[Term]
id: PR:000004515
name: aurora kinase A
def: "An aurora kinase that is a translation product of the human AURKA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AIK" RELATED Gene-based []
synonym: "ARK1" RELATED Gene-based []
synonym: "AURA" RELATED Gene-based []
synonym: "Ayk1" RELATED []
synonym: "BTAK" RELATED Gene-based []
synonym: "Iak1" RELATED []
synonym: "STK6" RELATED Gene-based []
synonym: "AIRK1" RELATED Gene-based []
synonym: "ARK-1" EXACT []
synonym: "AURKA" EXACT PRO-short-label [PRO:DNx]
synonym: "STK15" RELATED Gene-based []
synonym: "aurora 2" EXACT []
synonym: "aurora family kinase 1" EXACT []
synonym: "aurora-related kinase 1" EXACT []
synonym: "aurora/IPL1-related kinase 1" EXACT []
synonym: "breast tumor-amplified kinase" EXACT []
synonym: "ipl1- and aurora-related kinase 1" EXACT []
synonym: "serine/threonine-protein kinase 6" EXACT []
synonym: "serine/threonine-protein kinase 15" EXACT []
synonym: "serine/threonine-protein kinase Ayk1" EXACT []
synonym: "serine/threonine-protein kinase aurora-A" EXACT []
xref: IUPHARobj:1936
is_a: PR:000035365 ! aurora kinase

[Term]
id: PR:000045573
name: aurora kinase A phosphorylated 1 (human)
def: "An aurora kinase A (human) that has been phosphorylated at Thr-288. UniProtKB:O14965, Thr-288, MOD:00047." [PMID:11039908, iPTMnet:O14965]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11039908). Status=unreviewed.
synonym: "hAURKA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14965, Thr-288, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2574832 "PR:000045573 located_in GO:0005829"
xref: Reactome:R-HSA-6805089 "PR:000045573 located_in GO:0005654"
is_a: PR:O14965 ! aurora kinase A (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046439
name: aurora kinase A sumoylated 1 (human)
def: "An aurora kinase A (human) that has been post-translationally modified to include sumoylated lysine at position 258 of the amino acid sequence represented by UniProtKB:O14965. UniProtKB:O14965, Lys-258, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655367]
comment: Category=organism-modification.
synonym: "hAURKA/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14965, Lys-258, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4655367 "PR:000046439 located_in GO:0005829"
is_a: PR:O14965 ! aurora kinase A (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14965
name: aurora kinase A (human)
def: "An aurora kinase A that is encoded in the genome of human." [PRO:KER]
comment: Category=organism-gene.
synonym: "AIK" RELATED Gene-based [UniProtKB:O14965]
synonym: "ARK1" RELATED Gene-based [UniProtKB:O14965]
synonym: "AURA" RELATED Gene-based [UniProtKB:O14965]
synonym: "AYK1" RELATED Gene-based [UniProtKB:O14965]
synonym: "BTAK" RELATED Gene-based [UniProtKB:O14965]
synonym: "IAK1" RELATED Gene-based [UniProtKB:O14965]
synonym: "STK6" RELATED Gene-based [UniProtKB:O14965]
synonym: "AIRK1" RELATED Gene-based [UniProtKB:O14965]
synonym: "AURKA" RELATED Gene-based [UniProtKB:O14965]
synonym: "STK15" RELATED Gene-based [UniProtKB:O14965]
synonym: "hAURKA" EXACT PRO-short-label [PRO:DNx]
synonym: "ARK-1 (human)" EXACT [UniProtKB:O14965]
synonym: "aurora 2 (human)" EXACT [UniProtKB:O14965]
synonym: "aurora-related kinase 1 (human)" EXACT [UniProtKB:O14965]
synonym: "aurora/IPL1-related kinase 1 (human)" EXACT [UniProtKB:O14965]
synonym: "breast tumor-amplified kinase (human)" EXACT [UniProtKB:O14965]
synonym: "Ipl1- and aurora-related kinase 1 (human)" EXACT [UniProtKB:O14965]
synonym: "serine/threonine-protein kinase 6 (human)" EXACT [UniProtKB:O14965]
synonym: "serine/threonine-protein kinase 15 (human)" EXACT [UniProtKB:O14965]
synonym: "serine/threonine-protein kinase Ayk1 (human)" EXACT [UniProtKB:O14965]
synonym: "serine/threonine-protein kinase aurora-A (human)" EXACT [UniProtKB:O14965]
xref: Reactome:R-HSA-174254 "PR:O14965 located_in GO:0005829"
xref: Reactome:R-HSA-4655443 "PR:O14965 located_in GO:0005654"
xref: DTO:03100035
xref: UniProtKB:O14965
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004515 ! aurora kinase A
relationship: has_gene_template HGNC:11393 ! AURKA (human)