[Term] id: PR:000045631 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-269 of the amino acid sequence represented by UniProtKB:P04049-1. Example: UniProtKB:P04049-1, Thr-269, MOD:00047." [PMID:7477354, iPTMnet:P04049] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:7477354). Status=unreviewed. synonym: "hRAF1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049-1, Thr-269, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q99N57 name: RAF proto-oncogene serine/threonine-protein kinase (mouse) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of mouse." [OMA:Q99N57, PRO:DNx] comment: Category=organism-gene. synonym: "Craf" RELATED Gene-based [UniProtKB:Q99N57] synonym: "Raf1" RELATED Gene-based [UniProtKB:Q99N57] synonym: "mRAF1" EXACT PRO-short-label [PRO:DNx] synonym: "cRaf (mouse)" EXACT [UniProtKB:Q99N57] synonym: "Raf-1 (mouse)" EXACT [UniProtKB:Q99N57] synonym: "proto-oncogene c-RAF (mouse)" EXACT [UniProtKB:Q99N57] xref: UniProtKB:Q99N57 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template MGI:97847 ! Raf1 (mouse) [Term] id: PR:000048998 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 4 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 29, 43, 259, 296, 301, 338, 494, 621 and 642, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-29/Ser-43/Ser-259/Ser-296/Ser-301/Ser-338/Ser-494/Ser-621/Ser-642, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5675193] comment: Category=organism-modification. synonym: "hRAF1/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-29/Ser-43/Ser-259/Ser-296/Ser-301/Ser-338/Ser-494/Ser-621/Ser-642, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5675193 "PR:000048998 located_in GO:0005886" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048999 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 5 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-338 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046." [PRO:DNx, Reactome:R-HSA-444236, Reactome:R-HSA-5624469] comment: Category=organism-modification. synonym: "hRAF1/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-338, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-444236 "PR:000048999 located_in GO:0005886" xref: Reactome:R-HSA-5624469 "PR:000048999 located_in GO:0005829" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000003250 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form in which the phosphorylation occurs at two consecutive Ser residues by PAK1. Example: UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046." [PMID:15849194, PRO:JAN] comment: Category=modification. synonym: "RAF1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003247 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P04049 name: RAF proto-oncogene serine/threonine-protein kinase (human) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PMID:20703093, PRO:KER] comment: Category=organism-gene. synonym: "RAF" RELATED Gene-based [UniProtKB:P04049] synonym: "RAF1" RELATED Gene-based [UniProtKB:P04049] synonym: "hRAF1" EXACT PRO-short-label [PRO:DNx] synonym: "cRaf (human)" EXACT [UniProtKB:P04049] synonym: "Raf-1 (human)" EXACT [UniProtKB:P04049] synonym: "proto-oncogene c-RAF (human)" EXACT [UniProtKB:P04049] xref: Reactome:R-HSA-167205 "PR:P04049 located_in GO:0005829" xref: DTO:03100445 xref: UniProtKB:P04049 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template HGNC:9829 ! RAF1 (human) [Term] id: PR:000026210 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 in human. UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046." [PMID:14688280, PRO:CNA] comment: Category=organism-modification. synonym: "hRAF1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026174 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000048997 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 3 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 259 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-259/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-109786] comment: Category=organism-modification. synonym: "hRAF1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-259/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-109786 "PR:000048997 located_in GO:0005829" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q54TH6 name: probable serine/threonine-protein kinase DDB_G0281745 (Dictyostelium discoideum) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of Dictyostelium discoideum." [PRO:CNA] comment: Category=organism-gene. synonym: "Dicty-RAF1" EXACT PRO-short-label [PRO:DNx] synonym: "DDB_G0281745" RELATED Gene-based [UniProtKB:Q54TH6] xref: UniProtKB:Q54TH6 intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template dictyBase:DDB_G0281745 ! DDB_G0281745 (Dictyostelium discoideum) [Term] id: PR:O94235 name: serine/threonine-protein kinase mph1 (Schizosaccharomyces pombe 972h-) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O94235, PRO:DNx] comment: Category=organism-gene. synonym: "mph1" RELATED Gene-based [UniProtKB:O94235] synonym: "SPBC106.01" RELATED Gene-based [UniProtKB:O94235] synonym: "SPBC243.01" RELATED Gene-based [UniProtKB:O94235] synonym: "SPBC1271.16c" RELATED Gene-based [UniProtKB:O94235] synonym: "Spom972h-RAF1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O94235 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template PomBase:SPBC106.01 ! mph1 (Schizosaccharomyces pombe) [Term] id: PR:000026174 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 3 def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that has been phosphorylated on the two 14-3-3 binding sites. Example: UniProtKB:P04049-1, Ser-259/Ser-621, MOD:00046." [PMID:14688280, PRO:CNA] comment: Category=modification. synonym: "RAF1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003245 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P11345 name: RAF proto-oncogene serine/threonine-protein kinase (rat) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of rat." [OMA:P11345, PANTHER:PTHR23257:SF42, PRO:DNx] comment: Category=organism-gene. synonym: "Raf" RELATED Gene-based [UniProtKB:P11345] synonym: "Raf1" RELATED Gene-based [UniProtKB:P11345] synonym: "rRAF1" EXACT PRO-short-label [PRO:DNx] synonym: "cRaf (rat)" EXACT [UniProtKB:P11345] synonym: "Raf-1 (rat)" EXACT [UniProtKB:P11345] synonym: "proto-oncogene c-RAF (rat)" EXACT [UniProtKB:P11345] xref: UniProtKB:P11345 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template RGD:3531 ! Raf1 (rat) [Term] id: PR:P05625 name: RAF proto-oncogene serine/threonine-protein kinase (chicken) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of chicken." [OMA:P05625, PANTHER:PTHR23257:SF42, PRO:DNx] comment: Category=organism-gene. synonym: "MIL" RELATED Gene-based [UniProtKB:P05625] synonym: "RAF1" RELATED Gene-based [UniProtKB:P05625] synonym: "chick-RAF1" EXACT PRO-short-label [PRO:DNx] synonym: "C-MIL (chicken)" EXACT [UniProtKB:P05625] synonym: "C-RAF (chicken)" EXACT [UniProtKB:P05625] synonym: "RAF-1 (chicken)" EXACT [UniProtKB:P05625] synonym: "MIL proto-oncogene serine/threonine-protein kinase (chicken)" EXACT [UniProtKB:P05625] xref: UniProtKB:P05625 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template NCBIGene:396245 ! RAF1 (chicken) [Term] id: PR:P05625-2 name: RAF proto-oncogene serine/threonine-protein kinase isoform 2 (chicken) def: "A RAF proto-oncogene serine/threonine-protein kinase (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05625-2." [PRO:DNx, UniProtKB:P05625] comment: Category=organism-sequence. synonym: "chick-RAF1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 1A (chicken)" EXACT [UniProtKB:P05625] xref: UniProtKB:P05625-2 is_a: PR:P05625 ! RAF proto-oncogene serine/threonine-protein kinase (chicken) relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus [Term] id: PR:P05625-1 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 (chicken) def: "A RAF proto-oncogene serine/threonine-protein kinase (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05625-1." [PRO:DNx, UniProtKB:P05625] comment: Category=organism-sequence. synonym: "chick-RAF1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 6C (chicken)" EXACT [UniProtKB:P05625] xref: UniProtKB:P05625-1 is_a: PR:P05625 ! RAF proto-oncogene serine/threonine-protein kinase (chicken) relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus [Term] id: PR:P04049-1 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hRAF1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 6C (human)" EXACT [UniProtKB:P04049] xref: UniProtKB:P04049-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003245 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 [Term] id: PR:P04049-2 name: RAF proto-oncogene serine/threonine-protein kinase isoform 2 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 2 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hRAF1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 1A (human)" EXACT [UniProtKB:P04049] xref: UniProtKB:P04049-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003248 ! RAF proto-oncogene serine/threonine-protein kinase isoform 2 [Term] id: PR:000003247 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "RAF1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000003245 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 [Term] id: PR:000003245 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 def: "A RAF proto-oncogene serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04049-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "RAF1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "RAF-1 isoform 6C" RELATED [] is_a: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase [Term] id: PR:000003244 name: RAF proto-oncogene serine/threonine-protein kinase def: "A protein that is a translation product of the human RAF1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "RAF" RELATED Gene-based [] synonym: "RAF1" EXACT PRO-short-label [PRO:DNx] synonym: "cRaf" EXACT [] synonym: "Raf-1" EXACT [] synonym: "proto-oncogene c-RAF" EXACT [] xref: IUPHARobj:2184 is_a: PR:000000001 ! protein [Term] id: PR:000046209 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 1 (mouse) def: "A RAF proto-oncogene serine/threonine-protein kinase (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-621 of the amino acid sequence represented by UniProtKB:Q99N57-1. Example: UniProtKB:Q99N57-1, Ser-621, MOD:00046." [PMID:18922468, iPTMnet:Q99N57] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18922468). Status=unreviewed. synonym: "mRAF1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q99N57-1, Ser-621, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q99N57 ! RAF proto-oncogene serine/threonine-protein kinase (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000003249 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 1 def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form in which the phosphorylation occurs at two consecutive Tyr residues by active Src kinases. Example: UniProtKB:P04049-1, Tyr-340/Tyr-341, MOD:00048." [PMID:7692235] comment: Category=modification. synonym: "RAF-1 active form" EXACT [] synonym: "RAF1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003247 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated form relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:000003248 name: RAF proto-oncogene serine/threonine-protein kinase isoform 2 def: "A RAF proto-oncogene serine/threonine-protein kinase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04049-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "RAF1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "RAF-1 isoform 1A" EXACT [] is_a: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase [Term] id: PR:000036643 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 in human. UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046." [PMID:15849194, PRO:JAN] comment: Category=organism-modification. synonym: "hRAF1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049-1, Ser-338/Ser-339, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003250 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P06784 name: serine/threonine-protein kinase STE7 (yeast) def: "A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of yeast." [OMA:P06784, PRO:DNx] comment: Category=organism-gene. synonym: "STE7" RELATED Gene-based [UniProtKB:P06784] synonym: "D1525" RELATED Gene-based [UniProtKB:P06784] synonym: "ySTE7" EXACT PRO-short-label [PRO:DAN] synonym: "YDL159W" RELATED Gene-based [UniProtKB:P06784] xref: UniProtKB:P06784 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000003244 ! RAF proto-oncogene serine/threonine-protein kinase relationship: has_gene_template SGD:S000002318 ! STE7 (yeast) [Term] id: PR:Q99N57-2 name: RAF proto-oncogene serine/threonine-protein kinase isoform 2 (mouse) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 2 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mRAF1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 1A (mouse)" EXACT [UniProtKB:Q99N57] xref: UniProtKB:Q99N57-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003248 ! RAF proto-oncogene serine/threonine-protein kinase isoform 2 [Term] id: PR:Q99N57-1 name: RAF proto-oncogene serine/threonine-protein kinase isoform 1 (mouse) def: "A RAF proto-oncogene serine/threonine-protein kinase isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mRAF1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "RAF proto-oncogene serine/threonine-protein kinase isoform 6C (mouse)" EXACT [UniProtKB:Q99N57] xref: UniProtKB:Q99N57-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003245 ! RAF proto-oncogene serine/threonine-protein kinase isoform 1 [Term] id: PR:000049003 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 9 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Tyr-341, phosphothreonine at position 491, and phosphoserine at positions 494 and 621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Tyr-341, MOD:00048|Thr-491, MOD:00047|Ser-494/Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-5675420] comment: Category=organism-modification. synonym: "hRAF1/Phos:9" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Tyr-341, MOD:00048|Thr-491, MOD:00047|Ser-494/Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5675420 "PR:000049003 located_in GO:0005886" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049002 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 8 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-621 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-206028, Reactome:R-HSA-206222] comment: Category=organism-modification. synonym: "hRAF1/Phos:8" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-206028 "PR:000049002 located_in GO:0005829" xref: Reactome:R-HSA-206222 "PR:000049002 located_in GO:0005886" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049001 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 7 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been post-translationally modified to include phosphoserine at positions 338, 494 and 621, phosphotyrosine at position 341, and phosphothreonine at position 491 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-5672664, Reactome:R-HSA-5672665] comment: Category=organism-modification. synonym: "hRAF1/Phos:7" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5672664 "PR:000049001 located_in GO:0005829" xref: Reactome:R-HSA-5672665 "PR:000049001 located_in GO:0005886" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049000 name: RAF proto-oncogene serine/threonine-protein kinase phosphorylated 6 (human) def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-338, and phosphotyrosine at positions 340 and 341 of the amino acid sequence represented by UniProtKB:P04049. UniProtKB:P04049, Ser-338, MOD:00046|Tyr-340/Tyr-341, MOD:00048." [PRO:DNx, Reactome:R-HSA-5624465] comment: Category=organism-modification. synonym: "hRAF1/Phos:6" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04049, Ser-338, MOD:00046|Tyr-340/Tyr-341, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5624465 "PR:000049000 located_in GO:0005829" is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens