[Term]
id: PR:000002041
name: integrin beta-2
def: "An integrin beta that is a translation product of the human ITGB2 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "CD18" RELATED Gene-based []
synonym: "MFI7" RELATED Gene-based []
synonym: "ITGB2" EXACT PRO-short-label [PRO:DNx]
synonym: "complement receptor C3 subunit beta" EXACT []
synonym: "cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta" EXACT []
xref: IUPHARobj:2456
is_a: PR:000001861 ! integrin beta

[Term]
id: PR:000018708
name: integrin beta-2, signal peptide removed form
def: "An integrin beta-2 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "ITGB2/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000002041 ! integrin beta-2
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P05107
name: integrin beta-2 (human)
def: "An integrin beta-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P05107]
comment: Category=organism-gene.
synonym: "CD18" RELATED Gene-based [UniProtKB:P05107]
synonym: "MFI7" RELATED Gene-based [UniProtKB:P05107]
synonym: "ITGB2" RELATED Gene-based [UniProtKB:P05107]
synonym: "hITGB2" EXACT PRO-short-label [PRO:DNx]
synonym: "complement receptor C3 subunit beta (human)" EXACT [UniProtKB:P05107]
synonym: "cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta (human)" EXACT [UniProtKB:P05107]
xref: UniProtKB:P05107
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002041 ! integrin beta-2
relationship: has_gene_template HGNC:6155 ! ITGB2 (human)

[Term]
id: PR:000045640
name: integrin beta-2 phosphorylated 1 (human)
def: "An integrin beta-2 (human) that has been phosphorylated at Tyr-735. UniProtKB:P05107, Tyr-735, MOD:00048." [PMID:22990843, iPTMnet:P05107]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22990843). Status=unreviewed.
synonym: "hITGB2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05107, Tyr-735, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P05107 ! integrin beta-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027392
name: integrin beta-2, signal peptide removed form (human)
def: "An integrin beta-2, signal peptide removed form in human. UniProtKB:P05107, 23-769." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000016341" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hITGB2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P05107, 23-769" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198010 "PR:000027392 located_in GO:0005886"
xref: Reactome:R-HSA-6803284 "PR:000027392 located_in GO:0035579"
xref: Reactome:R-HSA-6803310 "PR:000027392 located_in GO:0101003"
xref: Reactome:R-HSA-6803342 "PR:000027392 located_in GO:0070821"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018708 ! integrin beta-2, signal peptide removed form

[Term]
id: PR:P11835
name: integrin beta-2 (mouse)
def: "An integrin beta-2 that is encoded in the genome of mouse." [OMA:P11835, PRO:DNx]
comment: Category=organism-gene.
synonym: "Itgb2" RELATED Gene-based [UniProtKB:P11835]
synonym: "mITGB2" EXACT PRO-short-label [PRO:DNx]
synonym: "CD18 (mouse)" EXACT [UniProtKB:P11835]
synonym: "complement receptor C3 subunit beta (mouse)" EXACT [UniProtKB:P11835]
synonym: "cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta (mouse)" EXACT [UniProtKB:P11835]
xref: UniProtKB:P11835
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002041 ! integrin beta-2
relationship: has_gene_template MGI:96611 ! Itgb2 (mouse)