[Term] id: PR:O35625 name: Axin-1 (mouse) def: "An Axin-1 that is encoded in the genome of mouse." [OMA:O35625, PRO:DNx] comment: Category=organism-gene. synonym: "Fu" RELATED Gene-based [UniProtKB:O35625] synonym: "Axin" RELATED Gene-based [UniProtKB:O35625] synonym: "Axin1" RELATED Gene-based [UniProtKB:O35625] synonym: "mAXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "protein Fused (mouse)" EXACT [UniProtKB:O35625] synonym: "axis inhibition protein 1 (mouse)" EXACT [UniProtKB:O35625] xref: UniProtKB:O35625 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000004526 ! Axin-1 relationship: has_gene_template MGI:1096327 ! Axin1 (mouse) [Term] id: PR:P57094 name: Axin-1 (zebrafish) def: "An Axin-1 that is encoded in the genome of zebrafish." [PANTHER:PTHR10845:SF11, PRO:DNx] comment: Category=organism-gene. synonym: "axin" RELATED Gene-based [UniProtKB:P57094] synonym: "axin1" RELATED Gene-based [UniProtKB:P57094] synonym: "z-AXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "axis inhibition protein 1 (zebrafish)" EXACT [UniProtKB:P57094] xref: UniProtKB:P57094 intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio intersection_of: PR:000004526 ! Axin-1 relationship: has_gene_template ZFIN:ZDB-GENE-000403-1 ! axin1 (zebrafish) [Term] id: PR:Q9V407 name: Axin (fruit fly) def: "An Axin-1 that is encoded in the genome of fruit fly." [OMA:Q9V407, PRO:DNx] comment: Category=organism-gene. synonym: "Axn" RELATED Gene-based [UniProtKB:Q9V407] synonym: "dAxin" EXACT [UniProtKB:Q9V407] synonym: "CG7926" RELATED Gene-based [UniProtKB:Q9V407] synonym: "d-Axin" EXACT [UniProtKB:Q9V407] synonym: "fly-AXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "axis inhibition protein (fruit fly)" EXACT [UniProtKB:Q9V407] xref: UniProtKB:Q9V407 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000004526 ! Axin-1 relationship: has_gene_template FlyBase:FBgn0026597 ! Axn (fruit fly) [Term] id: PR:O15169 name: Axin-1 (human) def: "An Axin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15169] comment: Category=organism-gene. synonym: "AXIN" RELATED Gene-based [UniProtKB:O15169] synonym: "AXIN1" RELATED Gene-based [UniProtKB:O15169] synonym: "hAxin" EXACT [UniProtKB:O15169] synonym: "hAXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "axis inhibition protein 1 (human)" EXACT [UniProtKB:O15169] xref: Reactome:R-HSA-195249 "PR:O15169 located_in GO:0005829" xref: UniProtKB:O15169 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004526 ! Axin-1 relationship: has_gene_template HGNC:903 ! AXIN1 (human) [Term] id: PR:000025826 name: Axin-1 isoform 2 def: "An Axin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35625-2 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "AXIN" RELATED [] synonym: "AXIN1/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004526 ! Axin-1 [Term] id: PR:000025825 name: Axin-1 isoform 1 def: "An Axin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35625-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "AXIN1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000004526 ! Axin-1 [Term] id: PR:O15169-2 name: Axin-1 isoform 2 (human) def: "An Axin-1 isoform 2 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hAXIN1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O15169-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000025826 ! Axin-1 isoform 2 [Term] id: PR:O70239-1 name: Axin-1 isoform 2 (rat) def: "An Axin-1 isoform 2 that is encoded in the genome of rat." [PMID:9482734, PRO:CNA] comment: Category=organism-sequence. synonym: "rAXIN1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O70239-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000025826 ! Axin-1 isoform 2 [Term] id: PR:O35625-2 name: Axin-1 isoform 2 (mouse) def: "An Axin-1 isoform 2 that is encoded in the genome of mouse." [PMID:9230313, PRO:HJD] comment: Category=organism-sequence. synonym: "mAXIN1/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35625-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000025826 ! Axin-1 isoform 2 [Term] id: PR:O70239 name: Axin-1 (rat) def: "An Axin-1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-gene. synonym: "Axin" RELATED Gene-based [UniProtKB:O70239] synonym: "Axin1" RELATED Gene-based [UniProtKB:O70239] synonym: "rAxin" EXACT [UniProtKB:O70239] synonym: "rAXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "axis inhibition protein 1 (rat)" EXACT [UniProtKB:O70239] xref: UniProtKB:O70239 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000004526 ! Axin-1 relationship: has_gene_template RGD:620859 ! Axin1 (rat) [Term] id: PR:000004526 name: Axin-1 def: "An Axin that is a translation product of the human AXIN1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "Fu" RELATED Gene-based [] synonym: "AXIN" RELATED Gene-based [] synonym: "AXIN1" EXACT PRO-short-label [PRO:DNx] synonym: "protein Fused" EXACT [] synonym: "axis inhibition protein 1" EXACT [] is_a: PR:000025824 ! Axin [Term] id: PR:O15169-1 name: Axin-1 isoform 1 (human) def: "An Axin-1 isoform 1 that is encoded in the genome of human." [PMID:9230313, PRO:CNA] comment: Category=organism-sequence. synonym: "hAXIN1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O15169-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000025825 ! Axin-1 isoform 1 [Term] id: PR:000046444 name: Axin-1 phosphorylated 1 (human) def: "An Axin-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-481, and phosphoserine at positions 486 and 493 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046." [PRO:DAN, Reactome:R-HSA-206040] comment: Category=organism-modification. Note: The modified sites indicated here (Thr-481/Ser-486/Ser-493) are referred to as Thr-609/Ser-614/Ser-621 in the literature using the mouse sequence. [PRO:DAN, PMID:10581160] synonym: "hAXIN1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O15169, Thr-481, MOD:00047|Ser-486/Ser-493, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-206040 "PR:000046444 located_in GO:0005829" is_a: PR:O15169 ! Axin-1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046445 name: Axin-1 ubiquitinated 1 (human) def: "An Axin-1 (human) that has been ubiquitinated on the residue at the position equivalent to Lys-501 of the amino acid sequence represented by UniProtKB:O15169. UniProtKB:O15169, Lys-501, MOD:01148." [PRO:DAN, Reactome:R-HSA-4641133] comment: Category=organism-modification. Note: The modified site indicated here (Lys-501) is referred to as Lys-505 in the literature using the mouse Axin1 sequence. [PRO:DAN, PMID:20858899] synonym: "hAXIN1/Ubiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O15169, Lys-501, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4641133 "PR:000046445 located_in GO:0005829" is_a: PR:O15169 ! Axin-1 (human) relationship: has_part MOD:01148 ! ubiquitinylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046442 name: Axin-1 ADP-ribosylated form (human) def: "An Axin-1 (human) that includes at least one ADP-ribosylated residue. UniProtKB:O15169, MOD:00752." [PRO:DNx, Reactome:R-HSA-3640841] comment: Category=organism-modification. synonym: "hAXIN1/ADPribRes+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O15169, MOD:00752" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3640841 "PR:000046442 located_in GO:0005829" intersection_of: has_part MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue intersection_of: PR:O15169 ! Axin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046443 name: Axin-1 ADP-ribosylated and ubiquitinated form (human) def: "An Axin-1 (human) that includes at least one ADP-ribosylated residue and at least one ubiquitinated lysine. UniProtKB:O15169, MOD:00752|MOD:01148." [PRO:DNx, Reactome:R-HSA-3640864] comment: Category=organism-modification. synonym: "hAXIN1/ADPribUbiq+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O15169, MOD:00752|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3640864 "PR:000046443 located_in GO:0005829" intersection_of: has_part MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:O15169 ! Axin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O35625-1 name: Axin-1 isoform 1 (mouse) def: "An Axin-1 isoform 1 that is encoded in the genome of mouse." [PMID:9230313, PRO:HJD] comment: Category=organism-sequence. synonym: "mAXIN1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O35625-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000025825 ! Axin-1 isoform 1