[Term]
id: PR:000046297
name: RAC-alpha serine/threonine-protein kinase phosphorylated 5 (human)
def: "A RAC-alpha serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphotyrosine at positions 315 and 326 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Tyr-315/Tyr-326, MOD:00048." [PRO:DNx, Reactome:R-HSA-8848757]
comment: Category=organism-modification.
synonym: "hAKT1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31749, Tyr-315/Tyr-326, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8848757 "PR:000046297 located_in GO:0005829"
is_a: PR:P31749 ! RAC-alpha serine/threonine-protein kinase (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046296
name: RAC-alpha serine/threonine-protein kinase phosphorylated 1 (human)
def: "A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308, and phosphoserine at position 473 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047|Ser-473, MOD:00046." [PRO:DNx, Reactome:R-HSA-198356, Reactome:R-HSA-198357, Reactome:R-HSA-199430]
comment: Category=organism-modification.
synonym: "hAKT1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31749, Thr-308, MOD:00047|Ser-473, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198356 "PR:000046296 located_in GO:0005829"
xref: Reactome:R-HSA-198357 "PR:000046296 located_in GO:0005654"
xref: Reactome:R-HSA-199430 "PR:000046296 located_in GO:0005886"
is_a: PR:P31749 ! RAC-alpha serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003102
name: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "AKT1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000002286 ! RAC-alpha serine/threonine-protein kinase isoform 1

[Term]
id: PR:000003103
name: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form that is an active kinase form. Example: UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PID:cd8tcrpathway, PID:pi3kciaktpathway, PID:ptp1bpathway, PID:tcrpathway, PMID:12586360, PRO:JAN]
comment: Category=modification.
synonym: "Akt1 active form" EXACT []
synonym: "AKT1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003102 ! RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P31750-1
name: RAC-alpha serine/threonine-protein kinase isoform 1 (mouse)
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mAKT1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P31750-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002286 ! RAC-alpha serine/threonine-protein kinase isoform 1

[Term]
id: PR:000046295
name: RAC-alpha serine/threonine-protein kinase phosphorylated 4 (human)
def: "A RAC-alpha serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-308 of the amino acid sequence represented by UniProtKB:P31749. UniProtKB:P31749, Thr-308, MOD:00047." [PRO:DNx, Reactome:R-HSA-198634]
comment: Category=organism-modification.
synonym: "hAKT1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31749, Thr-308, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198634 "PR:000046295 located_in GO:0005829"
is_a: PR:P31749 ! RAC-alpha serine/threonine-protein kinase (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P47196
name: RAC-alpha serine/threonine-protein kinase (rat)
def: "A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of rat." [OMA:P47196, PRO:DNx]
comment: Category=organism-gene.
synonym: "Akt1" RELATED Gene-based [UniProtKB:P47196]
synonym: "rAKT1" EXACT PRO-short-label [PRO:DNx]
synonym: "PKB (rat)" EXACT [UniProtKB:P47196]
synonym: "PKB alpha (rat)" EXACT [UniProtKB:P47196]
synonym: "RAC-PK-alpha (rat)" EXACT [UniProtKB:P47196]
synonym: "protein kinase B (rat)" EXACT [UniProtKB:P47196]
synonym: "protein kinase B alpha (rat)" EXACT [UniProtKB:P47196]
xref: UniProtKB:P47196
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002190 ! RAC-alpha serine/threonine-protein kinase
relationship: has_gene_template RGD:2081 ! Akt1 (rat)

[Term]
id: PR:P31749-2
name: RAC-alpha serine/threonine-protein kinase isoform h2 (human)
def: "A RAC-alpha serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-2." [PRO:DNx, UniProtKB:P31749]
comment: Category=organism-sequence.
synonym: "hAKT1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P31749-2
is_a: PR:P31749 ! RAC-alpha serine/threonine-protein kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049940
name: RAC-alpha serine/threonine-protein kinase phosphorylated 3 (mouse)
def: "A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, MOD:00046." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "mAKT1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31750, Ser-473, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049939 ! RAC-alpha serine/threonine-protein kinase phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027472
name: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form that is the actived form (see PR:000003103), which has been further phosphorylated by autocatalysis in trans at two sites that lie in the characteristic AKT substrate motif RxRxx[ST]. Example: UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]
comment: Category=modification.
synonym: "AKT1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "Akt1 autophosphorylated" EXACT []
is_a: PR:000003102 ! RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027473
name: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 (human)
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046." [PMID:16549426, PRO:PD]
comment: Category=organism-modification.
synonym: "hAKT1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31749-1, Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027472 ! RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P31750
name: RAC-alpha serine/threonine-protein kinase (mouse)
def: "A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of mouse." [OMA:P31750, PRO:DNx]
comment: Category=organism-gene.
synonym: "Akt" RELATED Gene-based [UniProtKB:P31750]
synonym: "Rac" RELATED Gene-based [UniProtKB:P31750]
synonym: "Akt1" RELATED Gene-based [UniProtKB:P31750]
synonym: "mAKT1" EXACT PRO-short-label [PRO:DNx]
synonym: "PKB (mouse)" EXACT [UniProtKB:P31750]
synonym: "PKB alpha (mouse)" EXACT [UniProtKB:P31750]
synonym: "AKT1 kinase (mouse)" EXACT [UniProtKB:P31750]
synonym: "RAC-PK-alpha (mouse)" EXACT [UniProtKB:P31750]
synonym: "protein kinase B (mouse)" EXACT [UniProtKB:P31750]
synonym: "proto-oncogene c-Akt (mouse)" EXACT [UniProtKB:P31750]
synonym: "protein kinase B alpha (mouse)" EXACT [UniProtKB:P31750]
synonym: "thymoma viral proto-oncogene (mouse)" EXACT [UniProtKB:P31750]
xref: UniProtKB:P31750
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002190 ! RAC-alpha serine/threonine-protein kinase
relationship: has_gene_template MGI:87986 ! Akt1 (mouse)

[Term]
id: PR:000046294
name: RAC-alpha serine/threonine-protein kinase phosphorylated 3 (human)
def: "A RAC-alpha serine/threonine-protein kinase phosphorylated 3 in human. UniProtKB:P31749, Ser-473, MOD:00046." [PRO:CNA, PRO:DNx, Reactome:R-HSA-377265]
comment: Category=organism-modification.
synonym: "hAKT1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31749, Ser-473, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-377265 "PR:000046294 located_in GO:0005886"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000049939 ! RAC-alpha serine/threonine-protein kinase phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000002190
name: RAC-alpha serine/threonine-protein kinase
def: "An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "Akt" RELATED Gene-based []
synonym: "PKB" BROAD Gene-based [PRO:DNx]
synonym: "RAC" RELATED Gene-based []
synonym: "AKT1" EXACT PRO-short-label [PRO:DNx]
synonym: "PKB alpha" EXACT []
synonym: "AKT1 kinase" EXACT []
synonym: "RAC-PK-alpha" EXACT []
synonym: "protein kinase B" EXACT []
synonym: "proto-oncogene c-Akt" EXACT []
synonym: "protein kinase B alpha" EXACT []
synonym: "thymoma viral proto-oncogene" EXACT []
xref: IUPHARobj:1479
is_a: PR:000029189 ! AKT kinase

[Term]
id: PR:P31749
name: RAC-alpha serine/threonine-protein kinase (human)
def: "A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human." [PRO:WCB, UniProtKB:P31749]
comment: Category=organism-gene.
synonym: "PKB" RELATED Gene-based [UniProtKB:P31749]
synonym: "RAC" RELATED Gene-based [UniProtKB:P31749]
synonym: "AKT1" RELATED Gene-based [UniProtKB:P31749]
synonym: "hAKT1" EXACT PRO-short-label [PRO:DNx]
synonym: "PKB alpha (human)" EXACT [UniProtKB:P31749]
synonym: "RAC-PK-alpha (human)" EXACT [UniProtKB:P31749]
synonym: "protein kinase B (human)" EXACT [UniProtKB:P31749]
synonym: "proto-oncogene c-Akt (human)" EXACT [UniProtKB:P31749]
synonym: "protein kinase B alpha (human)" EXACT [UniProtKB:P31749]
xref: Reactome:R-HSA-58252 "PR:P31749 located_in GO:0005829"
xref: Reactome:R-HSA-199416 "PR:P31749 located_in GO:0005886"
xref: DTO:03100019
xref: UniProtKB:P31749
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002190 ! RAC-alpha serine/threonine-protein kinase
relationship: has_gene_template HGNC:391 ! AKT1 (human)

[Term]
id: PR:000049942
name: RAC-alpha serine/threonine-protein kinase unphosphorylated 3 (mouse)
def: "A RAC-alpha serine/threonine-protein kinase unphosphorylated 3 in mouse. UniProtKB:P31750, Ser-473, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:27994061).
synonym: "mAKT1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P31750, Ser-473, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000049941 ! RAC-alpha serine/threonine-protein kinase unphosphorylated 3

[Term]
id: PR:000002286
name: RAC-alpha serine/threonine-protein kinase isoform 1
def: "A RAC-alpha serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P31749-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "AKT1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002190 ! RAC-alpha serine/threonine-protein kinase

[Term]
id: PR:000049941
name: RAC-alpha serine/threonine-protein kinase unphosphorylated 3
def: "A RAC-alpha serine/threonine-protein kinase that lacks phosphorylation at the position equivalent to Ser-473 of the amino acid sequence represented by UniProtKB:P31749. Example: UniProtKB:P31749, Ser-473, PR:000026291." [PMID:27994061, PRO:LN]
comment: Category=modification.
synonym: "AKT1/UnPhos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002190 ! RAC-alpha serine/threonine-protein kinase

[Term]
id: PR:000028994
name: RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 (human)
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1 in human. UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046." [PMID:8978681, PRO:ALI]
comment: Category=organism-modification. Kinase=("MAPKAPK2"; PR:000010165).
synonym: "hAKT1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Akt1 active form (human)" RELATED []
synonym: "UniProtKB:P31749-1, Thr-308, MOD:00047|Ser-473, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003103 ! RAC-alpha serine/threonine-protein kinase isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049939
name: RAC-alpha serine/threonine-protein kinase phosphorylated 3
def: "A RAC-alpha serine/threonine-protein kinase that has been phosphorylated on the residue at the position equivalent to Ser-473 of the amino acid sequence represented by UniProtKB:P31749. Example: UniProtKB:P31749, Ser-473, MOD:00046." [PMID:27994061, PRO:LN, Reactome:R-HSA-377265]
comment: Category=modification.
synonym: "AKT1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002190 ! RAC-alpha serine/threonine-protein kinase
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P31749-1
name: RAC-alpha serine/threonine-protein kinase isoform 1 (human)
def: "A RAC-alpha serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hAKT1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P31749-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002286 ! RAC-alpha serine/threonine-protein kinase isoform 1