[Term]
id: PR:Q6IWL4
name: TNF receptor-associated factor 6 (zebrafish)
def: "A TNF receptor-associated factor 6 that is encoded in the genome of zebrafish." [OMA:Q6IWL4, PRO:DNx]
comment: Category=organism-gene.
synonym: "traf6" RELATED Gene-based [UniProtKB:Q6IWL4]
synonym: "z-TRAF6" EXACT PRO-short-label [PRO:DNx]
synonym: "si:dkey-56p7.3" RELATED Gene-based [UniProtKB:Q6IWL4]
synonym: "E3 ubiquitin-protein ligase TRAF6 (zebrafish)" EXACT [UniProtKB:Q6IWL4]
synonym: "RING-type E3 ubiquitin transferase TRAF6 (zebrafish)" EXACT [UniProtKB:Q6IWL4]
xref: UniProtKB:Q6IWL4
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000002292 ! TNF receptor-associated factor 6
relationship: has_gene_template ZFIN:ZDB-GENE-030131-5735 ! traf6 (zebrafish)

[Term]
id: PR:000035712
name: TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
def: "A TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 in mouse. UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]
comment: Category=organism-modification.
synonym: "K63-pUb-TRAF6" RELATED []
synonym: "mTRAF6/iso:1/K63polyUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70196-1, Lys-124, PR:000044772" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003139 ! TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:000035713
name: TNF receptor-associated factor 6 K63-polyubiquitinated 1
def: "A TNF receptor-associated factor 6 that is a major product of site-specific Lys-63-linked auto-ubiquitination. Example: UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:CNx, PRO:DAN]
comment: Category=modification. Requested by=TLR.
synonym: "TRAF6/K63polyUbiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002292 ! TNF receptor-associated factor 6
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:000035714
name: TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
def: "A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
comment: Category=organism-modification.
synonym: "K63-pUb-TRAF6" RELATED []
synonym: "hTRAF6/K63polyUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y4K3, Lys-124, PR:000044772" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-936980 "PR:000035714 located_in GO:0005886"
xref: Reactome:R-HSA-450227 "PR:000035714 located_in GO:0010008"
xref: Reactome:R-HSA-2685681 "PR:000035714 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035713 ! TNF receptor-associated factor 6 K63-polyubiquitinated 1
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:Q9Y4K3-1
name: TNF receptor-associated factor 6 isoform 1 (human)
def: "A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hTRAF6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Y4K3-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002381 ! TNF receptor-associated factor 6 isoform 1

[Term]
id: PR:B5DF45
name: TNF receptor-associated factor 6 (rat)
def: "A TNF receptor-associated factor 6 that is encoded in the genome of rat." [OMA:B5DF45, PRO:DNx]
comment: Category=organism-gene.
synonym: "Traf6" RELATED Gene-based [UniProtKB:B5DF45]
synonym: "rTRAF6" EXACT PRO-short-label [PRO:DNx]
synonym: "E3 ubiquitin-protein ligase TRAF6 (rat)" EXACT [UniProtKB:B5DF45]
synonym: "RING-type E3 ubiquitin transferase TRAF6 (rat)" EXACT [UniProtKB:B5DF45]
xref: UniProtKB:B5DF45
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002292 ! TNF receptor-associated factor 6
relationship: has_gene_template RGD:1306853 ! Traf6 (rat)

[Term]
id: PR:P70196-1
name: TNF receptor-associated factor 6 isoform 1 (mouse)
def: "A TNF receptor-associated factor 6 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mTRAF6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70196-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002381 ! TNF receptor-associated factor 6 isoform 1

[Term]
id: PR:P70196-2
name: TNF receptor-associated factor 6 isoform 2 (mouse)
def: "A TNF receptor-associated factor 6 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mTRAF6/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70196-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002382 ! TNF receptor-associated factor 6 isoform 2

[Term]
id: PR:000003139
name: TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
def: "A TNF receptor-associated factor 6 isoform 1 ubiquitinated form that is a major product of site-specific Lys-63-linked auto-ubiquitination. The ubiquitinated Lys residue is located downstream the RING domain. Example: UniProtKB:P70196-1, Lys-124, PR:000044772." [PMID:17135271, PRO:HJD, TLR:AMM]
comment: Category=modification. Merge because of duplication. Requested by=TLR.
synonym: "TRAF6/iso:1/K63polyUbiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003138 ! TNF receptor-associated factor 6 isoform 1 ubiquitinated form
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:000003138
name: TNF receptor-associated factor 6 isoform 1 ubiquitinated form
def: "A TNF receptor-associated factor 6 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "TRAF6/iso:1/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000002381 ! TNF receptor-associated factor 6 isoform 1

[Term]
id: PR:P70196
name: TNF receptor-associated factor 6 (mouse)
def: "A TNF receptor-associated factor 6 that is encoded in the genome of mouse." [OMA:P70196, PRO:CNA]
comment: Category=organism-gene. Requested by=TLR.
synonym: "Traf6" RELATED Gene-based [UniProtKB:P70196]
synonym: "mTRAF6" EXACT PRO-short-label [PRO:DNx]
synonym: "E3 ubiquitin-protein ligase TRAF6 (mouse)" EXACT [UniProtKB:P70196]
synonym: "RING-type E3 ubiquitin transferase TRAF6 (mouse)" EXACT [UniProtKB:P70196]
xref: UniProtKB:P70196
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002292 ! TNF receptor-associated factor 6
relationship: has_gene_template MGI:108072 ! Traf6 (mouse)

[Term]
id: PR:000002381
name: TNF receptor-associated factor 6 isoform 1
def: "A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y4K3-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "TRAF6/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002292 ! TNF receptor-associated factor 6

[Term]
id: PR:Q9Y4K3
name: TNF receptor-associated factor 6 (human)
def: "A TNF receptor-associated factor 6 that is encoded in the genome of human." [PRO:CNx, UniProtKB:Q9Y4K3]
comment: Category=organism-gene.
synonym: "RNF85" RELATED Gene-based [UniProtKB:Q9Y4K3]
synonym: "TRAF6" RELATED Gene-based [UniProtKB:Q9Y4K3]
synonym: "hTRAF6" EXACT PRO-short-label [PRO:DNx]
synonym: "RING finger protein 85 (human)" EXACT [UniProtKB:Q9Y4K3]
synonym: "interleukin-1 signal transducer (human)" EXACT [UniProtKB:Q9Y4K3]
synonym: "E3 ubiquitin-protein ligase TRAF6 (human)" EXACT [UniProtKB:Q9Y4K3]
synonym: "RING-type E3 ubiquitin transferase TRAF6 (human)" EXACT [UniProtKB:Q9Y4K3]
xref: Reactome:R-HSA-166366 "PR:Q9Y4K3 located_in GO:0005829"
xref: Reactome:R-HSA-936955 "PR:Q9Y4K3 located_in GO:0005886"
xref: Reactome:R-HSA-450272 "PR:Q9Y4K3 located_in GO:0010008"
xref: UniProtKB:Q9Y4K3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002292 ! TNF receptor-associated factor 6
relationship: has_gene_template HGNC:12036 ! TRAF6 (human)

[Term]
id: PR:000002382
name: TNF receptor-associated factor 6 isoform 2
def: "A TNF receptor-associated factor 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70196-2 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "TRAF6/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002292 ! TNF receptor-associated factor 6

[Term]
id: PR:000002292
name: TNF receptor-associated factor 6
def: "A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "RNF85" RELATED Gene-based []
synonym: "TRAF6" EXACT PRO-short-label [PRO:DNx]
synonym: "RING finger protein 85" EXACT []
synonym: "interleukin-1 signal transducer" EXACT []
synonym: "E3 ubiquitin-protein ligase TRAF6" EXACT []
synonym: "RING-type E3 ubiquitin transferase TRAF6" EXACT []
is_a: PR:000002191 ! TNF receptor-associated factor