[Term] id: PR:000021979 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 def: "A dual specificity mitogen-activated protein kinase kinase 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52564-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "MAP2K6/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000003282 ! dual specificity mitogen-activated protein kinase kinase 6 [Term] id: PR:000003282 name: dual specificity mitogen-activated protein kinase kinase 6 def: "A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K6 gene or a 1:1 ortholog thereof." [TLR:AMM] comment: Category=gene. Requested by=TLR. synonym: "MEK6" RELATED Gene-based [] synonym: "MKK6" RELATED Gene-based [] synonym: "SKK3" RELATED Gene-based [] synonym: "MEK 6" EXACT [] synonym: "MAP2K6" EXACT PRO-short-label [PRO:DNx] synonym: "PRKMK6" RELATED Gene-based [] synonym: "SAPKK3" EXACT [] synonym: "MAPKK 6" EXACT [] synonym: "MAPK/ERK kinase 6" EXACT [] synonym: "MAP kinase kinase 6" EXACT [] xref: IUPHARobj:2067 is_a: PR:000021990 ! dual specificity mitogen-activated protein kinase kinase 3/6 [Term] id: PR:000021980 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 unmodified form def: "A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA] comment: Category=modification. synonym: "MAP2K6/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part PR:000021935 ! immature protein part intersection_of: PR:000021979 ! dual specificity mitogen-activated protein kinase kinase 6 isoform 1 intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000021981 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated 1 def: "A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form in which the phosphorylation occurs in the activation loop by ubiquitinated TAK1. Example: UniProtKB:P52564-1, Ser-207, MOD:00046|Thr-211, MOD:00047." [PMID:11460167, TLR:AMM] comment: Category=modification. Requested by=TLR. synonym: "MKK6 active" EXACT [] synonym: "MAP2K6/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000021992 ! dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000045822 name: dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 1 (human) def: "A dual specificity mitogen-activated protein kinase kinase 6 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-219 of the amino acid sequence represented by UniProtKB:P52564-1. Example: UniProtKB:P52564-1, Tyr-219, MOD:00048." [PMID:17854274, iPTMnet:P52564] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17854274). Status=unreviewed. synonym: "hMAP2K6/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P52564-1, Tyr-219, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P52564 ! dual specificity mitogen-activated protein kinase kinase 6 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P52564-1 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (human) def: "A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hMAP2K6/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "dual specificity mitogen-activated protein kinase kinase 6 isoform MKK6b (human)" EXACT [UniProtKB:P52564] xref: Reactome:R-HSA-5211390 "PR:P52564-1 located_in GO:0005829" xref: UniProtKB:P52564-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000021979 ! dual specificity mitogen-activated protein kinase kinase 6 isoform 1 [Term] id: PR:P52564-2 name: dual specificity mitogen-activated protein kinase kinase 6 isoform h2 (human) def: "A dual specificity mitogen-activated protein kinase kinase 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P52564-2." [PRO:DNx, UniProtKB:P52564] comment: Category=organism-sequence. synonym: "hMAP2K6/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "dual specificity mitogen-activated protein kinase kinase 6 isoform MKK6 (human)" EXACT [UniProtKB:P52564] xref: UniProtKB:P52564-2 is_a: PR:P52564 ! dual specificity mitogen-activated protein kinase kinase 6 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048299 name: dual specificity mitogen-activated protein kinase kinase 6 phosphorylated 2 (human) def: "A dual specificity mitogen-activated protein kinase kinase 6 (human) that has been phosphorylated on the residue at the position equivalent to Ser-207, and phosphothreonine at position 211 of the amino acid sequence represented by UniProtKB:P52564. UniProtKB:P52564, Ser-207, MOD:00046|Thr-211, MOD:00047." [PRO:DNx, Reactome:R-HSA-206255, Reactome:R-HSA-450258] comment: Category=organism-modification. synonym: "hMAP2K6/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P52564, Ser-207, MOD:00046|Thr-211, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-206255 "PR:000048299 located_in GO:0005829" xref: Reactome:R-HSA-450258 "PR:000048299 located_in GO:0005654" is_a: PR:P52564 ! dual specificity mitogen-activated protein kinase kinase 6 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9DGE0 name: dual specificity mitogen-activated protein kinase kinase 6 (zebrafish) def: "A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of zebrafish." [OMA:Q9DGE0, PANTHER:PTHR24361:SF37, PRO:DNx] comment: Category=organism-gene. synonym: "zMKK3" EXACT [UniProtKB:Q9DGE0] synonym: "map2k3" RELATED Gene-based [UniProtKB:Q9DGE0] synonym: "map2k6" RELATED Gene-based [UniProtKB:Q9DGE0] synonym: "z-MAP2K6" EXACT PRO-short-label [PRO:DNx] synonym: "MAPKK 6 (zebrafish)" EXACT [UniProtKB:Q9DGE0] synonym: "MAP kinase kinase 6 (zebrafish)" EXACT [UniProtKB:Q9DGE0] synonym: "mitogen-activated protein kinase kinase 3 (zebrafish)" EXACT [UniProtKB:Q9DGE0] xref: UniProtKB:Q9DGE0 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000003282 ! dual specificity mitogen-activated protein kinase kinase 6 relationship: has_gene_template ZFIN:ZDB-GENE-010202-3 ! map2k6 (zebrafish) [Term] id: PR:P70236-1 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 (mouse) def: "A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mMAP2K6/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70236-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000021979 ! dual specificity mitogen-activated protein kinase kinase 6 isoform 1 [Term] id: PR:P52564 name: dual specificity mitogen-activated protein kinase kinase 6 (human) def: "A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of human." [TLR:AMM, UniProtKB:P52564] comment: Category=organism-gene. synonym: "MEK6" RELATED Gene-based [UniProtKB:P52564] synonym: "MKK6" RELATED Gene-based [UniProtKB:P52564] synonym: "SKK3" RELATED Gene-based [UniProtKB:P52564] synonym: "MAP2K6" RELATED Gene-based [UniProtKB:P52564] synonym: "PRKMK6" RELATED Gene-based [UniProtKB:P52564] synonym: "hMAP2K6" EXACT PRO-short-label [PRO:DNx] synonym: "MEK 6 (human)" EXACT [UniProtKB:P52564] synonym: "SAPKK3 (human)" EXACT [UniProtKB:P52564] synonym: "MAPKK 6 (human)" EXACT [UniProtKB:P52564] synonym: "SAPKK-3 (human)" EXACT [UniProtKB:P52564] synonym: "SAPK kinase 3 (human)" EXACT [UniProtKB:P52564] synonym: "MAPK/ERK kinase 6 (human)" EXACT [UniProtKB:P52564] synonym: "MAP kinase kinase 6 (human)" EXACT [UniProtKB:P52564] synonym: "stress-activated protein kinase kinase 3 (human)" EXACT [UniProtKB:P52564] xref: Reactome:R-HSA-167998 "PR:P52564 located_in GO:0005829" xref: DTO:03100339 xref: UniProtKB:P52564 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003282 ! dual specificity mitogen-activated protein kinase kinase 6 relationship: has_gene_template HGNC:6846 ! MAP2K6 (human) [Term] id: PR:P70236 name: dual specificity mitogen-activated protein kinase kinase 6 (mouse) def: "A dual specificity mitogen-activated protein kinase kinase 6 that is encoded in the genome of mouse." [OMA:P70236, PRO:DNx] comment: Category=organism-gene. synonym: "Map2k6" RELATED Gene-based [UniProtKB:P70236] synonym: "Prkmk6" RELATED Gene-based [UniProtKB:P70236] synonym: "Sapkk3" RELATED Gene-based [UniProtKB:P70236] synonym: "mMAP2K6" EXACT PRO-short-label [PRO:DNx] synonym: "MEK 6 (mouse)" EXACT [UniProtKB:P70236] synonym: "SAPKK3 (mouse)" EXACT [UniProtKB:P70236] synonym: "MAPKK 6 (mouse)" EXACT [UniProtKB:P70236] synonym: "MAPK/ERK kinase 6 (mouse)" EXACT [UniProtKB:P70236] synonym: "MAP kinase kinase 6 (mouse)" EXACT [UniProtKB:P70236] xref: UniProtKB:P70236 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000003282 ! dual specificity mitogen-activated protein kinase kinase 6 relationship: has_gene_template MGI:1346870 ! Map2k6 (mouse) [Term] id: PR:000021992 name: dual specificity mitogen-activated protein kinase kinase 6 isoform 1 phosphorylated form def: "A dual specificity mitogen-activated protein kinase kinase 6 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "MAP2K6/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000021979 ! dual specificity mitogen-activated protein kinase kinase 6 isoform 1