[Term]
id: PR:000003058
name: protein kinase C alpha type
def: "A conventional protein kinase C that is a translation product of the human PRKCA gene or a 1:1 ortholog thereof." [PRO:CL]
comment: Category=gene.
synonym: "PKCA" RELATED Gene-based []
synonym: "PKC-A" EXACT []
synonym: "PRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKACA" RELATED Gene-based []
synonym: "PKC-alpha" EXACT []
synonym: "protein kinase Calpha" EXACT [PMID:9648724]
xref: IUPHARobj:1482
is_a: PR:000003057 ! conventional protein kinase C

[Term]
id: PR:P20444
name: protein kinase C alpha type (mouse)
def: "A protein kinase C alpha type that is encoded in the genome of mouse." [OMA:P20444, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pkca" RELATED Gene-based [UniProtKB:P20444]
synonym: "Prkca" RELATED Gene-based [UniProtKB:P20444]
synonym: "mPRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-A (mouse)" EXACT [UniProtKB:P20444]
synonym: "PKC-alpha (mouse)" EXACT [UniProtKB:P20444]
xref: UniProtKB:P20444
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template MGI:97595 ! Prkca (mouse)

[Term]
id: PR:P05130-2
name: protein kinase C, brain isozyme isoform Short (fruit fly)
def: "A protein kinase C, brain isozyme (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05130-2." [PRO:DNx, UniProtKB:P05130]
comment: Category=organism-sequence.
synonym: "fly-PRKCA/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05130-2
is_a: PR:P05130 ! protein kinase C, brain isozyme (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P05130-1
name: protein kinase C, brain isozyme isoform Long (fruit fly)
def: "A protein kinase C, brain isozyme (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05130-1." [PRO:DNx, UniProtKB:P05130]
comment: Category=organism-sequence.
synonym: "fly-PRKCA/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05130-1
is_a: PR:P05130 ! protein kinase C, brain isozyme (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:P90980-3
name: protein kinase C-like 2 isoform c (worm)
def: "A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-3." [PRO:DNx, UniProtKB:P90980]
comment: Category=organism-sequence.
synonym: "PRKCA/iso:c (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P90980-3
is_a: PR:P90980 ! protein kinase C-like 2 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P05696
name: protein kinase C alpha type (rat)
def: "A protein kinase C alpha type that is encoded in the genome of rat." [OMA:P05696, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pkca" RELATED Gene-based [UniProtKB:P05696]
synonym: "Prkca" RELATED Gene-based [UniProtKB:P05696]
synonym: "rPRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-A (rat)" EXACT [UniProtKB:P05696]
synonym: "PKC-alpha (rat)" EXACT [UniProtKB:P05696]
xref: UniProtKB:P05696
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template RGD:3395 ! Prkca (rat)

[Term]
id: PR:P17252-1
name: protein kinase C alpha type isoform 1 (human)
def: "A protein kinase C alpha type isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRKCA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P17252-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038974 ! protein kinase C alpha type isoform 1

[Term]
id: PR:P90980-1
name: protein kinase C-like 2 isoform b (worm)
def: "A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-1." [PRO:DNx, UniProtKB:P90980]
comment: Category=organism-sequence.
synonym: "PRKCA/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "protein kinase C-like 2 isoform PKC2B (worm)" EXACT [UniProtKB:P90980]
xref: UniProtKB:P90980-1
is_a: PR:P90980 ! protein kinase C-like 2 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:P17252
name: protein kinase C alpha type (human)
def: "A protein kinase C alpha type that is encoded in the genome of human." [PRO:CL, UniProtKB:P17252]
comment: Category=organism-gene.
synonym: "PKCA" RELATED Gene-based [UniProtKB:P17252]
synonym: "PRKCA" RELATED Gene-based [UniProtKB:P17252]
synonym: "PRKACA" RELATED Gene-based [UniProtKB:P17252]
synonym: "hPRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-A (human)" EXACT [UniProtKB:P17252]
synonym: "PKC-alpha (human)" EXACT [UniProtKB:P17252]
xref: DTO:03100236
xref: UniProtKB:P17252
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template HGNC:9393 ! PRKCA (human)

[Term]
id: PR:000046148
name: protein kinase C alpha type phosphorylated 1 (mouse)
def: "A protein kinase C alpha type (mouse) that has been phosphorylated at Thr-638. UniProtKB:P20444, Thr-638, MOD:00047." [PMID:20513439, iPTMnet:P20444]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20513439). Status=unreviewed.
synonym: "mPRKCA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P20444, Thr-638, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P20444 ! protein kinase C alpha type (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000018782
name: protein kinase C alpha type, initiator methionine removed form
def: "A protein kinase C alpha type that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "PRKCA/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003058 ! protein kinase C alpha type
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P90980
name: protein kinase C-like 2 (worm)
def: "A protein kinase C alpha type that is encoded in the genome of worm." [PRO:CL]
comment: Category=organism-gene.
synonym: "pkc-2" RELATED Gene-based [UniProtKB:P90980]
synonym: "kin-11" RELATED Gene-based [UniProtKB:P90980]
synonym: "E01H11.1" RELATED Gene-based [UniProtKB:P90980]
synonym: "PKC2 (worm)" EXACT [UniProtKB:P90980]
synonym: "PRKCA (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P90980
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template WormBase:WBGene00004033 ! pkc-2 (worm)

[Term]
id: PR:P05130
name: protein kinase C, brain isozyme (fruit fly)
def: "A protein kinase C alpha type that is encoded in the genome of fruit fly." [PRO:CL]
comment: Category=organism-gene.
synonym: "PKC1" RELATED Gene-based [UniProtKB:P05130]
synonym: "CG6622" RELATED Gene-based [UniProtKB:P05130]
synonym: "Pkc53E" RELATED Gene-based [UniProtKB:P05130]
synonym: "fly-PRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "dPKC53E(BR)" EXACT [UniProtKB:P05130]
synonym: "PKC (fruit fly)" RELATED [UniProtKB:P05130]
xref: UniProtKB:P05130
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template FlyBase:FBgn0003091 ! Pkc53E (fruit fly)

[Term]
id: PR:P05696-1
name: protein kinase C alpha type isoform 1 (rat)
def: "A protein kinase C alpha type isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPRKCA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05696-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038974 ! protein kinase C alpha type isoform 1

[Term]
id: PR:000048912
name: protein kinase C alpha type, initiator methionine removed phosphorylated 2 (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 497 and 638, and phosphoserine at position 657 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046." [PRO:DNx, Reactome:R-HSA-4332337, Reactome:R-HSA-4332340, Reactome:R-HSA-5223292]
comment: Category=organism-modification.
synonym: "hPRKCA/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055679, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672, Thr-497/Thr-638, MOD:00047|Ser-657, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4332337 "PR:000048912 located_in GO:0005829"
xref: Reactome:R-HSA-4332340 "PR:000048912 located_in GO:0005886"
xref: Reactome:R-HSA-5223292 "PR:000048912 located_in GO:0005654"
is_a: PR:P17252 ! protein kinase C alpha type (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P04409
name: protein kinase C alpha type (cow)
def: "A protein kinase C alpha type that is encoded in the genome of cow." [OMA:P04409, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "PRKCA" RELATED Gene-based [UniProtKB:P04409]
synonym: "cow-PRKCA" EXACT PRO-short-label [PRO:DNx]
synonym: "PKC-A (cow)" EXACT [UniProtKB:P04409]
synonym: "PKC-alpha (cow)" EXACT [UniProtKB:P04409]
xref: UniProtKB:P04409
intersection_of: only_in_taxon NCBITaxon:9913 ! Bos taurus
intersection_of: PR:000003058 ! protein kinase C alpha type
relationship: has_gene_template NCBIGene:282001 ! PRKCA (cow)

[Term]
id: PR:000048910
name: protein kinase C alpha type, initiator methionine removed form (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed. UniProtKB:P17252, 2-672." [PRO:DNx, Reactome:R-HSA-156469, Reactome:R-HSA-2648987, Reactome:R-HSA-450530, Reactome:R-HSA-58196]
comment: Category=organism-modification.
synonym: "PRO_0000055679" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hPRKCA/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-58196 "PR:000048910 located_in GO:0005829"
xref: Reactome:R-HSA-156469 "PR:000048910 located_in GO:0005886"
xref: Reactome:R-HSA-450530 "PR:000048910 located_in GO:0005654"
xref: Reactome:R-HSA-2648987 "PR:000048910 located_in GO:0097381"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P17252 ! protein kinase C alpha type (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048911
name: protein kinase C alpha type, initiator methionine removed phosphorylated 1 (human)
def: "A protein kinase C alpha type (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 497 of the amino acid sequence represented by UniProtKB:P17252. UniProtKB:P17252, 2-672, Thr-497, MOD:00047." [PRO:DNx, Reactome:R-HSA-5218731]
comment: Category=organism-modification.
synonym: "hPRKCA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000055679, Thr-497, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P17252, 2-672, Thr-497, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5218731 "PR:000048911 located_in GO:0005829"
is_a: PR:P17252 ! protein kinase C alpha type (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P90980-2
name: protein kinase C-like 2 isoform a (worm)
def: "A protein kinase C-like 2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P90980-2." [PRO:DNx, UniProtKB:P90980]
comment: Category=organism-sequence.
synonym: "PRKCA/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "protein kinase C-like 2 isoform PKC2A (worm)" EXACT [UniProtKB:P90980]
xref: UniProtKB:P90980-2
is_a: PR:P90980 ! protein kinase C-like 2 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:000038974
name: protein kinase C alpha type isoform 1
def: "A protein kinase C alpha type that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17252-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PRKCA/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003058 ! protein kinase C alpha type