[Term]
id: PR:000045714
name: E3 ubiquitin-protein ligase CBL phosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase CBL (human) that has been phosphorylated at Tyr-731. UniProtKB:P22681, Tyr-731, MOD:00048." [PMID:14739300, iPTMnet:P22681]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14739300). Status=unreviewed.
synonym: "hCBL/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22681, Tyr-731, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P22681 ! E3 ubiquitin-protein ligase CBL (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026223
name: E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1 in human. UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx, Reactome:R-HSA-182923, Reactome:R-HSA-182940]
comment: Category=organism-modification.
synonym: "phospho-CLB" RELATED []
synonym: "hCBL/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22681-1, Tyr-371, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-182923 "PR:000026223 located_in GO:0005886"
xref: Reactome:R-HSA-182940 "PR:000026223 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026188 ! E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000046577
name: E3 ubiquitin-protein ligase CBL phosphorylated 2 (human)
def: "An E3 ubiquitin-protein ligase CBL (human) that has been post-translationally modified to include phosphotyrosine at positions 700, 731 and 774 of the amino acid sequence represented by UniProtKB:P22681. UniProtKB:P22681, Tyr-700/Tyr-731/Tyr-774, MOD:00048." [PRO:DNx, Reactome:R-HSA-912656]
comment: Category=organism-modification.
synonym: "hCBL/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22681, Tyr-700/Tyr-731/Tyr-774, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-912656 "PR:000046577 located_in GO:0005829"
is_a: PR:P22681 ! E3 ubiquitin-protein ligase CBL (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000005070
name: E3 ubiquitin-protein ligase CBL
def: "A protein that is a translation product of the human CBL gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CBL" EXACT PRO-short-label [PRO:DNx]
synonym: "CBL2" RELATED Gene-based []
synonym: "RNF55" RELATED Gene-based []
synonym: "proto-oncogene c-Cbl" EXACT []
synonym: "RING finger protein 55" EXACT []
synonym: "signal transduction protein CBL" EXACT []
synonym: "RING-type E3 ubiquitin transferase CBL" EXACT []
synonym: "casitas B-lineage lymphoma proto-oncogene" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P22682
name: E3 ubiquitin-protein ligase CBL (mouse)
def: "An E3 ubiquitin-protein ligase CBL that is encoded in the genome of mouse." [OMA:P22682, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cbl" RELATED Gene-based [UniProtKB:P22682]
synonym: "mCBL" EXACT PRO-short-label [PRO:DNx]
synonym: "proto-oncogene c-Cbl (mouse)" EXACT [UniProtKB:P22682]
synonym: "signal transduction protein CBL (mouse)" EXACT [UniProtKB:P22682]
synonym: "RING-type E3 ubiquitin transferase CBL (mouse)" EXACT [UniProtKB:P22682]
synonym: "casitas B-lineage lymphoma proto-oncogene (mouse)" EXACT [UniProtKB:P22682]
xref: UniProtKB:P22682
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000005070 ! E3 ubiquitin-protein ligase CBL
relationship: has_gene_template MGI:88279 ! Cbl (mouse)

[Term]
id: PR:P22681-1
name: E3 ubiquitin-protein ligase CBL isoform 1 (human)
def: "An E3 ubiquitin-protein ligase CBL isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hCBL/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22681-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026186 ! E3 ubiquitin-protein ligase CBL isoform 1

[Term]
id: PR:P22681
name: E3 ubiquitin-protein ligase CBL (human)
def: "An E3 ubiquitin-protein ligase CBL that is encoded in the genome of human." [PRO:DNx, UniProtKB:P22681]
comment: Category=organism-gene.
synonym: "CBL" RELATED Gene-based [UniProtKB:P22681]
synonym: "CBL2" RELATED Gene-based [UniProtKB:P22681]
synonym: "hCBL" EXACT PRO-short-label [PRO:DNx]
synonym: "RNF55" RELATED Gene-based [UniProtKB:P22681]
synonym: "proto-oncogene c-Cbl (human)" EXACT [UniProtKB:P22681]
synonym: "RING finger protein 55 (human)" EXACT [UniProtKB:P22681]
synonym: "signal transduction protein CBL (human)" EXACT [UniProtKB:P22681]
synonym: "RING-type E3 ubiquitin transferase CBL (human)" EXACT [UniProtKB:P22681]
synonym: "casitas B-lineage lymphoma proto-oncogene (human)" EXACT [UniProtKB:P22681]
xref: Reactome:R-HSA-112192 "PR:P22681 located_in GO:0005886"
xref: Reactome:R-HSA-112199 "PR:P22681 located_in GO:0005829"
xref: UniProtKB:P22681
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005070 ! E3 ubiquitin-protein ligase CBL
relationship: has_gene_template HGNC:1541 ! CBL (human)

[Term]
id: PR:000026186
name: E3 ubiquitin-protein ligase CBL isoform 1
def: "An E3 ubiquitin-protein ligase CBL that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22681-1 or a 1:1 ortholog thereof." [PRO:CNx]
comment: Category=sequence.
synonym: "CBL/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000005070 ! E3 ubiquitin-protein ligase CBL

[Term]
id: PR:000026188
name: E3 ubiquitin-protein ligase CBL isoform 1 phosphorylated 1
def: "An E3 ubiquitin-protein ligase CBL isoform 1 that has been phosphorylated by tyrosine kinase receptors, such as EGFR or INSR. This tyrosine phosphorylation is necessary for activation of the ubiquitin ligase activity. Example: UniProtKB:P22681-1, Tyr-371, MOD:00048." [PMID:11997497, PMID:15117950, PRO:CNx, Reactome:R-HSA-182923, Reactome:R-HSA-182940]
comment: Category=modification.
synonym: "phospho-CLB" RELATED []
synonym: "CBL/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000026186 ! E3 ubiquitin-protein ligase CBL isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine