[Term] id: PR:000003505 name: leukocyte granule-associated proteinase def: "A trypsin that is a serine protease of the granules from mast cells, cytotoxic T lymphocytes and/or natural killer cells. Leukocyte granule-associated proteinase is a component of the immune system that protect higher organisms against viral infection and cellular transformation. Members of this class have features that are strongly conserved including: consensus sequences at their N-termini and around the three catalytic residues, activation from zymogenic forms, and conserved disulphide bridges." [PMID:11790262, PMID:7952649, PMID:8929545] comment: Category=family. is_a: PR:000027795 ! trypsin