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046." [PMID:17977820, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-68, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001767 ! NF-kappa-B essential modulator isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000036614
name: NF-kappa-B essential modulator isoform 1 phosphorylated 3 (human)
def: "An NF-kappa-B essential modulator isoform 1 phosphorylated 3 in human. UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046." [PMID:16497931, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIKBKG/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y6K9-1, Ser-85, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001768 ! NF-kappa-B essential modulator isoform 1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine