[Term]
id: PR:000029910
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated as a result of activation of the MAPK pathway." [PMID:11231148, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000029917
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in frog." [PRO:CNA]
comment: Category=organism-modification.
synonym: "frog-BUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:000029916
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that lacks phosphorylated residues." [PRO:CNA]
comment: Category=modification.
synonym: "BUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1

[Term]
id: PR:000029913
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in frog." [PMID:11231148, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:Q98UH3).
synonym: "frog-BUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029912 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000029912
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated by autocatalysis." [PMID:11231148, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000029911
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1 in frog. Phosphorylation is observed during Meiosis I (prophase I, metaphase I, anaphase I, telophase I), and Meiosis II (prophase II, metaphase II)." [PMID:11231148, PRO:KER]
comment: Category=organism-modification. Kinase=("RPS6KA"; PR:P10665).
synonym: "frog-BUB1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000029910 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000004854
name: mitotic checkpoint serine/threonine-protein kinase BUB1
def: "A BUB1/BUB1B protein that is a translation product of the human BUB1 gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA]
comment: Category=gene.
synonym: "BUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A" EXACT []
synonym: "BUB1L" RELATED Gene-based []
xref: IUPHARobj:1949
is_a: PR:000035665 ! BUB1/BUB1B protein

[Term]
id: PR:O22806
name: mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
comment: Category=organism-gene.
synonym: "MAD3" RELATED Gene-based [UniProtKB:O22806]
synonym: "BUBR1" RELATED Gene-based [UniProtKB:O22806]
synonym: "F4P9.33" RELATED Gene-based [UniProtKB:O22806]
synonym: "At-BUBR1" EXACT PRO-short-label [PRO:DAN]
synonym: "At2g33560" RELATED Gene-based [UniProtKB:O22806]
synonym: "BUB1-related protein 1 (Arabidopsis thaliana)" EXACT [UniProtKB:O22806]
xref: UniProtKB:O22806
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template Araport:AT2G33560 ! BUBR1 (Arabidopsis thaliana)

[Term]
id: PR:O08901
name: mitotic checkpoint serine/threonine-protein kinase BUB1 (mouse)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of mouse." [OMA:O08901, PMID:19965387, PMID:20057499, PRO:KER]
comment: Category=organism-gene.
synonym: "Bub1" RELATED Gene-based [UniProtKB:O08901]
synonym: "mBUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A (mouse)" EXACT [UniProtKB:O08901]
xref: UniProtKB:O08901
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template MGI:1100510 ! Bub1 (mouse)

[Term]
id: PR:000035691
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that represents the basal phosphorylated state observed during interphase and mitosis." [PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "BUB1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1 phosphorylated" RELATED []
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035408
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (mouse)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in mouse." [PMID:11792804, PRO:KER]
comment: Category=organism-modification.
synonym: "mBUB1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "mBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000035406 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:O43683
name: mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of human." [PMID:10749118, PMID:11030144, PMID:11792804, PMID:12719470, PMID:15190214, PMID:15525512, PMID:15592459, PMID:16760428, PMID:17671183, PMID:17785528, PMID:20016069, PMID:20624902, PMID:20703093, PRO:KER]
comment: Category=organism-gene.
synonym: "BUB1" RELATED Gene-based [UniProtKB:O43683]
synonym: "BUB1L" RELATED Gene-based [UniProtKB:O43683]
synonym: "hBUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1A (human)" EXACT [UniProtKB:O43683]
xref: Reactome:R-HSA-377888 "PR:O43683 located_in GO:0005829"
xref: DTO:03100052
xref: UniProtKB:O43683
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template HGNC:1148 ! BUB1 (human)

[Term]
id: PR:000035420
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to DNA damage, mitosis or spindle depolymerization. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:10" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1 phosphorylated" RELATED []
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000035421
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10 in human. Example: UniProtKB:O43683-1, Ser-314, MOD:00046." [PMID:22071147, PMID:22099307, PRO:KER]
comment: Category=organism-modification. Kinase=("ATM"; PR:000035423).
synonym: "hBUB1/Phos:10" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
synonym: "UniProtKB:O43683-1, Ser-314, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035420 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 10
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000035401
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (yeast)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in yeast." [PMID:7969164, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:P41695).
synonym: "yBUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "yBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000029912 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035403
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been hyperphosphorylated within the amino-terminal noncatalytic region and induced by a lack of microtubule occupancy at kinetochores. Example: UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1 hyperphosphorylated" RELATED []
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000035404
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3 in frog. UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046." [PMID:15241477, PRO:KER]
comment: Category=organism-modification. Phosphorylation at Ser-500 is the most critical for checkpoint function. This form is observed during spindle disruption (nocodazole). Kinase=("MAPK"; PR:000000019).
synonym: "frog-BUB1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "xBUB1 hyperphosphorylated" RELATED []
synonym: "UniProtKB:Q6GPC9, Thr-493/Thr-650, MOD:00047|Ser-500/Ser-634, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000035403 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 3
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000035405
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in human." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hBUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:000035406
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated in response to spindle damage (including treatment with taxol)." [PMID:11792804, PMID:15525512, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1 phosphorylated" RELATED []
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035407
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4 in human." [PMID:11792804, PMID:15525512, PRO:KER]
comment: Category=organism-modification.
synonym: "hBUB1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035406 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 4
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:O22806-2
name: mitotic spindle checkpoint protein BUBR1 isoform 2 (Arabidopsis thaliana)
def: "A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-2." [PRO:DNx, UniProtKB:O22806]
comment: Category=organism-sequence.
synonym: "At-BUBR1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O22806-2
is_a: PR:O22806 ! mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:O22806-1
name: mitotic spindle checkpoint protein BUBR1 isoform 1 (Arabidopsis thaliana)
def: "A mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O22806-1." [PRO:DNx, UniProtKB:O22806]
comment: Category=organism-sequence.
synonym: "At-BUBR1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O22806-1
is_a: PR:O22806 ! mitotic spindle checkpoint protein BUBR1 (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:Q21776
name: mitotic checkpoint serine/threonine-protein kinase bub-1 (worm)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of worm." [PANTHER:PTHR14030:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "bub-1" RELATED Gene-based [UniProtKB:Q21776]
synonym: "R06C7.8" RELATED Gene-based [UniProtKB:Q21776]
synonym: "BUB1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "budding uninhibited by benzimidazole 1 (worm)" EXACT [UniProtKB:Q21776]
xref: UniProtKB:Q21776
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template WormBase:WBGene00000275 ! bub-1 (worm)

[Term]
id: PR:Q6GPC9
name: mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of frog." [PRO:DNx, UniProtKB:Q6GPC9]
comment: Category=organism-gene.
synonym: "bub1" RELATED Gene-based [UniProtKB:Q6GPC9]
synonym: "bub1.L" RELATED Gene-based [PRO:DAN]
synonym: "LOC398234" RELATED Gene-based [UniProtKB:Q6GPC9]
synonym: "frog-bub1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q6GPC9
intersection_of: only_in_taxon NCBITaxon:8355 ! Xenopus laevis
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template NCBIGene:398234 ! bub1 (frog)

[Term]
id: PR:O43683-1
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h1 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-1." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-1
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43683-3
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h3 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-3." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-3
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43683-2
name: mitotic checkpoint serine/threonine-protein kinase BUB1 isoform h2 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43683-2." [PRO:DNx, UniProtKB:O43683]
comment: Category=organism-sequence.
synonym: "hBUB1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43683-2
is_a: PR:O43683 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035399
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2 in human." [PMID:10198256, PMID:15525512, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1"; PR:O43683).
synonym: "hBUB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029912 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 2
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q54CV5
name: probable inactive serine/threonine-protein kinase bub1 (Dictyostelium discoideum)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is encoded in the genome of Dictyostelium discoideum." [PANTHER:PTHR14030:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "bub1" RELATED Gene-based [UniProtKB:Q54CV5]
synonym: "Dicty-BUB1" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0292676" RELATED Gene-based [UniProtKB:Q54CV5]
xref: UniProtKB:Q54CV5
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_gene_template dictyBase:DDB_G0292676 ! bub1 (Dictyostelium discoideum)

[Term]
id: PR:Q98UH3
name: mitotic checkpoint serine/threonine-protein kinase BUB1 sequence variant 1 (frog)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 (frog) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q98UH3." [PMID:11231148, PRO:DAN, PRO:KER]
comment: Category=organism-sequence. Note: There are multiple positions of variation with respect to the reference sequence (UniProtKB:Q6GPC9-1).
synonym: "frog-BUB1/var:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q98UH3
is_a: PR:Q6GPC9 ! mitotic checkpoint serine/threonine-protein kinase BUB1 (frog)
relationship: only_in_taxon NCBITaxon:8355 ! Xenopus laevis

[Term]
id: PR:000035419
name: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 1 (yeast)
def: "A BUB1 CDK-consensus sites phosphorylated form in yeast that has phosphorylation at Thr-566. This phosphorylation is essential for deactivating the spindle checkpoint in anaphase and adaptation to prolonged mitotic arrest. UniProtKB:P41695, Thr-566, MOD:00047." [PMID:21298086, PRO:KER]
comment: Category=organism-modification. Kinase=("CDK1"; PR:P00546).
synonym: "yBUB1/Phos:CDK-1" EXACT PRO-short-label [PRO:DAN]
synonym: "BUB1p phosphorylated" RELATED []
synonym: "UniProtKB:P41695, Thr-566, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000035413 ! BUB1 CDK-consensus sites phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C

[Term]
id: PR:000035418
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8 in human. Phosphorylation of Thr-609 is needed by phosphorylation by Plk1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:16760428, PRO:KER]
comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271). Kinase=("PLK1"; PR:P53350).
synonym: "hBUB1/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "hBUB1 phosphorylated" RELATED []
synonym: "UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035417 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035413
name: BUB1 CDK-consensus sites phosphorylated form
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that is phosphorylated on CDK consensus sites (S/T-P-X-K/R) located in the middle region of BUB1." [PMID:12606573, PMID:16760428, PRO:KER]
comment: Category=modification.
synonym: "BUB1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1

[Term]
id: PR:000035412
name: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 7 (human)
def: "A BUB1 CDK-consensus sites phosphorylated form in human. Phosphorylation occurs during mitosis and spindle disruption (e.g. with nocodazole). Thr-609 phosphorylation is critical for interaction with PLK1. Example: UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047." [PMID:16760428, PRO:KER]
comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271).
synonym: "hBUB1/Phos:7" EXACT PRO-short-label [PRO:JR]
synonym: "UniProtKB:O43683-1, Ser-593, MOD:00046|Thr-609, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000035413 ! BUB1 CDK-consensus sites phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035411
name: mitotic checkpoint serine/threonine-protein kinase BUB1 CDK-consensus sites phosphorylated 6 (Schizosaccharomyces pombe 972h-)
def: "A BUB1 CDK-consensus sites phosphorylated form in Schizosaccharomyces pombe 972h-. The exact combination of phosphorylated sites is not known but may involve Thr-340, Thr-423, Thr-455, and/or Ser-466 of the amino acid sequence represented by UniProtKB:O94751. Phosphorylation occurs during Meiosis I or spindle disruption (tubulin mutant). Example: UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)." [PMID:12606573, PRO:DAN, PRO:KER]
comment: Category=organism-modification. Kinase=("CDC2"; PR:P04551).
synonym: "Spom972h-BUB1/Phos:6" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:O94751, (Thr-340, MOD:00047 and/or Thr-423, MOD:00047 and/or Thr-455, MOD:00047 and/or Ser-466, MOD:00046)" NARROW PRO-proteoform-std [PRO:DAN]
is_a: PR:000035413 ! BUB1 CDK-consensus sites phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue
relationship: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-

[Term]
id: PR:000035410
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 (Schizosaccharomyces pombe 972h-)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5 in Schizosaccharomyces pombe 972h-. This form represents the basal phosphorylated state observed during interphase and mitosis." [PMID:12606573, PRO:KER]
comment: Category=organism-modification.
synonym: "Spom972h-BUB1/Phos:5" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000035691 ! mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 5
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035417
name: mitotic checkpoint serine/threonine-protein kinase BUB1 phosphorylated 8
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 that has been phosphorylated by CDK1 and PLK1. Example: UniProtKB:O43683-1, Thr-609, MOD:00047|MOD:00696." [PMID:11792804, PMID:15525512, PRO:KER]
comment: Category=modification.
synonym: "BUB1/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "BUB1 phosphorylated" RELATED []
is_a: PR:000004854 ! mitotic checkpoint serine/threonine-protein kinase BUB1
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000035416
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (mouse)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in mouse." [PRO:CNA]
comment: Category=organism-modification.
synonym: "mBUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:000035415
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (yeast)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in yeast." [PRO:CNA]
comment: Category=organism-modification.
synonym: "yBUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form

[Term]
id: PR:000035414
name: mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form (Schizosaccharomyces pombe 972h-)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form in Schizosaccharomyces pombe 972h-." [PRO:CNA]
comment: Category=organism-modification.
synonym: "Spom972h-BUB1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000029916 ! mitotic checkpoint serine/threonine-protein kinase BUB1 unphosphorylated form