[Term]
id: PR:000037511
name: G1/S-specific cyclin-D1 unphosphorylated 1 (human)
def: "A G1/S-specific cyclin-D1 (human) that lacks phosphorylation at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385. UniProtKB:P24385, Thr-286, PR:000026291." [PMID:17407548, PRO:KER]
comment: Category=organism-modification.
synonym: "hCCND1/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P24385, Thr-286, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P24385 ! G1/S-specific cyclin-D1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P24385-1
name: G1/S-specific cyclin-D1 isoform 1 (human)
def: "A G1/S-specific cyclin-D1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCCND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P24385-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039111 ! G1/S-specific cyclin-D1 isoform 1

[Term]
id: PR:P24385
name: G1/S-specific cyclin-D1 (human)
def: "A G1/S-specific cyclin-D1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "BCL1" RELATED Gene-based [UniProtKB:P24385]
synonym: "CCND1" RELATED Gene-based [UniProtKB:P24385]
synonym: "PRAD1" RELATED Gene-based [UniProtKB:P24385]
synonym: "hCCND1" EXACT PRO-short-label [PRO:DNx]
synonym: "BCL-1 (human)" EXACT [UniProtKB:P24385]
synonym: "BCL-1 oncogene (human)" EXACT [UniProtKB:P24385]
synonym: "PRAD1 oncogene (human)" EXACT [UniProtKB:P24385]
synonym: "B-cell lymphoma 1 protein (human)" EXACT [UniProtKB:P24385]
xref: Reactome:R-HSA-113832 "PR:P24385 located_in GO:0005654"
xref: Reactome:R-HSA-68328 "PR:P24385 located_in GO:0005829"
xref: UniProtKB:P24385
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005121 ! G1/S-specific cyclin-D1
relationship: has_gene_template HGNC:1582 ! CCND1 (human)

[Term]
id: PR:000037512
name: G1/S-specific cyclin-D1 phosphorylated and multi-ubiquitinated 1 (human)
def: "A G1/S-specific cyclin-D1 (human) that has been both phosphorylated at the residue equivalent to Thr-286 of the amino acid sequence represented by UniProtKB:P24385 and been multi-ubiquitinated." [PMID:17081987, PMID:17407548, PRO:KER]
comment: Category=organism-modification. UbLigase=("FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex"; PR:000037513). Kinase=("GSK3B"; PR:P49841; Thr-286).
synonym: "hCCND1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "multi-ubiquitinated phospho-(T286) Cyclin D1 (human)" EXACT [Reactome:R-HSA-177997]
xref: Reactome:R-HSA-177997 "PR:000037512 located_in GO:0005829"
is_a: PR:P24385 ! G1/S-specific cyclin-D1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000005121
name: G1/S-specific cyclin-D1
def: "A cyclin-D that is a translation product of the human CCND1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "BCL1" RELATED Gene-based []
synonym: "BCL-1" EXACT []
synonym: "CCND1" EXACT PRO-short-label [PRO:DNx]
synonym: "Cyl-1" RELATED Gene-based []
synonym: "PRAD1" RELATED Gene-based []
synonym: "BCL-1 oncogene" EXACT []
synonym: "PRAD1 oncogene" EXACT []
synonym: "B-cell lymphoma 1 protein" EXACT []
is_a: PR:000050022 ! cyclin-D

[Term]
id: PR:000027132
name: G1/S-specific cyclin-D1 phosphorylated 1 (human)
def: "A G1/S-specific cyclin-D1 phosphorylated 1 in human. UniProtKB:P24385, Thr-286, MOD:00047." [PRO:DAN, Reactome:R-HSA-75811, Reactome:R-HSA-75813]
comment: Category=organism-modification.
synonym: "hCCND1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-T286-CCND1 (human)" EXACT [Reactome:R-HSA-75811, Reactome:R-HSA-75813]
synonym: "UniProtKB:P24385, Thr-286, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-75811 "PR:000027132 located_in GO:0005654"
xref: Reactome:R-HSA-75813 "PR:000027132 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027131 ! G1/S-specific cyclin-D1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine