[Term] id: PR:000003190 name: shc-transforming protein 1 isoform 2 phosphorylated 1 def: "An shc-transforming protein 1 isoform 2 phosphorylated form in which the phosphorylation occurs at Ser and Tyr residues by the action of activated TGF beta receptor type 1." [PID:SHC, PMID:17673906] comment: Category=modification. synonym: "SHC1/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003189 ! shc-transforming protein 1 isoform 2 phosphorylated form [Term] id: PR:P29353-2 name: SHC-transforming protein 1 isoform p52Shc (human) def: "An shc-transforming protein 1 isoform 2 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSHC1/iso:p52Shc" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29353-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003183 ! shc-transforming protein 1 isoform 2 [Term] id: PR:P29353-3 name: SHC-transforming protein 1 isoform p46Shc (human) def: "An shc-transforming protein 1 isoform 3 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSHC1/iso:p46Shc" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29353-3 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003184 ! shc-transforming protein 1 isoform 3 [Term] id: PR:P29353-1 name: SHC-transforming protein 1 isoform p66Shc (human) def: "An shc-transforming protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSHC1/iso:p66Shc" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-1433366 "PR:P29353-1 located_in GO:0005829" xref: Reactome:R-HSA-2404179 "PR:P29353-1 located_in GO:0005886" xref: UniProtKB:P29353-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003182 ! shc-transforming protein 1 isoform 1 [Term] id: PR:P29353-6 name: SHC-transforming protein 1 isoform h6 (human) def: "An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-6." [PRO:DNx, UniProtKB:P29353] comment: Category=organism-sequence. synonym: "hSHC1/iso:h6" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29353-6 is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P29353-7 name: SHC-transforming protein 1 isoform h7 (human) def: "An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-7." [PRO:DNx, UniProtKB:P29353] comment: Category=organism-sequence. synonym: "hSHC1/iso:h7" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29353-7 is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P98083 name: SHC-transforming protein 1 (mouse) def: "An shc-transforming protein 1 that is encoded in the genome of mouse." [OMA:P98083, PRO:DNx] comment: Category=organism-gene. synonym: "Shc" RELATED Gene-based [UniProtKB:P98083] synonym: "Shc1" RELATED Gene-based [UniProtKB:P98083] synonym: "ShcA" RELATED Gene-based [UniProtKB:P98083] synonym: "mSHC1" EXACT PRO-short-label [PRO:DNx] synonym: "SH2 domain protein C1 (mouse)" EXACT [UniProtKB:P98083] synonym: "SHC-transforming protein A (mouse)" EXACT [UniProtKB:P98083] synonym: "Src homology 2 domain-containing-transforming protein C1 (mouse)" EXACT [UniProtKB:P98083] xref: UniProtKB:P98083 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003178 ! shc-transforming protein 1 relationship: has_gene_template MGI:98296 ! Shc1 (mouse) [Term] id: PR:P29353 name: SHC-transforming protein 1 (human) def: "An shc-transforming protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29353] comment: Category=organism-gene. synonym: "SHC" RELATED Gene-based [UniProtKB:P29353] synonym: "SHC1" RELATED Gene-based [UniProtKB:P29353] synonym: "SHCA" RELATED Gene-based [UniProtKB:P29353] synonym: "hSHC1" EXACT PRO-short-label [PRO:DNx] synonym: "SH2 domain protein C1 (human)" EXACT [UniProtKB:P29353] synonym: "SHC-transforming protein 3 (human)" RELATED [UniProtKB:P29353] synonym: "SHC-transforming protein A (human)" EXACT [UniProtKB:P29353] synonym: "Src homology 2 domain-containing-transforming protein C1 (human)" EXACT [UniProtKB:P29353] xref: Reactome:R-HSA-74680 "PR:P29353 located_in GO:0005829" xref: UniProtKB:P29353 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003178 ! shc-transforming protein 1 relationship: has_gene_template HGNC:10840 ! SHC1 (human) [Term] id: PR:000003178 name: shc-transforming protein 1 def: "An shc-transforming protein that is a translation product of the human SHC1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "SHC" RELATED Gene-based [] synonym: "SHC1" EXACT PRO-short-label [PRO:DNx] synonym: "SHCA" RELATED Gene-based [] synonym: "SH2 domain protein C1" EXACT [] synonym: "SHC-transforming protein 3" RELATED [] synonym: "SHC-transforming protein A" RELATED [] synonym: "src homology 2 domain-containing-transforming protein C1" EXACT [] is_a: PR:000003177 ! shc-transforming protein [Term] id: PR:P98083-2 name: SHC-transforming protein 1 isoform p52Shc (mouse) def: "An shc-transforming protein 1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSHC1/iso:p52Shc" EXACT PRO-short-label [PRO:DNx] synonym: "SHC-transforming protein 1 isoform p52 (mouse)" EXACT [UniProtKB:P98083] xref: UniProtKB:P98083-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003183 ! shc-transforming protein 1 isoform 2 [Term] id: PR:P98083-3 name: SHC-transforming protein 1 isoform p47Shc (mouse) def: "An shc-transforming protein 1 isoform 3 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSHC1/iso:p47Shc" EXACT PRO-short-label [PRO:DNx] synonym: "SHC-transforming protein 1 isoform p47 (mouse)" EXACT [UniProtKB:P98083] xref: UniProtKB:P98083-3 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003184 ! shc-transforming protein 1 isoform 3 [Term] id: PR:P98083-1 name: SHC-transforming protein 1 isoform p66Shc (mouse) def: "An shc-transforming protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSHC1/iso:p66Shc" EXACT PRO-short-label [PRO:DNx] synonym: "SHC-transforming protein 1 isoform p66 (mouse)" EXACT [UniProtKB:P98083] xref: UniProtKB:P98083-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003182 ! shc-transforming protein 1 isoform 1 [Term] id: PR:P29353-5 name: SHC-transforming protein 1 isoform h5 (human) def: "An SHC-transforming protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29353-5." [PRO:DNx, UniProtKB:P29353] comment: Category=organism-sequence. synonym: "hSHC1/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29353-5 is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000003189 name: shc-transforming protein 1 isoform 2 phosphorylated form def: "An shc-transforming protein 1 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "SHC1/iso:2/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000003183 ! shc-transforming protein 1 isoform 2 [Term] id: PR:000003182 name: shc-transforming protein 1 isoform 1 def: "An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-1 or a 1:1 ortholog thereof." [PMID:11948181, PRO:CNA] comment: Category=sequence. synonym: "p66Shc" EXACT [] synonym: "SHC1 p66" EXACT [] synonym: "SHCA p66" EXACT [] synonym: "SHC1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003178 ! shc-transforming protein 1 [Term] id: PR:000003183 name: shc-transforming protein 1 isoform 2 def: "An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "p52Shc" EXACT [] synonym: "SHC1 p52" EXACT [] synonym: "SHCA p52" EXACT [] synonym: "SHC1/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003178 ! shc-transforming protein 1 [Term] id: PR:000003184 name: shc-transforming protein 1 isoform 3 def: "An shc-transforming protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P98083-3 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "SHC1 p47" EXACT [] synonym: "SHCA p47" EXACT [] synonym: "SHC1/iso:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003178 ! shc-transforming protein 1 [Term] id: PR:000003186 name: shc-transforming protein 1 isoform 1 phosphorylated form def: "An shc-transforming protein 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "SHC1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000003182 ! shc-transforming protein 1 isoform 1 [Term] id: PR:000003187 name: shc-transforming protein 1 isoform 1 phosphorylated 1 def: "An shc-transforming protein 1 isoform 1 phosphorylated form in which the phosphorylation occurs at Ser and Tyr residues by the action of activated TGF beta receptor type 1." [PID:SHC, PMID:17673906] comment: Category=modification. synonym: "SHC1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003186 ! shc-transforming protein 1 isoform 1 phosphorylated form [Term] id: PR:000049230 name: SHC-transforming protein 1 phosphorylated 1 (human) def: "An SHC-transforming protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 349 and 350 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-349/Tyr-350, MOD:00048." [PRO:DNx, Reactome:R-HSA-180276] comment: Category=organism-modification. synonym: "hSHC1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P29353, Tyr-349/Tyr-350, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-180276 "PR:000049230 located_in GO:0005829" is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049231 name: SHC-transforming protein 1 phosphorylated 2 (human) def: "An SHC-transforming protein 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 349, 350 and 427 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-349/Tyr-350/Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-912321] comment: Category=organism-modification. synonym: "hSHC1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P29353, Tyr-349/Tyr-350/Tyr-427, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-912321 "PR:000049231 located_in GO:0005829" xref: Reactome:R-HSA-2404176 "PR:000049231 located_in GO:0005829" is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049232 name: SHC-transforming protein 1 phosphorylated 3 (human) def: "An SHC-transforming protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-427 of the amino acid sequence represented by UniProtKB:P29353. UniProtKB:P29353, Tyr-427, MOD:00048." [PRO:DNx, Reactome:R-HSA-74684] comment: Category=organism-modification. synonym: "hSHC1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P29353, Tyr-427, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-74684 "PR:000049232 located_in GO:0005829" is_a: PR:P29353 ! SHC-transforming protein 1 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049233 name: SHC-transforming protein 1 phosphotyrosine form (human) def: "An SHC-transforming protein 1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P29353, MOD:00048." [PRO:DNx, Reactome:R-HSA-162568] comment: Category=organism-modification. synonym: "hSHC1/PhosTyr+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P29353, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-162568 "PR:000049233 located_in GO:0005829" intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine intersection_of: PR:P29353 ! SHC-transforming protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q5M824 name: SHC-transforming protein 1 (rat) def: "An shc-transforming protein 1 that is encoded in the genome of rat." [PANTHER:PTHR10337:SF2, PRO:DNx] comment: Category=organism-gene. synonym: "Shc1" RELATED Gene-based [UniProtKB:Q5M824] synonym: "rSHC1" EXACT PRO-short-label [PRO:DNx] synonym: "SH2 domain protein C1 (rat)" EXACT [UniProtKB:Q5M824] synonym: "Src homology 2 domain-containing-transforming protein C1 (rat)" EXACT [UniProtKB:Q5M824] xref: UniProtKB:Q5M824 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000003178 ! shc-transforming protein 1 relationship: has_gene_template RGD:620446 ! Shc1 (rat)