[Term]
id: PR:000046279
name: beta-adrenergic receptor kinase 1 phosphorylated 2 (human)
def: "A beta-adrenergic receptor kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P25098. UniProtKB:P25098, Ser-29, MOD:00046." [PRO:DNx, Reactome:R-HSA-111969]
comment: Category=organism-modification.
synonym: "hGRK2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25098, Ser-29, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-111969 "PR:000046279 located_in GO:0005829"
xref: Reactome:R-HSA-9645318 "PR:000046279 located_in GO:0005829"
is_a: PR:P25098 ! beta-adrenergic receptor kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000018915
name: beta-adrenergic receptor kinase 1, initiator methionine removed form
def: "A beta-adrenergic receptor kinase 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "GRK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003791 ! beta-adrenergic receptor kinase 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045725
name: beta-adrenergic receptor kinase 1 phosphorylated 1 (human)
def: "A beta-adrenergic receptor kinase 1 (human) that has been phosphorylated at Ser-685. UniProtKB:P25098, Ser-685, MOD:00046." [PMID:11278469, iPTMnet:P25098]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11278469). Status=unreviewed.
synonym: "hGRK2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25098, Ser-685, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P25098 ! beta-adrenergic receptor kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003791
name: beta-adrenergic receptor kinase 1
def: "A protein that is a translation product of the human GRK2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BARK" RELATED Gene-based []
synonym: "GRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "BARK1" RELATED Gene-based []
synonym: "ADRBK1" RELATED Gene-based []
synonym: "beta-ARK-1" EXACT []
synonym: "G-protein coupled receptor kinase 2" EXACT []
synonym: "G-protein-coupled receptor kinase 2" EXACT []
xref: IUPHARobj:1466
is_a: PR:000000001 ! protein

[Term]
id: PR:P25098-1
name: beta-adrenergic receptor kinase 1 isoform 1 (human)
def: "A beta-adrenergic receptor kinase 1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hGRK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25098-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039130 ! beta-adrenergic receptor kinase 1 isoform 1

[Term]
id: PR:Q99MK8
name: beta-adrenergic receptor kinase 1 (mouse)
def: "A beta-adrenergic receptor kinase 1 that is encoded in the genome of mouse." [OMA:Q99MK8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Grk2" RELATED Gene-based [UniProtKB:Q99MK8]
synonym: "mGRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "Adrbk1" RELATED Gene-based [UniProtKB:Q99MK8]
synonym: "beta-ARK-1 (mouse)" EXACT [UniProtKB:Q99MK8]
synonym: "G-protein-coupled receptor kinase 2 (mouse)" EXACT [UniProtKB:Q99MK8]
xref: UniProtKB:Q99MK8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003791 ! beta-adrenergic receptor kinase 1
relationship: has_gene_template MGI:87940 ! Grk2 (mouse)

[Term]
id: PR:P26817
name: beta-adrenergic receptor kinase 1 (rat)
def: "A beta-adrenergic receptor kinase 1 that is encoded in the genome of rat." [OMA:P26817, PANTHER:PTHR24355:SF5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Grk2" RELATED Gene-based [UniProtKB:P26817]
synonym: "rGRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "Adrbk1" RELATED Gene-based [UniProtKB:P26817]
synonym: "beta-ARK-1 (rat)" EXACT [UniProtKB:P26817]
synonym: "G-protein-coupled receptor kinase 2 (rat)" EXACT [UniProtKB:P26817]
xref: UniProtKB:P26817
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003791 ! beta-adrenergic receptor kinase 1
relationship: has_gene_template RGD:2062 ! Grk2 (rat)

[Term]
id: PR:P26817-1
name: beta-adrenergic receptor kinase 1 isoform 1 (rat)
def: "A beta-adrenergic receptor kinase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rGRK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P26817-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000039130 ! beta-adrenergic receptor kinase 1 isoform 1

[Term]
id: PR:000028400
name: beta-adrenergic receptor kinase 1, initiator methionine removed form (human)
def: "A beta-adrenergic receptor kinase 1, initiator methionine removed form in human." [PRO:DNx]
comment: Category=organism-modification.
synonym: "hGRK2/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018915 ! beta-adrenergic receptor kinase 1, initiator methionine removed form

[Term]
id: PR:000039130
name: beta-adrenergic receptor kinase 1 isoform 1
def: "A beta-adrenergic receptor kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25098-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "GRK2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003791 ! beta-adrenergic receptor kinase 1

[Term]
id: PR:P25098
name: beta-adrenergic receptor kinase 1 (human)
def: "A beta-adrenergic receptor kinase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P25098]
comment: Category=organism-gene.
synonym: "BARK" RELATED Gene-based [UniProtKB:P25098]
synonym: "GRK2" RELATED Gene-based [UniProtKB:P25098]
synonym: "BARK1" RELATED Gene-based [UniProtKB:P25098]
synonym: "hGRK2" EXACT PRO-short-label [PRO:DNx]
synonym: "ADRBK1" RELATED Gene-based [UniProtKB:P25098]
synonym: "beta-ARK-1 (human)" EXACT [UniProtKB:P25098]
synonym: "G-protein coupled receptor kinase 2 (human)" EXACT [UniProtKB:P25098]
xref: Reactome:R-HSA-50270 "PR:P25098 located_in GO:0005886"
xref: Reactome:R-HSA-5632504 "PR:P25098 located_in GO:0005929"
xref: DTO:03100031
xref: UniProtKB:P25098
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003791 ! beta-adrenergic receptor kinase 1
relationship: has_gene_template HGNC:289 ! GRK2 (human)

[Term]
id: PR:Q99MK8-1
name: beta-adrenergic receptor kinase 1 isoform 1 (mouse)
def: "A beta-adrenergic receptor kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mGRK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99MK8-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039130 ! beta-adrenergic receptor kinase 1 isoform 1