[Term]
id: PR:O15169
name: Axin-1 (human)
def: "An Axin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15169]
comment: Category=organism-gene.
synonym: "AXIN" RELATED Gene-based [UniProtKB:O15169]
synonym: "AXIN1" RELATED Gene-based [UniProtKB:O15169]
synonym: "hAxin" EXACT [UniProtKB:O15169]
synonym: "hAXIN1" EXACT PRO-short-label [PRO:DNx]
synonym: "axis inhibition protein 1 (human)" EXACT [UniProtKB:O15169]
xref: Reactome:R-HSA-195249 "PR:O15169 located_in GO:0005829"
xref: UniProtKB:O15169
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004526 ! Axin-1
relationship: has_gene_template HGNC:903 ! AXIN1 (human)

[Term]
id: PR:O15169-2
name: Axin-1 isoform 2 (human)
def: "An Axin-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hAXIN1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15169-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025826 ! Axin-1 isoform 2

[Term]
id: PR:000004526
name: Axin-1
def: "An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Fu" RELATED Gene-based []
synonym: "AXIN" RELATED Gene-based []
synonym: "AXIN1" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Fused" EXACT []
synonym: "axis inhibition protein 1" EXACT []
is_a: PR:000025824 ! Axin

[Term]
id: PR:O15169-1
name: Axin-1 isoform 1 (human)
def: "An Axin-1 isoform 1 that is encoded in the genome of human." [PMID:9230313, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hAXIN1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15169-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025825 ! Axin-1 isoform 1

[Term]
id: PR:000046444
name: Axin-1 phosphorylated 1 (human)
def: "An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046." [PRO:DAN, Reactome:R-HSA-206040]
comment: Category=organism-modification. Note: The modified sites indicated here (Thr-481/Ser-486/Ser-493) are referred to as Thr-609/Ser-614/Ser-621 in the literature using the mouse sequence. [PRO:DAN, PMID:10581160]
synonym: "hAXIN1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-206040 "PR:000046444 located_in GO:0005829"
is_a: PR:O15169 ! Axin-1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046445
name: Axin-1 ubiquitinated 1 (human)
def: "An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148." [PRO:DAN, Reactome:R-HSA-4641133]
comment: Category=organism-modification. Note: The modified site indicated here (Lys-501) is referred to as Lys-505 in the literature using the mouse Axin1 sequence. [PRO:DAN, PMID:20858899]
synonym: "hAXIN1/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15169, Lys-501, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641133 "PR:000046445 located_in GO:0005829"
is_a: PR:O15169 ! Axin-1 (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046442
name: Axin-1 ADP-ribosylated form (human)
def: "An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752." [PRO:DNx, Reactome:R-HSA-3640841]
comment: Category=organism-modification.
synonym: "hAXIN1/ADPribRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15169, MOD:00752" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3640841 "PR:000046442 located_in GO:0005829"
intersection_of: has_part MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
intersection_of: PR:O15169 ! Axin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046443
name: Axin-1 ADP-ribosylated and ubiquitinated form (human)
def: "An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148." [PRO:DNx, Reactome:R-HSA-3640864]
comment: Category=organism-modification.
synonym: "hAXIN1/ADPribUbiq+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15169, MOD:00752|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3640864 "PR:000046443 located_in GO:0005829"
intersection_of: has_part MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:O15169 ! Axin-1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens