[Term]
id: PR:P35991
name: tyrosine-protein kinase BTK (mouse)
def: "A tyrosine-protein kinase BTK that is encoded in the genome of mouse." [OMA:P35991, PRO:WCB]
comment: Category=organism-gene.
synonym: "Bpk" RELATED Gene-based [UniProtKB:P35991]
synonym: "Btk" RELATED Gene-based [UniProtKB:P35991]
synonym: "mBTK" EXACT PRO-short-label [PRO:DNx]
synonym: "ATK (mouse)" EXACT [UniProtKB:P35991]
synonym: "kinase EMB (mouse)" EXACT [UniProtKB:P35991]
synonym: "bruton tyrosine kinase (mouse)" EXACT [UniProtKB:P35991]
synonym: "B-cell progenitor kinase (mouse)" EXACT [UniProtKB:P35991]
synonym: "agammaglobulinemia tyrosine kinase (mouse)" EXACT [UniProtKB:P35991]
xref: UniProtKB:P35991
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002110 ! tyrosine-protein kinase BTK
relationship: has_gene_template MGI:88216 ! Btk (mouse)

[Term]
id: PR:Q06187
name: tyrosine-protein kinase BTK (human)
def: "A tyrosine-protein kinase BTK that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06187]
comment: Category=organism-gene.
synonym: "ATK" RELATED Gene-based [UniProtKB:Q06187]
synonym: "BPK" RELATED Gene-based [UniProtKB:Q06187]
synonym: "BTK" RELATED Gene-based [UniProtKB:Q06187]
synonym: "hBTK" EXACT PRO-short-label [PRO:DNx]
synonym: "AGMX1" RELATED Gene-based [UniProtKB:Q06187]
synonym: "bruton tyrosine kinase (human)" EXACT [UniProtKB:Q06187]
synonym: "B-cell progenitor kinase (human)" EXACT [UniProtKB:Q06187]
synonym: "agammaglobulinemia tyrosine kinase (human)" EXACT [UniProtKB:Q06187]
xref: DTO:03100050
xref: UniProtKB:Q06187
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002110 ! tyrosine-protein kinase BTK
relationship: has_gene_template HGNC:1133 ! BTK (human)

[Term]
id: PR:000046518
name: tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 2 (human)
def: "A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 223 and 551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2424454, Reactome:R-HSA-984807]
comment: Category=organism-modification.
synonym: "hBTK/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088065, Tyr-223/Tyr-551, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q06187, 2-659, Tyr-223/Tyr-551, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-984807 "PR:000046518 located_in GO:0005886"
xref: Reactome:R-HSA-2424454 "PR:000046518 located_in GO:0005829"
is_a: PR:000044351 ! tyrosine-protein kinase BTK, initiator methionine removed form (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000002110
name: tyrosine-protein kinase BTK
def: "A TEC-type tyrosine-protein kinase that is a translation product of the human BTK gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "ATK" RELATED Gene-based []
synonym: "BPK" RELATED Gene-based []
synonym: "BTK" EXACT PRO-short-label [PRO:DNx]
synonym: "AGMX1" RELATED Gene-based []
synonym: "kinase EMB" EXACT []
synonym: "bruton tyrosine kinase" EXACT []
synonym: "B-cell progenitor kinase" EXACT []
synonym: "agammaglobulinemia tyrosine kinase" EXACT []
synonym: "agammaglobulinaemia tyrosine kinase" EXACT []
xref: IUPHARobj:1948
xref: PIRSF:PIRSF500765
is_a: PR:000001967 ! TEC-type tyrosine-protein kinase

[Term]
id: PR:P35991-1
name: tyrosine-protein kinase BTK isoform 1 (mouse)
def: "A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mBTK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35991-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002236 ! tyrosine-protein kinase BTK isoform 1

[Term]
id: PR:000026589
name: tyrosine-protein kinase BTK isoform 1, initiator methionine removed form
def: "A tyrosine-protein kinase BTK isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "BTK/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000002236 ! tyrosine-protein kinase BTK isoform 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:Q06187-2
name: tyrosine-protein kinase BTK isoform BTK-C (human)
def: "A tyrosine-protein kinase BTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-2." [PRO:DNx, UniProtKB:Q06187]
comment: Category=organism-sequence.
synonym: "hBTK/iso:BTK-C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06187-2
is_a: PR:Q06187 ! tyrosine-protein kinase BTK (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018724
name: tyrosine-protein kinase BTK, initiator methionine removed form
def: "A tyrosine-protein kinase BTK that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "BTK/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000002110 ! tyrosine-protein kinase BTK
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044351
name: tyrosine-protein kinase BTK, initiator methionine removed form (human)
def: "A tyrosine-protein kinase BTK, initiator methionine removed form in human. Example: UniProtKB:Q06187-1, 2-659." [PRO:CNA, UniProtKB:Q06187]
comment: Category=organism-modification.
synonym: "hBTK/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088065" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q06187-1, 2-659" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197948 "PR:000044351 located_in GO:0005829"
xref: Reactome:R-HSA-8964323 "PR:000044351 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018724 ! tyrosine-protein kinase BTK, initiator methionine removed form

[Term]
id: PR:000046519
name: tyrosine-protein kinase BTK, initiator methionine removed phosphorylated 1 (human)
def: "A tyrosine-protein kinase BTK, initiator methionine removed form (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187. UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685603]
comment: Category=organism-modification.
synonym: "hBTK/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088065, Tyr-551, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q06187, 2-659, Tyr-551, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2685603 "PR:000046519 located_in GO:0005829"
xref: Reactome:R-HSA-9606165 "PR:000046519 located_in GO:0005886"
is_a: PR:000044351 ! tyrosine-protein kinase BTK, initiator methionine removed form (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045882
name: tyrosine-protein kinase BTK phosphorylated 1 (human)
def: "A tyrosine-protein kinase BTK (human) that has been phosphorylated on the residue at the position equivalent to Tyr-551 of the amino acid sequence represented by UniProtKB:Q06187-1. Example: UniProtKB:Q06187-1, Tyr-551, MOD:00048." [PMID:11226282, PMID:7565679, iPTMnet:Q06187]
comment: Category=organism-modification. Requestedby=ImmPort. Evidence=(ECO:0000006, based on PMID:11226282).
synonym: "hBTK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "hBTK (pTyr551)" EXACT [PRO:ADD, GOC:add]
synonym: "UniProtKB:Q06187-1, Tyr-551, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q06187 ! tyrosine-protein kinase BTK (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000037482
name: tyrosine-protein kinase BTK phosphorylated 1 (mouse)
def: "A tyrosine-protein kinase BTK (mouse) that is phosphorylated on two Tyr residues. Site 1 is a Tyr within the Src homology type 1 (SH1) domain and is transphosphorylated by a Src family tyrosine kinase. Site 2 is an autophosphorylation site within the Btk SH3 domain. UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048." [PMID:9326643]
comment: Category=organism-modification. Note: Activation of Btk correlates with an increase in the phosphorylation of two regulatory Btk tyrosine residues.
synonym: "active BTK" RELATED []
synonym: "mBTK/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35991, Tyr-223/Tyr-551, MOD:00048" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:P35991 ! tyrosine-protein kinase BTK (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q06187-1
name: tyrosine-protein kinase BTK isoform BTK-A (human)
def: "A tyrosine-protein kinase BTK isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hBTK/iso:BTK-A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q06187-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002236 ! tyrosine-protein kinase BTK isoform 1

[Term]
id: PR:000002236
name: tyrosine-protein kinase BTK isoform 1
def: "A tyrosine-protein kinase BTK that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06187-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "BTK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002110 ! tyrosine-protein kinase BTK