[Term] id: PR:000002317 name: caspase-8 def: "A caspase-8-like protease that is a translation product of the human CASP8 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "CAP4" EXACT [] synonym: "MACH" EXACT [] synonym: "MCH5" RELATED Gene-based [] synonym: "CASP8" EXACT PRO-short-label [PRO:DNx] synonym: "FLICE" EXACT [] synonym: "CASP-8" EXACT [] synonym: "FADD-like ICE" EXACT [] synonym: "apoptotic protease Mch-5" EXACT [] synonym: "apoptotic cysteine protease" EXACT [] synonym: "ICE-like apoptotic protease 5" EXACT [] synonym: "MORT1-associated ced-3 homolog" EXACT [] synonym: "FADD-homologous ICE/ced-3-like protease" EXACT [] xref: IUPHARobj:1624 xref: PIRSF:PIRSF500656 is_a: PR:000002197 ! caspase-8-like protease [Term] id: PR:000036063 name: caspase-8 isoform 1 cleaved 1 (human) def: "A caspase-8 isoform 1 cleaved 1 in human. UniProtKB:Q14790-1, 217-374." [PMID:9184224, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000004629" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hCASP8/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14790-1, 217-374" EXACT PRO-proteoform-std [PRO:DNx] synonym: "human caspase-8 subunit p18" EXACT [] xref: Reactome:R-HSA-75975 "PR:000036063 located_in GO:0005829" xref: Reactome:R-HSA-351869 "PR:000036063 located_in GO:0005741" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000036062 ! caspase-8 isoform 1 cleaved 1 [Term] id: PR:000036065 name: caspase-8 isoform 1 cleaved 2 (human) def: "A caspase-8 isoform 1 cleaved 2 in human. UniProtKB:Q14790-1, 385-479." [PMID:9184224, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000004631" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hCASP8/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14790-1, 385-479" EXACT PRO-proteoform-std [PRO:DNx] synonym: "human caspase-8 subunit p10" EXACT [] xref: Reactome:R-HSA-76158 "PR:000036065 located_in GO:0005829" xref: Reactome:R-HSA-351828 "PR:000036065 located_in GO:0005741" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000036064 ! caspase-8 isoform 1 cleaved 2 [Term] id: PR:Q14790-1 name: caspase-8 isoform 1 (human) def: "A caspase-8 isoform 1 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Alpha-1 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002412 ! caspase-8 isoform 1 [Term] id: PR:Q14790-2 name: caspase-8 isoform 2 (human) def: "A caspase-8 isoform 2 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Alpha-2 (human)" EXACT [UniProtKB:Q14790] synonym: "caspase-8 isoform MCH5-beta (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002413 ! caspase-8 isoform 2 [Term] id: PR:Q14790-3 name: caspase-8 isoform 3 (human) def: "A caspase-8 isoform 3 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:3" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Alpha-3 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-3 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002414 ! caspase-8 isoform 3 [Term] id: PR:Q14790 name: caspase-8 (human) def: "A caspase-8 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-gene. synonym: "MCH5" RELATED Gene-based [UniProtKB:Q14790] synonym: "CASP8" RELATED Gene-based [UniProtKB:Q14790] synonym: "hCASP8" EXACT PRO-short-label [PRO:DNx] synonym: "CAP4 (human)" EXACT [UniProtKB:Q14790] synonym: "MACH (human)" EXACT [UniProtKB:Q14790] synonym: "FLICE (human)" EXACT [UniProtKB:Q14790] synonym: "CASP-8 (human)" EXACT [UniProtKB:Q14790] synonym: "FADD-like ICE (human)" EXACT [UniProtKB:Q14790] synonym: "apoptotic protease Mch-5 (human)" EXACT [UniProtKB:Q14790] synonym: "apoptotic cysteine protease (human)" EXACT [UniProtKB:Q14790] synonym: "ICE-like apoptotic protease 5 (human)" EXACT [UniProtKB:Q14790] synonym: "MORT1-associated ced-3 homolog (human)" EXACT [UniProtKB:Q14790] synonym: "FADD-homologous ICE/ced-3-like protease (human)" EXACT [UniProtKB:Q14790] xref: Reactome:R-HSA-57031 "PR:Q14790 located_in GO:0005829" xref: UniProtKB:Q14790 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002317 ! caspase-8 relationship: has_gene_template HGNC:1509 ! CASP8 (human) [Term] id: PR:Q14790-6 name: caspase-8 isoform 6 (human) def: "A caspase-8 isoform 6 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:6" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Beta-2 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-6 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002417 ! caspase-8 isoform 6 [Term] id: PR:Q14790-7 name: caspase-8 isoform 7 (human) def: "A caspase-8 isoform 7 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:7" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform 8L (human)" BROAD [UniProtKB:Q14790] synonym: "caspase-8 isoform Beta-3 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-7 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002418 ! caspase-8 isoform 7 [Term] id: PR:Q14790-4 name: caspase-8 isoform 4 (human) def: "A caspase-8 isoform 4 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:4" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Alpha-4 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-4 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002415 ! caspase-8 isoform 4 [Term] id: PR:Q14790-5 name: caspase-8 isoform 5 (human) def: "A caspase-8 isoform 5 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:5" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Beta-1 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-5 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002416 ! caspase-8 isoform 5 [Term] id: PR:Q14790-8 name: caspase-8 isoform 8 (human) def: "A caspase-8 isoform 8 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:8" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform Beta-4 (human)" EXACT [UniProtKB:Q14790] xref: UniProtKB:Q14790-8 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002419 ! caspase-8 isoform 8 [Term] id: PR:Q14790-9 name: caspase-8 isoform 9 (human) def: "A caspase-8 isoform 9 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP8/iso:9" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-8 isoform 8L (human)" BROAD [UniProtKB:Q14790] xref: UniProtKB:Q14790-9 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002420 ! caspase-8 isoform 9 [Term] id: PR:000045931 name: caspase-8 phosphorylated 1 (human) def: "A caspase-8 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-380 of the amino acid sequence represented by UniProtKB:Q14790-1. Example: UniProtKB:Q14790-1, Tyr-380, MOD:00048." [PMID:16619028, PMID:19851329, iPTMnet:Q14790] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16619028, PMID:19851329). Status=unreviewed. synonym: "hCASP8/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14790-1, Tyr-380, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q14790 ! caspase-8 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens