[Term] id: PR:P06240 name: proto-oncogene tyrosine-protein kinase LCK (mouse) def: "A tyrosine-protein kinase Lck that is encoded in the genome of mouse." [OMA:P06240, PRO:CNA] comment: Category=organism-gene. synonym: "Lck" RELATED Gene-based [UniProtKB:P06240] synonym: "mLCK" EXACT PRO-short-label [PRO:DNx] synonym: "Lsk-t" RELATED Gene-based [UniProtKB:P06240] synonym: "LSK (mouse)" EXACT [UniProtKB:P06240] synonym: "p56-LCK (mouse)" EXACT [UniProtKB:P06240] synonym: "leukocyte C-terminal Src kinase (mouse)" EXACT [UniProtKB:P06240] synonym: "lymphocyte cell-specific protein-tyrosine kinase (mouse)" EXACT [UniProtKB:P06240] xref: UniProtKB:P06240 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002998 ! tyrosine-protein kinase Lck relationship: has_gene_template MGI:96756 ! Lck (mouse) [Term] id: PR:000002998 name: tyrosine-protein kinase Lck def: "A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human LCK gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "LCK" EXACT PRO-short-label [PRO:DNx] synonym: "LSK" EXACT [] synonym: "Lsk-t" RELATED Gene-based [] synonym: "p56-LCK" EXACT [] synonym: "proto-oncogene Lck" EXACT [] synonym: "leukocyte C-terminal Src kinase" EXACT [] synonym: "T cell-specific protein-tyrosine kinase" EXACT [] synonym: "proto-oncogene tyrosine-protein kinase lck" EXACT [] synonym: "lymphocyte cell-specific protein-tyrosine kinase" EXACT [] xref: IUPHARobj:2053 is_a: PR:000002997 ! proto-oncogene SRC-like tyrosine-protein kinase [Term] id: PR:P06239-2 name: tyrosine-protein kinase Lck isoform Short (human) def: "A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-2." [PRO:DNx, UniProtKB:P06239] comment: Category=organism-sequence. synonym: "hLCK/iso:Short" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06239-2 is_a: PR:P06239 ! tyrosine-protein kinase Lck (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000003034 name: tyrosine-protein kinase Lck isoform 1 phosphorylated 2 def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated form in which the phosphorylation occurs at the activation Tyr residue (Tyr-394 in human lck). Example: UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL, PRO:DAN] comment: Category=modification. synonym: "lck active form" EXACT [] synonym: "LCK/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003000 ! tyrosine-protein kinase Lck isoform 1 phosphorylated form relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000002999 name: tyrosine-protein kinase Lck isoform 1 def: "A tyrosine-protein kinase Lck that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "LCK/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "LCK isoform Long" EXACT [] is_a: PR:000002998 ! tyrosine-protein kinase Lck [Term] id: PR:000045642 name: proto-oncogene tyrosine-protein kinase LCK phosphorylated 1 (mouse) def: "A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated at Tyr-505. UniProtKB:P06240, Tyr-505, MOD:00048." [PMID:8413300, iPTMnet:P06240] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:8413300). Status=unreviewed. synonym: "mLCK/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06240, Tyr-505, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P06240 ! proto-oncogene tyrosine-protein kinase LCK (mouse) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000048171 name: tyrosine-protein kinase Lck phosphorylated 2 (human) def: "A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-394, MOD:00048." [PRO:DNx, Reactome:R-HSA-202308, Reactome:R-HSA-8857940] comment: Category=organism-modification. synonym: "hLCK/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06239, Tyr-394, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-202308 "PR:000048171 located_in GO:0005829" xref: Reactome:R-HSA-8857940 "PR:000048171 located_in GO:0005886" is_a: PR:P06239 ! tyrosine-protein kinase Lck (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048172 name: tyrosine-protein kinase Lck phosphorylated 3 (human) def: "A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-505 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-505, MOD:00048." [PRO:DNx, Reactome:R-HSA-202159] comment: Category=organism-modification. synonym: "hLCK/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06239, Tyr-505, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-202159 "PR:000048172 located_in GO:0005886" is_a: PR:P06239 ! tyrosine-protein kinase Lck (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P06239-3 name: tyrosine-protein kinase Lck isoform h3 (human) def: "A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-3." [PRO:DNx, UniProtKB:P06239] comment: Category=organism-sequence. synonym: "hLCK/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06239-3 is_a: PR:P06239 ! tyrosine-protein kinase Lck (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036619 name: tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human) def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL] comment: Category=organism-modification. synonym: "hLCK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003001 ! tyrosine-protein kinase Lck isoform 1 phosphorylated 1 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000036622 name: tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human) def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL] comment: Category=organism-modification. synonym: "hLCK/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06239-1, Tyr-394, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003034 ! tyrosine-protein kinase Lck isoform 1 phosphorylated 2 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:Q01621 name: proto-oncogene tyrosine-protein kinase LCK (rat) def: "A tyrosine-protein kinase Lck that is encoded in the genome of rat." [OMA:Q01621, PRO:DNx] comment: Category=organism-gene. synonym: "Lck" RELATED Gene-based [UniProtKB:Q01621] synonym: "rLCK" EXACT PRO-short-label [PRO:DNx] synonym: "p56-LCK (rat)" EXACT [UniProtKB:Q01621] synonym: "lymphocyte cell-specific protein-tyrosine kinase (rat)" EXACT [UniProtKB:Q01621] xref: UniProtKB:Q01621 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002998 ! tyrosine-protein kinase Lck relationship: has_gene_template RGD:2994 ! Lck (rat) [Term] id: PR:000049825 name: proto-oncogene tyrosine-protein kinase LCK phosphorylated 3 (mouse) def: "A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated on the residue at the position equivalent to Tyr-192 of the amino acid sequence represented by UniProtKB:P06240. UniProtKB:P06240, Tyr-192, MOD:00048." [PMID:21183079, PRO:HJD] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079). Evidence=(ECO:0006055, based on PMID:21183079). synonym: "mLCK/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06240, Tyr-192, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P06240 ! proto-oncogene tyrosine-protein kinase LCK (mouse) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000049824 name: proto-oncogene tyrosine-protein kinase LCK phosphorylated 2 (mouse) def: "A proto-oncogene tyrosine-protein kinase LCK (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-35 of the amino acid sequence represented by UniProtKB:P06240. UniProtKB:P06240, Ser-35, MOD:00046." [PMID:21183079, PRO:HJD] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079). Evidence=(ECO:0006055, based on PMID:21183079). synonym: "mLCK/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P06240, Ser-35, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P06240 ! proto-oncogene tyrosine-protein kinase LCK (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000003001 name: tyrosine-protein kinase Lck isoform 1 phosphorylated 1 def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated form in which the phosphorylation occurs at the autoinhibitory Tyr residue (Tyr-505 in human lck), and in the activation Tyr residue (Tyr-394 in human lck). This form is predominant in the presence of HIV gp120 protein. Example: UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL, PRO:DAN] comment: Category=modification. synonym: "LCK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "lck autoinhibited" EXACT [] is_a: PR:000003000 ! tyrosine-protein kinase Lck isoform 1 phosphorylated form relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000003000 name: tyrosine-protein kinase Lck isoform 1 phosphorylated form def: "A tyrosine-protein kinase Lck isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "LCK/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000002999 ! tyrosine-protein kinase Lck isoform 1 [Term] id: PR:P06239-1 name: tyrosine-protein kinase Lck isoform Long (human) def: "A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hLCK/iso:Long" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06239-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002999 ! tyrosine-protein kinase Lck isoform 1 [Term] id: PR:P06239 name: tyrosine-protein kinase Lck (human) def: "A tyrosine-protein kinase Lck that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-gene. synonym: "LCK" RELATED Gene-based [UniProtKB:P06239] synonym: "hLCK" EXACT PRO-short-label [PRO:DNx] synonym: "LSK (human)" EXACT [UniProtKB:P06239] synonym: "p56-LCK (human)" EXACT [UniProtKB:P06239] synonym: "protein YT16 (human)" EXACT [UniProtKB:P06239] synonym: "proto-oncogene Lck (human)" EXACT [UniProtKB:P06239] synonym: "leukocyte C-terminal Src kinase (human)" EXACT [UniProtKB:P06239] synonym: "T cell-specific protein-tyrosine kinase (human)" EXACT [UniProtKB:P06239] synonym: "lymphocyte cell-specific protein-tyrosine kinase (human)" EXACT [UniProtKB:P06239] xref: Reactome:R-HSA-167609 "PR:P06239 located_in GO:0005829" xref: DTO:03100266 xref: UniProtKB:P06239 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002998 ! tyrosine-protein kinase Lck relationship: has_gene_template HGNC:6524 ! LCK (human) [Term] id: PR:P06240-1 name: proto-oncogene tyrosine-protein kinase LCK isoform 1 (mouse) def: "A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mLCK/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P06240-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002999 ! tyrosine-protein kinase Lck isoform 1