[Term]
id: PR:Q13233
name: mitogen-activated protein kinase kinase kinase 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13233]
comment: Category=organism-gene.
synonym: "MEKK" RELATED Gene-based [UniProtKB:Q13233]
synonym: "MEKK1" RELATED Gene-based [UniProtKB:Q13233]
synonym: "MAP3K1" RELATED Gene-based [UniProtKB:Q13233]
synonym: "MAPKKK1" RELATED Gene-based [UniProtKB:Q13233]
synonym: "hMAP3K1" EXACT PRO-short-label [PRO:DNx]
synonym: "MEKK 1 (human)" EXACT [UniProtKB:Q13233]
synonym: "MEK kinase 1 (human)" EXACT [UniProtKB:Q13233]
synonym: "MAPK/ERK kinase kinase 1 (human)" EXACT [UniProtKB:Q13233]
xref: DTO:03100283
xref: UniProtKB:Q13233
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003215 ! mitogen-activated protein kinase kinase kinase 1
relationship: has_gene_template HGNC:6848 ! MAP3K1 (human)

[Term]
id: PR:000048303
name: mitogen-activated protein kinase kinase kinase 1, initiator methionine removed phosphorylated 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 1400 and 1412 of the amino acid sequence represented by UniProtKB:Q13233. UniProtKB:Q13233, 2-1512, Thr-1400/Thr-1412, MOD:00047." [PRO:DNx, Reactome:R-HSA-2685607]
comment: Category=organism-modification.
synonym: "hMAP3K1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086240, Thr-1400/Thr-1412, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q13233, 2-1512, Thr-1400/Thr-1412, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2685607 "PR:000048303 located_in GO:0005829"
is_a: PR:Q13233 ! mitogen-activated protein kinase kinase kinase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000003215
name: mitogen-activated protein kinase kinase kinase 1
def: "A protein that is a translation product of the human MAP3K1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "MEKK" RELATED Gene-based []
synonym: "MEKK1" RELATED Gene-based []
synonym: "MAP3K1" EXACT PRO-short-label [PRO:DNx]
synonym: "MEKK 1" EXACT []
synonym: "MAPKKK1" RELATED Gene-based []
synonym: "MEK kinase 1" EXACT []
synonym: "MAPK/ERK kinase kinase 1" EXACT []
xref: IUPHARobj:2069
is_a: PR:000000001 ! protein

[Term]
id: PR:Q13233-1
name: mitogen-activated protein kinase kinase kinase 1 isoform 1 (human)
def: "A mitogen-activated protein kinase kinase kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMAP3K1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13233-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003216 ! mitogen-activated protein kinase kinase kinase 1 isoform 1

[Term]
id: PR:000048302
name: mitogen-activated protein kinase kinase kinase 1, initiator methionine removed form (human)
def: "A mitogen-activated protein kinase kinase kinase 1 (human) that has had the initiator methionine removed. UniProtKB:Q13233, 2-1512." [PRO:DNx, Reactome:R-HSA-166866]
comment: Category=organism-modification.
synonym: "PRO_0000086240" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAP3K1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13233, 2-1512" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-166866 "PR:000048302 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q13233 ! mitogen-activated protein kinase kinase kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens