[Term]
id: PR:P06241
name: tyrosine-protein kinase Fyn (human)
def: "A tyrosine-protein kinase Fyn that is encoded in the genome of human." [PRO:CNA, UniProtKB:P06241]
comment: Category=organism-gene.
synonym: "FYN" RELATED Gene-based [UniProtKB:P06241]
synonym: "hFYN" EXACT PRO-short-label [PRO:DNx]
synonym: "SLK (human)" EXACT [UniProtKB:P06241]
synonym: "p59-Fyn (human)" EXACT [UniProtKB:P06241]
synonym: "Src-like kinase (human)" EXACT [UniProtKB:P06241]
synonym: "proto-oncogene Syn (human)" EXACT [UniProtKB:P06241]
synonym: "proto-oncogene c-Fyn (human)" EXACT [UniProtKB:P06241]
xref: DTO:03100156
xref: UniProtKB:P06241
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003003 ! tyrosine-protein kinase Fyn
relationship: has_gene_template HGNC:4037 ! FYN (human)

[Term]
id: PR:P06241-2
name: tyrosine-protein kinase Fyn isoform 2 (human)
def: "A tyrosine-protein kinase Fyn isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hFYN/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase Fyn isoform T (human)" EXACT [UniProtKB:P06241]
xref: UniProtKB:P06241-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038689 ! tyrosine-protein kinase Fyn isoform 2

[Term]
id: PR:000036620
name: tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 (human)
def: "A tyrosine-protein kinase Fyn isoform 1 phosphorylated 1 in human." [PMID:9043947, PRO:CL]
comment: Category=organism-modification.
synonym: "hFYN/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003006 ! tyrosine-protein kinase Fyn isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000047467
name: tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 3 (human)
def: "A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-391821]
comment: Category=organism-modification.
synonym: "hFYN/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088099, Tyr-420, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P06241, 2-537, Tyr-420, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-391821 "PR:000047467 located_in GO:0005829"
is_a: PR:P06241 ! tyrosine-protein kinase Fyn (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047466
name: tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 2 (human)
def: "A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 21, and phosphotyrosine at position 420 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Ser-21, MOD:00046|Tyr-420, MOD:00048." [PRO:DNx, Reactome:R-HSA-5218745]
comment: Category=organism-modification.
synonym: "hFYN/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088099, Ser-21, MOD:00046|Tyr-420, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P06241, 2-537, Ser-21, MOD:00046|Tyr-420, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218745 "PR:000047466 located_in GO:0005829"
is_a: PR:P06241 ! tyrosine-protein kinase Fyn (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047465
name: tyrosine-protein kinase Fyn, initiator methionine removed form (human)
def: "A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed. UniProtKB:P06241, 2-537." [PRO:DNx, Reactome:R-HSA-200917]
comment: Category=organism-modification.
synonym: "hFYN/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088099" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P06241, 2-537" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-200917 "PR:000047465 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P06241 ! tyrosine-protein kinase Fyn (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06241-1
name: tyrosine-protein kinase Fyn isoform 1 (human)
def: "A tyrosine-protein kinase Fyn isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hFYN/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "tyrosine-protein kinase Fyn isoform B (human)" EXACT [UniProtKB:P06241]
xref: UniProtKB:P06241-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003004 ! tyrosine-protein kinase Fyn isoform 1

[Term]
id: PR:000003003
name: tyrosine-protein kinase Fyn
def: "A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human FYN gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "FYN" EXACT PRO-short-label [PRO:DNx]
synonym: "SLK" BROAD [PRO:DNx]
synonym: "p59-Fyn" EXACT []
synonym: "proto-oncogene Syn" EXACT []
synonym: "proto-oncogene c-Fyn" EXACT []
xref: IUPHARobj:2026
is_a: PR:000002997 ! proto-oncogene SRC-like tyrosine-protein kinase

[Term]
id: PR:000047468
name: tyrosine-protein kinase Fyn, initiator methionine removed phosphorylated 4 (human)
def: "A tyrosine-protein kinase Fyn (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphotyrosine at position 531 of the amino acid sequence represented by UniProtKB:P06241. UniProtKB:P06241, 2-537, Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-391819]
comment: Category=organism-modification.
synonym: "hFYN/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000088099, Tyr-531, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P06241, 2-537, Tyr-531, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-391819 "PR:000047468 located_in GO:0005829"
is_a: PR:P06241 ! tyrosine-protein kinase Fyn (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P06241-3
name: tyrosine-protein kinase Fyn isoform h3 (human)
def: "A tyrosine-protein kinase Fyn (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06241-3." [PRO:DNx, UniProtKB:P06241]
comment: Category=organism-sequence.
synonym: "hFYN/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06241-3
is_a: PR:P06241 ! tyrosine-protein kinase Fyn (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens