[Term] id: PR:000027807 name: cellular tumor antigen p53 isoform 1 methylated 3 def: "A cellular tumor antigen p53 isoform 1 that has been methylated at the second Lys residue of the [KR]-[STA]-K motif within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Me:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00663 ! methylated lysine [Term] id: PR:000027806 name: cellular tumor antigen p53 isoform 1 ubiquitinated 1 (human) def: "A cellular tumor antigen p53 isoform 1 ubiquitinated 1 in human. UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD] comment: Category=organism-modification. UbLigase=("MKRN1"; PR:Q9UHC7; Lys-291/Lys-292). synonym: "hTP53/iso:1/Ubiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "p53-uLys291-uLys292" EXACT [PMID:19536131] synonym: "UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027805 ! cellular tumor antigen p53 isoform 1 ubiquitinated 1 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000027805 name: cellular tumor antigen p53 isoform 1 ubiquitinated 1 def: "A cellular tumor antigen p53 isoform 1 that has been ubiquitinated at two highly conserved Lys residues in the C-terminal region of the DNA-binding domain. This modification promotes proteasomal degradation of p53. Example: UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Ubiq:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000049521 name: cellular tumor antigen p53 phosphorylated 12 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15 and 392 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-392, MOD:00046." [PRO:DNx, Reactome:R-HSA-3222015] comment: Category=organism-modification. synonym: "hTP53/Phos:12" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3222015 "PR:000049521 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027846 name: cellular tumor antigen p53 isoform 1 unmodified form (human) def: "A cellular tumor antigen p53 isoform 1 unmodified form in human." [PMID:19339993, PRO:CNA] comment: Category=organism-modification. synonym: "hTP53/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003037 ! cellular tumor antigen p53 isoform 1 unmodified form [Term] id: PR:000027809 name: cellular tumor antigen p53 isoform 1 methylated 4 def: "A cellular tumor antigen p53 isoform 1 that has been methylated at the first Lys residue of the K-[STA]-K within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Me:4" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00663 ! methylated lysine [Term] id: PR:000027808 name: cellular tumor antigen p53 isoform 1 methylated 3 (human) def: "A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD] comment: Category=organism-modification. Methylase=("SETD7"; PR:Q8WTS6; Lys-372). synonym: "p53-mLys372" EXACT [] synonym: "hTP53/iso:1/Me:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-372, MOD:00663" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027807 ! cellular tumor antigen p53 isoform 1 methylated 3 relationship: has_part MOD:00663 ! methylated lysine [Term] id: PR:000035446 name: cellular tumor antigen p53 isoform 1 phosphorylated 1 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 1 in human. Phosphorylated form found upon DNA damage. UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:22099307, PRO:KER] comment: Category=organism-modification. Kinase=("ATM"; PR:Q13315). synonym: "p53S15 (human)" EXACT [] synonym: "hTP53/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003039 ! cellular tumor antigen p53 isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027841 name: cellular tumor antigen p53 isoform 1 sumoylated 1 (human) def: "A cellular tumor antigen p53 isoform 1 sumoylated 1 in human. UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD] comment: Category=organism-modification. synonym: "p53-sLys386" EXACT [] synonym: "hTP53/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-386, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027840 ! cellular tumor antigen p53 isoform 1 sumoylated 1 relationship: has_part MOD:01149 ! sumoylated lysine [Term] id: PR:000027840 name: cellular tumor antigen p53 isoform 1 sumoylated 1 def: "A cellular tumor antigen p53 isoform 1 that has been sumoylated on a conserved Lys residue located within the regulatory C-terminal domain. While p53 sumoylation at Lys386 inhibits p300 mediated p53 acetylation (at Lys382 and Lys 373), p53 acetylation by p300 remains permissive for subsequent Lys386 sumoylation. Lys386 sumoylated p53 exists as a tetramer in solution. Example: UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:01149 ! sumoylated lysine [Term] id: PR:P04637-8 name: cellular tumor antigen p53 isoform h8 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-8." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h8" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform Del133-p53beta (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-8 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04637-9 name: cellular tumor antigen p53 isoform h9 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-9." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h9" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform Del133-p53gamma (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-9 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049519 name: cellular tumor antigen p53 phosphorylated 16 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 46 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-46, MOD:00046." [PRO:DNx, Reactome:R-HSA-6798369] comment: Category=organism-modification. synonym: "hTP53/Phos:16" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6798369 "PR:000049519 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049518 name: cellular tumor antigen p53 phosphorylated 15 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 392 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-392, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805053] comment: Category=organism-modification. synonym: "hTP53/Phos:15" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805053 "PR:000049518 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04637-1 name: cellular tumor antigen p53 isoform 1 (human) def: "A cellular tumor antigen p53 isoform 1 that is encoded in the genome of human." [PMID:17671183, PMID:19252416, PRO:KER] comment: Category=organism-sequence. synonym: "hTP53/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04637-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003036 ! cellular tumor antigen p53 isoform 1 [Term] id: PR:000049515 name: cellular tumor antigen p53 phosphorylated 1 (human) def: "A cellular tumor antigen p53 (human) that has been phosphorylated on the residue at the position equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15, MOD:00046." [PRO:DNx, Reactome:R-HSA-69507] comment: Category=organism-modification. synonym: "hTP53/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-69507 "PR:000049515 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049514 name: cellular tumor antigen p53 dimethylated 2 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include dimethyl-L-lysine at position 373 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-373, MOD:00084." [PRO:DNx, Reactome:R-HSA-6805759] comment: Category=organism-modification. synonym: "hTP53/Me2:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Lys-373, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805759 "PR:000049514 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049517 name: cellular tumor antigen p53 phosphorylated 14 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 269, and phosphothreonine at position 284 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-269, MOD:00046|Thr-284, MOD:00047." [PRO:DNx, Reactome:R-HSA-6805133] comment: Category=organism-modification. synonym: "hTP53/Phos:14" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-269, MOD:00046|Thr-284, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805133 "PR:000049517 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049516 name: cellular tumor antigen p53 phosphorylated 13 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15 and 20 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20, MOD:00046." [PRO:DNx, Reactome:R-HSA-69683] comment: Category=organism-modification. synonym: "hTP53/Phos:13" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-20, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-69683 "PR:000049516 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04637-4 name: cellular tumor antigen p53 isoform h4 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-4." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h4" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform p47 (human)" EXACT [UniProtKB:P04637] synonym: "cellular tumor antigen p53 isoform Del40-p53 (human)" EXACT [UniProtKB:P04637] synonym: "cellular tumor antigen p53 isoform Del40-p53alpha (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-4 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04637-2 name: cellular tumor antigen p53 isoform h2 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-2." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform I9RET (human)" EXACT [UniProtKB:P04637] synonym: "cellular tumor antigen p53 isoform p53beta (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-2 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049513 name: cellular tumor antigen p53 dimethylated 3 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include dimethyl-L-lysine at positions 370 and 382 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-370/Lys-382, MOD:00084." [PRO:DNx, Reactome:R-HSA-3222242] comment: Category=organism-modification. synonym: "hTP53/Me2:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Lys-370/Lys-382, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3222242 "PR:000049513 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04637-7 name: cellular tumor antigen p53 isoform h7 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-7." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h7" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform Del133-p53 (human)" EXACT [UniProtKB:P04637] synonym: "cellular tumor antigen p53 isoform Del133-p53alpha (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-7 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027771 name: cellular tumor antigen p53 isoform 1 phosphorylated 6 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at the Ser residue within the S10 beta strand located in the DNA binding domain (Pfam:PF00870). Example: UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027770 name: cellular tumor antigen p53 isoform 1 phosphorylated 5 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 5 in human. UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD] comment: Category=organism-modification. synonym: "p53-pSer15-pThr18" EXACT [] synonym: "hTP53/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027769 ! cellular tumor antigen p53 isoform 1 phosphorylated 5 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027773 name: cellular tumor antigen p53 isoform 1 acetylated 1 def: "A cellular tumor antigen p53 isoform 1 that has been acetylated on a Lys residue within the DNA binding domain (Pfam:PF00870) in response to genotoxic stress. Example: UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000027772 name: cellular tumor antigen p53 isoform 1 phosphorylated 6 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 6 in human. UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD] comment: Category=organism-modification. synonym: "p53-pSer269" EXACT [] synonym: "hTP53/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-269, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027771 ! cellular tumor antigen p53 isoform 1 phosphorylated 6 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027774 name: cellular tumor antigen p53 isoform 1 acetylated 1 (human) def: "A cellular tumor antigen p53 isoform 1 acetylated 1 in human. UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD] comment: Category=organism-modification. Acetylase=("MYST1"; PR:Q9H7Z6). synonym: "p53-acLys120" EXACT [] synonym: "hTP53/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-120, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027773 ! cellular tumor antigen p53 isoform 1 acetylated 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000003036 name: cellular tumor antigen p53 isoform 1 def: "A cellular tumor antigen p53 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "TP53/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003035 ! cellular tumor antigen p53 [Term] id: PR:000003037 name: cellular tumor antigen p53 isoform 1 unmodified form def: "A cellular tumor antigen p53 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA] comment: Category=modification. synonym: "unmodified p53" EXACT [PMID:19339993] synonym: "TP53/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000003036 ! cellular tumor antigen p53 isoform 1 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000003038 name: cellular tumor antigen p53 isoform 1 phosphorylated form def: "A cellular tumor antigen p53 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "TP53/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000003036 ! cellular tumor antigen p53 isoform 1 [Term] id: PR:000003039 name: cellular tumor antigen p53 isoform 1 phosphorylated 1 def: "A cellular tumor antigen p53 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:P04637-1. Example: UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:11602639, PRO:CL, PRO:DAN] comment: Category=modification. synonym: "p53S15" EXACT [] synonym: "TP53/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003038 ! cellular tumor antigen p53 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000049524 name: cellular tumor antigen p53 phosphorylated 4 (human) def: "A cellular tumor antigen p53 (human) that has been phosphorylated on the residue at the position equivalent to Thr-55 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Thr-55, MOD:00047." [PRO:DNx, Reactome:R-HSA-6805400] comment: Category=organism-modification. synonym: "hTP53/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Thr-55, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805400 "PR:000049524 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027828 name: cellular tumor antigen p53 isoform 1 phosphorylated 7 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at multiple Ser residues, one within the N-terminal transactivation domain and other two in the C-terminal region of p53. Example: UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:7" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P04637-3 name: cellular tumor antigen p53 isoform h3 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-3." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform p53gamma (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-3 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P10361 name: cellular tumor antigen p53 (rat) def: "A cellular tumor antigen p53 that is encoded in the genome of rat." [PANTHER:PTHR11447:SF6, PRO:DNx] comment: Category=organism-gene. synonym: "P53" RELATED Gene-based [UniProtKB:P10361] synonym: "Tp53" RELATED Gene-based [UniProtKB:P10361] synonym: "rTP53" EXACT PRO-short-label [PRO:DNx] synonym: "tumor suppressor p53 (rat)" EXACT [UniProtKB:P10361] xref: UniProtKB:P10361 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000003035 ! cellular tumor antigen p53 relationship: has_gene_template RGD:3889 ! Tp53 (rat) [Term] id: PR:P04637-6 name: cellular tumor antigen p53 isoform h6 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-6." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h6" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform Del40-p53gamma (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-6 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027838 name: cellular tumor antigen p53 isoform 1 phosphorylated 11 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at multiple conserved sites within the DNA-binding domain. Example: UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:11" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027839 name: cellular tumor antigen p53 isoform 1 phosphorylated 11 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 11 in human. UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD] comment: Category=organism-modification. Kinase=("AURKB"; PR:Q96GD4). synonym: "hTP53/iso:1/Phos:11" EXACT PRO-short-label [PRO:DNx] synonym: "p53-pSer183-pSer269-pThr284" EXACT [] synonym: "UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027838 ! cellular tumor antigen p53 isoform 1 phosphorylated 11 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027836 name: cellular tumor antigen p53 isoform 1 phosphorylated 10 def: "A cellular tumor antigen p53 isoform 1 that is phosphorylated at multiple Ser residues located in the N-terminal region of p53 in response to DNA damage. The tetramerization domain of p53 is required for efficient phosphorylation at these 3 Ser residues. Example: UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:10" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027837 name: cellular tumor antigen p53 isoform 1 phosphorylated 10 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 10 in human. UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD] comment: Category=organism-modification. synonym: "hTP53/iso:1/Phos:10" EXACT PRO-short-label [PRO:DNx] synonym: "p53-pSer15-pSer20-pSer33" EXACT [] synonym: "UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027836 ! cellular tumor antigen p53 isoform 1 phosphorylated 10 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027834 name: cellular tumor antigen p53 isoform 1 O-glycosylated 1 def: "A cellular tumor antigen p53 isoform 1 that has been O-glycosylated on a Ser residue located in the DNA-binding domain. This modification stabilizes p53 by blocking ubiquitin-dependent proteolysis and also inhibits phosphorylation of p53 at Thr-155. Example: UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:DAN, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00805 ! O-(N-acetylamino)glucosyl-L-serine [Term] id: PR:000027835 name: cellular tumor antigen p53 isoform 1 O-glycosylated 1 (human) def: "A cellular tumor antigen p53 isoform 1 O-glycosylated 1 in human. UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:PD] comment: Category=organism-modification. synonym: "p53-gSer149" EXACT [] synonym: "hTP53/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027834 ! cellular tumor antigen p53 isoform 1 O-glycosylated 1 relationship: has_part MOD:00805 ! O-(N-acetylamino)glucosyl-L-serine [Term] id: PR:000027832 name: cellular tumor antigen p53 isoform 1 phosphorylated 9 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated on two Ser residues in the N-terminal transactivation domain in response to gamma-irradiation. Example: UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:9" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027833 name: cellular tumor antigen p53 isoform 1 phosphorylated 9 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 9 in human. UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD] comment: Category=organism-modification. synonym: "p53-pSer15-pSer37" EXACT [] synonym: "hTP53/iso:1/Phos:9" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027832 ! cellular tumor antigen p53 isoform 1 phosphorylated 9 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027830 name: cellular tumor antigen p53 isoform 1 phosphorylated 8 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at two Ser residues, one located in the DNA-binding domain and the other within the nuclear localization signal of the C-terminus of p53. Phosphorylation at Ser-215 hinders DNA binding and transactivation activity of p53. Example: UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027831 name: cellular tumor antigen p53 isoform 1 phosphorylated 8 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 8 in human. UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD] comment: Category=organism-modification. Kinase=("AURKA"; PR:O14965). synonym: "hTP53/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx] synonym: "p53-pSer215-pSer315" EXACT [] synonym: "UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027830 ! cellular tumor antigen p53 isoform 1 phosphorylated 8 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027810 name: cellular tumor antigen p53 isoform 1 methylated 4 (human) def: "A cellular tumor antigen p53 isoform 1 methylated 4 in human. UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD] comment: Category=organism-modification. Methylase=("SMYD2"; PR:Q9NRG4). synonym: "p53-mLys370" EXACT [] synonym: "hTP53/iso:1/Me:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-370, MOD:00663" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027809 ! cellular tumor antigen p53 isoform 1 methylated 4 relationship: has_part MOD:00663 ! methylated lysine [Term] id: PR:000027811 name: cellular tumor antigen p53 isoform 1 acetylated 2 def: "A cellular tumor antigen p53 isoform 1 that has been acetylated on a Lys residue within the C-terminal regulatory region. Example: UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000027812 name: cellular tumor antigen p53 isoform 1 acetylated 2 (human) def: "A cellular tumor antigen p53 isoform 1 acetylated 2 in human. UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD] comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472; Lys-382). synonym: "p53-acLys382" EXACT [] synonym: "hTP53/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-382, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027811 ! cellular tumor antigen p53 isoform 1 acetylated 2 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000027813 name: cellular tumor antigen p53 isoform 1 phosphorylated 12 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at two Ser residues, one located in the N-terminal transactivation domain and the other in the C-terminal region of p53. Example: UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:12" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027814 name: cellular tumor antigen p53 isoform 1 phosphorylated 12 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 12 in human. UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD] comment: Category=organism-modification. Kinase=("NUAK1"; PR:O60285; Ser-15/Ser-392). synonym: "p53-pSer15-pSer392" EXACT [] synonym: "hTP53/iso:1/Phos:12" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027813 ! cellular tumor antigen p53 isoform 1 phosphorylated 12 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000049525 name: cellular tumor antigen p53 sumoylated 1 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include sumoylated lysine at position 386 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-386, MOD:01149." [PRO:DNx, Reactome:R-HSA-2997661] comment: Category=organism-modification. synonym: "hTP53/Sumo:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Lys-386, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2997661 "PR:000049525 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:01149 ! sumoylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049526 name: cellular tumor antigen p53 ubiquitinated form (human) def: "A cellular tumor antigen p53 (human) that includes at least one ubiquitinated lysine. UniProtKB:P04637, MOD:01148." [PRO:DNx, Reactome:R-HSA-6793681] comment: Category=organism-modification. synonym: "hTP53/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6793681 "PR:000049526 located_in GO:0005829" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000045628 name: cellular tumor antigen p53 phosphorylated 1 (mouse) def: "A cellular tumor antigen p53 (mouse) that has been phosphorylated at Ser-389. UniProtKB:P02340, Ser-389, MOD:00046." [PMID:10094408, iPTMnet:P02340] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10094408). Note: The modified site indicated here (Ser-389) is referred to as Ser-386 in some manuscripts. [PRO:DAN, PMID:10094408] synonym: "mTP53/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02340, Ser-389, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:P02340 ! cellular tumor antigen p53 (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000036624 name: cellular tumor antigen p53 isoform 1 phosphorylated 2 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 2 in human. UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL] comment: Category=organism-modification. synonym: "hTP53/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003040 ! cellular tumor antigen p53 isoform 1 phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000027763 name: cellular tumor antigen p53 isoform 1 phosphorylated 3 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at the Thr residue in the motif PTPAAPAPAPSWPLSS. This modification stabilizes p53 in response to stress. Example: UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027766 name: cellular tumor antigen p53 isoform 1 dimethylated 1 (human) def: "A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD] comment: Category=organism-modification. synonym: "p53K382me2" EXACT [] synonym: "hTP53/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-382, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027765 ! cellular tumor antigen p53 isoform 1 dimethylated 1 relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine [Term] id: PR:000027767 name: cellular tumor antigen p53 isoform 1 phosphorylated 4 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated on a Thr residue in the N-terminal activation domain 2 (AD2). This modification promotes MDM2-mediated p53 degradation and TAF1-mediated cell cycle progression. Example: UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027764 name: cellular tumor antigen p53 isoform 1 phosphorylated 3 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 3 in human. UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:PD] comment: Category=organism-modification. Kinase=("JNK"). synonym: "p53alpha pT81" EXACT [] synonym: "hTP53/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Thr-81, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027763 ! cellular tumor antigen p53 isoform 1 phosphorylated 3 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027765 name: cellular tumor antigen p53 isoform 1 dimethylated 1 def: "A cellular tumor antigen p53 isoform 1 that has been dimethylated on a Lys residue present in the [KR]Kx(2)[LF]K[TR] sequence within the C-terminal regulatory region. This modification may promote p53 stability in response to DNA damage signals. Example: UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine [Term] id: PR:000049520 name: cellular tumor antigen p53 phosphorylated 17 (human) def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 33 and 46 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-33/Ser-46, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805268] comment: Category=organism-modification. synonym: "hTP53/Phos:17" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-15/Ser-33/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805268 "PR:000049520 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000003040 name: cellular tumor antigen p53 isoform 1 phosphorylated 2 def: "A cellular tumor antigen p53 isoform 1 phosphorylated form in which the phosphorylation occurs at residues equivalent to Ser-15/Ser-46 of the amino acid sequence represented by UniProtKB:P04637-1. Example: UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL, PRO:DAN] comment: Category=modification. synonym: "p53S46P" EXACT [] synonym: "TP53/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003038 ! cellular tumor antigen p53 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000049522 name: cellular tumor antigen p53 phosphorylated 18 (human) def: "A cellular tumor antigen p53 (human) that has been phosphorylated on the residue at the position equivalent to Ser-315 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-315, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805106] comment: Category=organism-modification. synonym: "hTP53/Phos:18" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-315, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6805106 "PR:000049522 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049523 name: cellular tumor antigen p53 phosphorylated 19 (human) def: "A cellular tumor antigen p53 (human) that has been phosphorylated on the residue at the position equivalent to Ser-37 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-37, MOD:00046." [PRO:DNx, Reactome:R-HSA-3239022] comment: Category=organism-modification. synonym: "hTP53/Phos:19" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637, Ser-37, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3239022 "PR:000049523 located_in GO:0005654" is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000050231 name: cellular tumor antigen p53 acetylated 2 (mouse) def: "A cellular tumor antigen p53 (mouse) that has been acetylated at the position equivalent to Lys-379 of the amino acid sequence represented by UniProtKB:P02340. UniProtKB:P02340, Lys-379, MOD:00064." [PMID:26919979, PRO:LN] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26919979). synonym: "mTP53/Ac:2" EXACT PRO-short-label [PRO:KER] synonym: "UniProtKB:P02340, Lys-379, MOD:00064" EXACT PRO-proteoform-std [PRO:KER] is_a: PR:P02340 ! cellular tumor antigen p53 (mouse) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:P79734 name: cellular tumor antigen p53 (zebrafish) def: "A cellular tumor antigen p53 that is encoded in the genome of zebrafish." [PANTHER:PTHR11447:SF6, PRO:DNx] comment: Category=organism-gene. synonym: "tp53" RELATED Gene-based [UniProtKB:P79734] synonym: "drp53" RELATED Gene-based [UniProtKB:P79734] synonym: "z-TP53" EXACT PRO-short-label [PRO:DNx] synonym: "tumor suppressor p53 (zebrafish)" EXACT [UniProtKB:P79734] xref: UniProtKB:P79734 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000003035 ! cellular tumor antigen p53 relationship: has_gene_template ZFIN:ZDB-GENE-990415-270 ! tp53 (zebrafish) [Term] id: PR:P04637-5 name: cellular tumor antigen p53 isoform h5 (human) def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-5." [PRO:DNx, UniProtKB:P04637] comment: Category=organism-sequence. synonym: "hTP53/iso:h5" EXACT PRO-short-label [PRO:DNx] synonym: "cellular tumor antigen p53 isoform Del40-p53beta (human)" EXACT [UniProtKB:P04637] xref: UniProtKB:P04637-5 is_a: PR:P04637 ! cellular tumor antigen p53 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027768 name: cellular tumor antigen p53 isoform 1 phosphorylated 4 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 4 in human. UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD] comment: Category=organism-modification. Kinase=("TAF1"; PR:P21675; Thr-55). synonym: "p53-pThr55" EXACT [] synonym: "hTP53/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Thr-55, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027767 ! cellular tumor antigen p53 isoform 1 phosphorylated 4 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027769 name: cellular tumor antigen p53 isoform 1 phosphorylated 5 def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at Ser and Thr residues in the highly conserved PLSQETF motif in the N-terminal activation domain 1 (AD1). Phosphorylation at Thr residue is dependent on the prior phosphorylation of the Ser residue. Example: UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000027829 name: cellular tumor antigen p53 isoform 1 phosphorylated 7 (human) def: "A cellular tumor antigen p53 isoform 1 phosphorylated 7 in human. UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD] comment: Category=organism-modification. Kinase=("CDK9"; PR:P50750). synonym: "hTP53/iso:1/Phos:7" EXACT PRO-short-label [PRO:DNx] synonym: "p53-pSer33-pSer315-pSer392" EXACT [] synonym: "UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027828 ! cellular tumor antigen p53 isoform 1 phosphorylated 7 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000003035 name: cellular tumor antigen p53 def: "A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "P53" RELATED Gene-based [] synonym: "TP53" EXACT PRO-short-label [PRO:DNx] synonym: "Trp53" RELATED Gene-based [] synonym: "antigen NY-CO-13" EXACT [] synonym: "phosphoprotein p53" EXACT [] synonym: "tumor suppressor p53" EXACT [] xref: PIRSF:PIRSF002089 is_a: PR:000000001 ! protein [Term] id: PR:P10360 name: cellular tumor antigen p53 (chicken) def: "A cellular tumor antigen p53 that is encoded in the genome of chicken." [PANTHER:PTHR11447:SF6, PRO:DNx] comment: Category=organism-gene. synonym: "TP53" RELATED Gene-based [UniProtKB:P10360] synonym: "chick-TP53" EXACT PRO-short-label [PRO:DNx] synonym: "tumor suppressor p53 (chicken)" EXACT [UniProtKB:P10360] xref: UniProtKB:P10360 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000003035 ! cellular tumor antigen p53 relationship: has_gene_template CGNC:49696 ! TP53 (chicken) [Term] id: PR:P04637 name: cellular tumor antigen p53 (human) def: "A cellular tumor antigen p53 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P04637] comment: Category=organism-gene. synonym: "P53" RELATED Gene-based [UniProtKB:P04637] synonym: "TP53" RELATED Gene-based [UniProtKB:P04637] synonym: "hTP53" EXACT PRO-short-label [PRO:DNx] synonym: "antigen NY-CO-13 (human)" EXACT [UniProtKB:P04637] synonym: "phosphoprotein p53 (human)" EXACT [UniProtKB:P04637] synonym: "tumor suppressor p53 (human)" EXACT [UniProtKB:P04637] xref: Reactome:R-HSA-69488 "PR:P04637 located_in GO:0005654" xref: Reactome:R-HSA-6813797 "PR:P04637 located_in GO:0005829" xref: Reactome:R-HSA-8869337 "PR:P04637 located_in GO:0005829" xref: UniProtKB:P04637 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003035 ! cellular tumor antigen p53 relationship: has_gene_template HGNC:11998 ! TP53 (human) [Term] id: PR:P02340 name: cellular tumor antigen p53 (mouse) def: "A cellular tumor antigen p53 that is encoded in the genome of mouse." [OMA:P02340, PRO:CNA] comment: Category=organism-gene. synonym: "P53" RELATED Gene-based [UniProtKB:P02340] synonym: "Tp53" RELATED Gene-based [UniProtKB:P02340] synonym: "Trp53" RELATED Gene-based [UniProtKB:P02340] synonym: "mTP53" EXACT PRO-short-label [PRO:DNx] synonym: "tumor suppressor p53 (mouse)" EXACT [UniProtKB:P02340] xref: UniProtKB:P02340 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003035 ! cellular tumor antigen p53 relationship: has_gene_template MGI:98834 ! Trp53 (mouse) [Term] id: PR:000027827 name: cellular tumor antigen p53 isoform 1 dimethylated 2 (human) def: "A cellular tumor antigen p53 isoform 1 dimethylated 2 in human. UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD] comment: Category=organism-modification. Methylase=("EHMT1"; PR:Q9H9B1; Lys-373). Methylase=("EHMT2"; PR:Q96KQ7; Lys-373). synonym: "p53-me2Lys373" EXACT [] synonym: "hTP53/iso:1/Me2:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04637-1, Lys-373, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027826 ! cellular tumor antigen p53 isoform 1 dimethylated 2 relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine [Term] id: PR:000027826 name: cellular tumor antigen p53 isoform 1 dimethylated 2 def: "A cellular tumor antigen p53 isoform 1 that has been dimethylated on a Lys residue within the regulatory domain at the C terminus. Example: UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD] comment: Category=modification. synonym: "TP53/iso:1/Me2:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1 relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine