[Term]
id: PR:000003192
name: E3 ubiquitin-protein ligase Itchy
def: "A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human ITCH gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "AIP4" EXACT []
synonym: "ITCH" EXACT PRO-short-label [PRO:DNx]
synonym: "Itch" EXACT []
synonym: "NAPP1" EXACT []
synonym: "NFE2-associated polypeptide 1" EXACT []
synonym: "atrophin-1-interacting protein 4" EXACT []
synonym: "E3 ubiquitin-protein ligase itchy" EXACT []
synonym: "HECT-type E3 ubiquitin transferase Itchy homolog" EXACT []
is_a: PR:000000016 ! HECT domain-containing E3 ubiquitin-protein ligase with WW domains

[Term]
id: PR:Q96J02-2
name: E3 ubiquitin-protein ligase Itchy homolog isoform h2 (human)
def: "An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-2." [PRO:DNx, UniProtKB:Q96J02]
comment: Category=organism-sequence.
synonym: "hITCH/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96J02-2
is_a: PR:Q96J02 ! E3 ubiquitin-protein ligase Itchy homolog (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96J02-3
name: E3 ubiquitin-protein ligase Itchy homolog isoform h3 (human)
def: "An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-3." [PRO:DNx, UniProtKB:Q96J02]
comment: Category=organism-sequence.
synonym: "hITCH/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96J02-3
is_a: PR:Q96J02 ! E3 ubiquitin-protein ligase Itchy homolog (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96J02
name: E3 ubiquitin-protein ligase Itchy homolog (human)
def: "An E3 ubiquitin-protein ligase Itchy that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96J02]
comment: Category=organism-gene.
synonym: "ITCH" RELATED Gene-based [UniProtKB:Q96J02]
synonym: "hITCH" EXACT PRO-short-label [PRO:DNx]
synonym: "AIP4 (human)" EXACT [UniProtKB:Q96J02]
synonym: "Itch (human)" EXACT [UniProtKB:Q96J02]
synonym: "NAPP1 (human)" EXACT [UniProtKB:Q96J02]
synonym: "NFE2-associated polypeptide 1 (human)" EXACT [UniProtKB:Q96J02]
synonym: "atrophin-1-interacting protein 4 (human)" EXACT [UniProtKB:Q96J02]
synonym: "HECT-type E3 ubiquitin transferase Itchy homolog (human)" EXACT [UniProtKB:Q96J02]
xref: Reactome:R-HSA-975995 "PR:Q96J02 located_in GO:0005829"
xref: UniProtKB:Q96J02
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003192 ! E3 ubiquitin-protein ligase Itchy
relationship: has_gene_template HGNC:13890 ! ITCH (human)

[Term]
id: PR:Q96J02-1
name: E3 ubiquitin-protein ligase Itchy homolog isoform h1 (human)
def: "An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-1." [PRO:DNx, UniProtKB:Q96J02]
comment: Category=organism-sequence.
synonym: "hITCH/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96J02-1
is_a: PR:Q96J02 ! E3 ubiquitin-protein ligase Itchy homolog (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens