[Term] id: PR:P35968-3 name: vascular endothelial growth factor receptor 2 isoform h3 (human) def: "A vascular endothelial growth factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35968-3." [PRO:DNx, UniProtKB:P35968] comment: Category=organism-sequence. synonym: "hKDR/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial growth factor receptor 2 isoform VEGFR2-712 (human)" EXACT [UniProtKB:P35968] xref: UniProtKB:P35968-3 is_a: PR:P35968 ! vascular endothelial growth factor receptor 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049805 name: vascular endothelial growth factor receptor 2 isoform 1 unphosphorylated 2 (human) def: "A vascular endothelial growth factor receptor 2 isoform 1 (human) that lacks phosphorylation at positions equivalent to Tyr-1054 and Tyr-1059 of the amino acid sequence represented by UniProtKB:P35968-1. UniProtKB:P35968-1, Tyr-1054/Tyr-1059, PR:000026291." [PMID:25698653, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25698653). synonym: "hKDR/iso:1/UnPhos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P35968-1, Tyr-1054/Tyr-1059, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P35968-1 ! vascular endothelial growth factor receptor 2 isoform 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049804 name: vascular endothelial growth factor receptor 2 isoform 1 phosphorylated 2 (human) def: "A vascular endothelial growth factor receptor 2 isoform 1 (human) that has been autophosphorylated at positions equivalent to Tyr-1054 and Tyr-1059 of the amino acid sequence represented by UniProtKB:P35968-1. UniProtKB:P35968-1, Tyr-1054/Tyr-1059, MOD:00048." [PMID:25698653, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25698653). Kinase=("VGRF2"; PR:P35968; Tyr-1054/Tyr-1059). synonym: "hKDR/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P35968-1, Tyr-1054/Tyr-1059, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P35968-1 ! vascular endothelial growth factor receptor 2 isoform 1 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048097 name: vascular endothelial growth factor receptor 2, signal peptide removed phosphorylated 2 (human) def: "A vascular endothelial growth factor receptor 2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 801, 951, 1054, 1059, 1175 and 1214 of the amino acid sequence represented by UniProtKB:P35968. UniProtKB:P35968, 20-1356, Tyr-801/Tyr-951/Tyr-1054/Tyr-1059/Tyr-1175/Tyr-1214, MOD:00048." [PRO:DNx, Reactome:R-HSA-4420103] comment: Category=organism-modification. synonym: "hKDR/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016771, Tyr-801/Tyr-951/Tyr-1054/Tyr-1059/Tyr-1175/Tyr-1214, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P35968, 20-1356, Tyr-801/Tyr-951/Tyr-1054/Tyr-1059/Tyr-1175/Tyr-1214, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4420103 "PR:000048097 located_in GO:0005886" is_a: PR:P35968 ! vascular endothelial growth factor receptor 2 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000048096 name: vascular endothelial growth factor receptor 2, signal peptide removed form (human) def: "A vascular endothelial growth factor receptor 2 (human) that has had the signal peptide removed. UniProtKB:P35968, 20-1356." [PRO:DNx, Reactome:R-HSA-195382] comment: Category=organism-modification. synonym: "hKDR/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016771" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P35968, 20-1356" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-195382 "PR:000048096 located_in GO:0005886" intersection_of: PR:P35968 ! vascular endothelial growth factor receptor 2 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000002112 name: vascular endothelial growth factor receptor 2 def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "KDR" EXACT PRO-short-label [PRO:DNx] synonym: "FLK1" RELATED Gene-based [] synonym: "CD309" EXACT [] synonym: "FLK-1" EXACT [] synonym: "VEGFR2" RELATED Gene-based [] synonym: "VEGFR-2" EXACT [] synonym: "kinase NYK" EXACT [] synonym: "fetal liver kinase 1" EXACT [] synonym: "kinase insert domain receptor" EXACT [] synonym: "protein-tyrosine kinase receptor flk-1" EXACT [] xref: IUPHARobj:1813 is_a: PR:000001971 ! vascular endothelial growth factor receptor [Term] id: PR:000045766 name: vascular endothelial growth factor receptor 2 isoform 1 phosphorylated 1 (human) def: "A vascular endothelial growth factor receptor 2 isoform 1 (human) that has been phosphorylated at Tyr-1059 of the amino acid sequence represented by UniProtKB:P35968-1. UniProtKB:P35968-1, Tyr-1059, MOD:00048." [PMID:10368301, PRO:CNA, iPTMnet:P35968] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10368301). synonym: "hKDR/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P35968-1, Tyr-1059, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P35968-1 ! vascular endothelial growth factor receptor 2 isoform 1 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P35968-2 name: vascular endothelial growth factor receptor 2 isoform h2 (human) def: "A vascular endothelial growth factor receptor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35968-2." [PRO:DNx, UniProtKB:P35968] comment: Category=organism-sequence. synonym: "hKDR/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial growth factor receptor 2 isoform sVegfr-2 (human)" EXACT [UniProtKB:P35968] xref: UniProtKB:P35968-2 is_a: PR:P35968 ! vascular endothelial growth factor receptor 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P35968-1 name: vascular endothelial growth factor receptor 2 isoform 1 (human) def: "A vascular endothelial growth factor receptor 2 isoform 1 that is encoded in the genome of human." [PRO:DAN] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hKDR/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "vascular endothelial growth factor receptor 2 isoform mbVegfr-2 (human)" EXACT [UniProtKB:P35968] xref: UniProtKB:P35968-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000036933 ! vascular endothelial growth factor receptor 2 isoform 1 [Term] id: PR:P35968 name: vascular endothelial growth factor receptor 2 (human) def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P35968] comment: Category=organism-gene. synonym: "KDR" RELATED Gene-based [UniProtKB:P35968] synonym: "FLK1" RELATED Gene-based [UniProtKB:P35968] synonym: "hKDR" EXACT PRO-short-label [PRO:DNx] synonym: "VEGFR2" RELATED Gene-based [UniProtKB:P35968] synonym: "CD309 (human)" EXACT [UniProtKB:P35968] synonym: "FLK-1 (human)" EXACT [UniProtKB:P35968] synonym: "VEGFR-2 (human)" EXACT [UniProtKB:P35968] synonym: "fetal liver kinase 1 (human)" EXACT [UniProtKB:P35968] synonym: "kinase insert domain receptor (human)" EXACT [UniProtKB:P35968] synonym: "protein-tyrosine kinase receptor flk-1 (human)" EXACT [UniProtKB:P35968] xref: DTO:03100560 xref: UniProtKB:P35968 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2 relationship: has_gene_template HGNC:6307 ! KDR (human)