[Term]
id: PR:P09619-2
name: platelet-derived growth factor receptor beta isoform h2 (human)
def: "A platelet-derived growth factor receptor beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09619-2." [PRO:DNx, UniProtKB:P09619]
comment: Category=organism-sequence.
synonym: "hPDGFRB/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P09619-2
is_a: PR:P09619 ! platelet-derived growth factor receptor beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P09619-1
name: platelet-derived growth factor receptor beta isoform 1 (human)
def: "A beta-type platelet-derived growth factor receptor isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hPDGFRB/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P09619-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002137 ! beta-type platelet-derived growth factor receptor isoform 2

[Term]
id: PR:000049848
name: platelet-derived growth factor receptor beta, signal peptide removed unphosphorylated 2 (human)
def: "A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and lacks a phosphotyrosine at positions 857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291." [PMID:1653029, PMID:9642269, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:9642269). Evidence=(ECO:0000006, based on PMID:1653029).
synonym: "hPDGFRB/SigPep-/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09619-1, 33-1106, Tyr-857, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P09619 ! platelet-derived growth factor receptor beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000048725
name: platelet-derived growth factor receptor beta, signal peptide removed form (human)
def: "A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed. UniProtKB:P09619, 33-1106." [PRO:DNx, Reactome:R-HSA-186767]
comment: Category=organism-modification.
synonym: "PRO_0000016757" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPDGFRB/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09619, 33-1106" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-186767 "PR:000048725 located_in GO:0005886"
intersection_of: PR:P09619 ! platelet-derived growth factor receptor beta (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P09619
name: platelet-derived growth factor receptor beta (human)
def: "A beta-type platelet-derived growth factor receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P09619]
comment: Category=organism-gene.
synonym: "PDGFR" RELATED Gene-based [UniProtKB:P09619]
synonym: "PDGFR1" RELATED Gene-based [UniProtKB:P09619]
synonym: "PDGFRB" RELATED Gene-based [UniProtKB:P09619]
synonym: "hPDGFRB" EXACT PRO-short-label [PRO:DNx]
synonym: "CD140b (human)" EXACT [UniProtKB:P09619]
synonym: "PDGFR-1 (human)" EXACT [UniProtKB:P09619]
synonym: "PDGFR-beta (human)" EXACT [UniProtKB:P09619]
synonym: "PDGF-R-beta (human)" EXACT [UniProtKB:P09619]
synonym: "CD140 antigen-like family member B (human)" EXACT [UniProtKB:P09619]
synonym: "platelet-derived growth factor receptor 1 (human)" EXACT [UniProtKB:P09619]
synonym: "beta platelet-derived growth factor receptor (human)" EXACT [UniProtKB:P09619]
synonym: "beta-type platelet-derived growth factor receptor (human)" EXACT [UniProtKB:P09619]
xref: DTO:03100404
xref: UniProtKB:P09619
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002035 ! beta-type platelet-derived growth factor receptor
relationship: has_gene_template HGNC:8804 ! PDGFRB (human)

[Term]
id: PR:000048726
name: platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 1 (human)
def: "A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 579, 581, 716, 740, 751, 763, 771, 775, 778, 857, 1009 and 1021 of the amino acid sequence represented by UniProtKB:P09619. UniProtKB:P09619, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048." [PRO:DNx, Reactome:R-HSA-186803]
comment: Category=organism-modification.
synonym: "hPDGFRB/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016757, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P09619, 33-1106, Tyr-579/Tyr-581/Tyr-716/Tyr-740/Tyr-751/Tyr-763/Tyr-771/Tyr-775/Tyr-778/Tyr-857/Tyr-1009/Tyr-1021, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-186803 "PR:000048726 located_in GO:0005886"
is_a: PR:P09619 ! platelet-derived growth factor receptor beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049847
name: platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 3 (human)
def: "A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 857 and a phosphoserine at position 1104 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046." [PMID:15271984, PMID:15994317, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15994317). Evidence=(ECO:0000006, based on PMID:15271984). Kinase=("PDGFRB"; PR:P09619; Tyr-857). Kinase=("GRK2"; PR:000003791; Ser-1104).
synonym: "hPDGFRB/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048|Ser-1104, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P09619 ! platelet-derived growth factor receptor beta (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049846
name: platelet-derived growth factor receptor beta, signal peptide removed phosphorylated 2 (human)
def: "A platelet-derived growth factor receptor beta (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 857 of the amino acid sequence represented by UniProtKB:P09619-1. Example: UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048." [PMID:1653029, PMID:9642269, PRO:KER]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:9642269). Evidence=(ECO:0000006, based on PMID:1653029). Kinase=("PDGFRB"; PR:P09619; Tyr-857).
synonym: "hPDGFRB/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P09619-1, 33-1106, Tyr-857, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P09619 ! platelet-derived growth factor receptor beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000002035
name: beta-type platelet-derived growth factor receptor
def: "A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRB gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "Pdgfr" RELATED []
synonym: "CD140b" EXACT []
synonym: "PDGFR1" RELATED Gene-based []
synonym: "PDGFRB" EXACT PRO-short-label [PRO:DNx]
synonym: "PDGFR-1" EXACT []
synonym: "PDGFR-beta" EXACT []
synonym: "PDGF-R-beta" EXACT []
synonym: "CD140 antigen-like family member B" EXACT []
synonym: "platelet-derived growth factor receptor 1" EXACT []
synonym: "beta platelet-derived growth factor receptor" EXACT []
xref: IUPHARobj:1804
xref: PIRSF:PIRSF500948
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase