[Term] id: PR:P29594-1 name: caspase-2 isoform 1 (mouse) def: "A caspase-2 isoform 1 that is encoded in the genome of mouse." [PRO:JAN] comment: Category=organism-sequence. synonym: "mCASP2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29594-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002400 ! caspase-2 isoform 1 [Term] id: PR:000002400 name: caspase-2 isoform 1 def: "A caspase-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42575-1 or a 1:1 ortholog thereof. This isoform acts as a positive regulator of apoptosis." [PRO:JAN] comment: Category=sequence. synonym: "CASP2/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform ICH-1L" EXACT [] is_a: PR:000002311 ! caspase-2 [Term] id: PR:000002401 name: caspase-2 isoform 2 def: "A caspase-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42575-2 or a 1:1 ortholog thereof. This isoform acts as a negative regulator of apoptosis." [PRO:JAN] comment: Category=sequence. synonym: "CASP2/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform ICH-1S" EXACT [] is_a: PR:000002311 ! caspase-2 [Term] id: PR:Q9XYF4 name: caspase Dronc (fruit fly) def: "A caspase-2 that is encoded in the genome of fruit fly." [OMA:Q9XYF4, PRO:DNx] comment: Category=organism-gene. synonym: "Nc" RELATED Gene-based [UniProtKB:Q9XYF4] synonym: "Dronc" RELATED Gene-based [UniProtKB:Q9XYF4] synonym: "CG8091" RELATED Gene-based [UniProtKB:Q9XYF4] synonym: "fly-CASP2" EXACT PRO-short-label [PRO:DNx] synonym: "NEDD2-like caspase (fruit fly)" EXACT [UniProtKB:Q9XYF4] xref: UniProtKB:Q9XYF4 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000002311 ! caspase-2 relationship: has_gene_template FlyBase:FBgn0026404 ! Dronc (fruit fly) [Term] id: PR:000002311 name: caspase-2 def: "A caspase-1-like protease that is a translation product of the human CASP2 gene or a 1:1 ortholog thereof. This protein is involved in the activation cascade of caspases responsible for apoptosis execution." [PRO:WCB] comment: Category=gene. synonym: "ICH1" RELATED Gene-based [] synonym: "CASP2" EXACT PRO-short-label [PRO:DNx] synonym: "NEDD2" RELATED Gene-based [] synonym: "CASP-2" EXACT [] synonym: "NEDD-2" EXACT [] synonym: "protease ICH-1" EXACT [] synonym: "neural precursor cell expressed developmentally down-regulated protein 2" EXACT [] xref: IUPHARobj:1618 is_a: PR:000002195 ! caspase-1-like protease [Term] id: PR:P42575-3 name: caspase-2 isoform h3 (human) def: "A caspase-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42575-3." [PRO:DNx, UniProtKB:P42575] comment: Category=organism-sequence. synonym: "hCASP2/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform Casp-2L-Pro (human)" EXACT [UniProtKB:P42575] xref: UniProtKB:P42575-3 is_a: PR:P42575 ! caspase-2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P42575-2 name: caspase-2 isoform 2 (human) def: "A caspase-2 isoform 2 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP2/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform ICH-1S (human)" EXACT [UniProtKB:P42575] xref: UniProtKB:P42575-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002401 ! caspase-2 isoform 2 [Term] id: PR:P42575-1 name: caspase-2 isoform 1 (human) def: "A caspase-2 isoform 1 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP2/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform ICH-1L (human)" EXACT [UniProtKB:P42575] xref: UniProtKB:P42575-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002400 ! caspase-2 isoform 1 [Term] id: PR:000002451 name: caspase-2 subunit p18 def: "A caspase-2 isoform 1 that corresponds to the N-terminal portion after removal of the propeptides. Example: UniProtKB:P42575-1, 170-325." [PMID:8654923, PRO:DAN, PRO:JAN] comment: Category=modification. Note: This proteoform can only arise through processing of isoform 1. synonym: "CASP2/p18" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002400 ! caspase-2 isoform 1 relationship: output_of GO:0016485 ! protein processing relationship: lacks_part SO:0001062 ! propeptide [Term] id: PR:000002453 name: caspase-2 subunit p12 def: "A caspase-2 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides and a short intersubunit linker (in humans, the N-terminal-most 14 amino acids of the p13 form). UniProtKB:P42575-1, 348-452." [PMID:8654923, PRO:DAN, PRO:JAN] comment: Category=modification. Note: This proteoform can only arise through processing of isoform 1. synonym: "CASP2/p12" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002400 ! caspase-2 isoform 1 relationship: output_of GO:0016485 ! protein processing relationship: lacks_part SO:0001062 ! propeptide [Term] id: PR:000002452 name: caspase-2 subunit p13 def: "A caspase-2 isoform 1 that corresponds to the C-terminal portion after removal of the propeptides. UniProtKB:P42575-1, 334-452." [PMID:8654923, PRO:DAN, PRO:JAN] comment: Category=modification. Note: This proteoform can only arise through processing of isoform 1. synonym: "CASP2/p13" EXACT PRO-short-label [PRO:DNx] is_a: PR:000002400 ! caspase-2 isoform 1 relationship: output_of GO:0016485 ! protein processing relationship: lacks_part SO:0001062 ! propeptide [Term] id: PR:000050112 name: caspase-2 subunit p12 (human) def: "A caspase-2 subunit p12 in human. Example: UniProtKB:P42575-1, 348-452." [PRO:DNx, UniProtKB:P42575] comment: Category=organism-modification. synonym: "hCASP2/p12" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000004545" NARROW PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P42575-1, 348-452" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002453 ! caspase-2 subunit p12 [Term] id: PR:000050111 name: caspase-2 subunit p13 (human) def: "A caspase-2 subunit p13 in human. Example: UniProtKB:P42575-1, 334-452." [PRO:DNx, UniProtKB:P42575] comment: Category=organism-modification. synonym: "hCASP2/p13" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000004544" NARROW PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P42575-1, 334-452" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002452 ! caspase-2 subunit p13 [Term] id: PR:000050110 name: caspase-2 subunit p18 (human) def: "A caspase-2 subunit p18 in human. Example: UniProtKB:P42575-1, 170-325." [PRO:DNx, UniProtKB:P42575] comment: Category=organism-modification. synonym: "hCASP2/p18" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000004542" NARROW PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P42575-1, 170-325" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002451 ! caspase-2 subunit p18 [Term] id: PR:000046570 name: caspase-2, initiator methionine removed form (human) def: "A caspase-2 (human) that has had the initiator methionine removed. UniProtKB:P42575, 2-452." [PRO:DNx, Reactome:R-HSA-622412] comment: Category=organism-modification. synonym: "hCASP2/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P42575, 2-452" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-622412 "PR:000046570 located_in GO:0005829" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P42575 ! caspase-2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P55215-2 name: caspase-2 isoform r2 (rat) def: "A caspase-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55215-2." [PRO:DNx, UniProtKB:P55215] comment: Category=organism-sequence. synonym: "rCASP2/iso:r2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform caspase-2S (rat)" EXACT [UniProtKB:P55215] xref: UniProtKB:P55215-2 is_a: PR:P55215 ! caspase-2 (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:P55215-1 name: caspase-2 isoform r1 (rat) def: "A caspase-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55215-1." [PRO:DNx, UniProtKB:P55215] comment: Category=organism-sequence. synonym: "rCASP2/iso:r1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-2 isoform caspase-2L (rat)" EXACT [UniProtKB:P55215] xref: UniProtKB:P55215-1 is_a: PR:P55215 ! caspase-2 (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:P29594 name: caspase-2 (mouse) def: "A caspase-2 that is encoded in the genome of mouse." [OMA:P29594, PRO:DNx] comment: Category=organism-gene. synonym: "Ich1" RELATED Gene-based [UniProtKB:P29594] synonym: "Casp2" RELATED Gene-based [UniProtKB:P29594] synonym: "Nedd2" RELATED Gene-based [UniProtKB:P29594] synonym: "Nedd-2" RELATED Gene-based [UniProtKB:P29594] synonym: "mCASP2" EXACT PRO-short-label [PRO:DNx] synonym: "CASP-2 (mouse)" EXACT [UniProtKB:P29594] synonym: "NEDD-2 (mouse)" EXACT [UniProtKB:P29594] synonym: "protease ICH-1 (mouse)" EXACT [UniProtKB:P29594] synonym: "neural precursor cell expressed developmentally down-regulated protein 2 (mouse)" EXACT [UniProtKB:P29594] xref: UniProtKB:P29594 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002311 ! caspase-2 relationship: has_gene_template MGI:97295 ! Casp2 (mouse) [Term] id: PR:000018760 name: caspase-2, initiator methionine removed form def: "A caspase-2 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "CASP2/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000002311 ! caspase-2 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000018761 name: caspase-2 proteolytic cleavage product def: "A caspase-2 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CASP2/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000002311 ! caspase-2 [Term] id: PR:000045782 name: caspase-2 phosphorylated 1 (human) def: "A caspase-2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-157 of the amino acid sequence represented by UniProtKB:P42575-1. Example: UniProtKB:P42575-1, Ser-157, MOD:00046." [PMID:16193064, iPTMnet:P42575] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16193064). Status=unreviewed. synonym: "hCASP2/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P42575-1, Ser-157, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P42575 ! caspase-2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P55215 name: caspase-2 (rat) def: "A caspase-2 that is encoded in the genome of rat." [OMA:P55215, PANTHER:PTHR10454:SF21, PRO:DNx] comment: Category=organism-gene. synonym: "Ich1" RELATED Gene-based [UniProtKB:P55215] synonym: "Casp2" RELATED Gene-based [UniProtKB:P55215] synonym: "rCASP2" EXACT PRO-short-label [PRO:DNx] synonym: "CASP-2 (rat)" EXACT [UniProtKB:P55215] synonym: "protease ICH-1 (rat)" EXACT [UniProtKB:P55215] xref: UniProtKB:P55215 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002311 ! caspase-2 relationship: has_gene_template RGD:69274 ! Casp2 (rat) [Term] id: PR:P42575 name: caspase-2 (human) def: "A caspase-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P42575] comment: Category=organism-gene. synonym: "ICH1" RELATED Gene-based [UniProtKB:P42575] synonym: "CASP2" RELATED Gene-based [UniProtKB:P42575] synonym: "NEDD2" RELATED Gene-based [UniProtKB:P42575] synonym: "hCASP2" EXACT PRO-short-label [PRO:DNx] synonym: "CASP-2 (human)" EXACT [UniProtKB:P42575] synonym: "NEDD-2 (human)" EXACT [UniProtKB:P42575] synonym: "protease ICH-1 (human)" EXACT [UniProtKB:P42575] synonym: "neural precursor cell expressed developmentally down-regulated protein 2 (human)" EXACT [UniProtKB:P42575] xref: UniProtKB:P42575 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002311 ! caspase-2 relationship: has_gene_template HGNC:1503 ! CASP2 (human)