[Term]
id: PR:000002089
name: signal transducer and activator of transcription 3
def: "A signal transducer and transcription activator STAT that is a translation product of the human STAT3 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "APRF" RELATED Gene-based []
synonym: "STAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "acute-phase response factor" EXACT []
is_a: PR:000001933 ! signal transducer and transcription activator STAT

[Term]
id: PR:000027924
name: signal transducer and activator of transcription 3 isoform 1 acetylated 1 (human)
def: "A signal transducer and activator of transcription 3 isoform 1 acetylated 1 in human. UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472; Lys-685).
synonym: "STAT3-AcLys685" EXACT []
synonym: "hSTAT3/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40763-1, Lys-685, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027923 ! signal transducer and activator of transcription 3 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P40763-3
name: signal transducer and activator of transcription 3 isoform h3 (human)
def: "A signal transducer and activator of transcription 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-3." [PRO:DNx, UniProtKB:P40763]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40763-3
is_a: PR:P40763 ! signal transducer and activator of transcription 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40763-1
name: signal transducer and activator of transcription 3 isoform 1 (human)
def: "A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of human." [KAT:P40763]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "STAT3 isoform 1 (human)" EXACT []
xref: UniProtKB:P40763-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027921 ! signal transducer and activator of transcription 3 isoform 1

[Term]
id: PR:P40763-2
name: signal transducer and activator of transcription 3 isoform Del-701 (human)
def: "A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:Del-701" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40763-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039402 ! signal transducer and activator of transcription 3 isoform Del-701

[Term]
id: PR:000045774
name: signal transducer and activator of transcription 3 phosphorylated 1 (human)
def: "A signal transducer and activator of transcription 3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-705 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Tyr-705, MOD:00048." [PMID:22306293, PMID:9083098, iPTMnet:P40763]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22306293, PMID:9083098). Status=unreviewed.
synonym: "hSTAT3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40763-1, Tyr-705, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-914048 "PR:000045774 located_in GO:0005829"
xref: Reactome:R-HSA-1112554 "PR:000045774 located_in GO:0005654"
is_a: PR:P40763 ! signal transducer and activator of transcription 3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40763
name: signal transducer and activator of transcription 3 (human)
def: "A signal transducer and activator of transcription 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P40763]
comment: Category=organism-gene.
synonym: "APRF" RELATED Gene-based [UniProtKB:P40763]
synonym: "STAT3" RELATED Gene-based [UniProtKB:P40763]
synonym: "hSTAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "acute-phase response factor (human)" EXACT [UniProtKB:P40763]
xref: Reactome:R-HSA-539044 "PR:P40763 located_in GO:0005829"
xref: UniProtKB:P40763
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002089 ! signal transducer and activator of transcription 3
relationship: has_gene_template HGNC:11364 ! STAT3 (human)