[Term]
id: PR:000005258
name: cyclin-dependent kinase 5
def: "A CDK2-related kinase that is a translation product of the human CDK5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CDK5" EXACT PRO-short-label [PRO:DNx]
synonym: "CRK6" EXACT []
synonym: "CDKN5" RELATED Gene-based []
synonym: "PSSALRE" RELATED Gene-based []
synonym: "TPKII catalytic subunit" EXACT []
synonym: "cell division protein kinase 5" EXACT []
synonym: "cyclin-dependent-like kinase 5" EXACT []
synonym: "serine/threonine-protein kinase PSSALRE" EXACT []
synonym: "tau protein kinase II catalytic subunit" EXACT []
xref: IUPHARobj:1977
is_a: PR:000003270 ! CDK2-related kinase

[Term]
id: PR:Q00535-2
name: cyclin-dependent kinase 5 isoform h2 (human)
def: "A cyclin-dependent kinase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00535-2." [PRO:DNx, UniProtKB:Q00535]
comment: Category=organism-sequence.
synonym: "hCDK5/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase 5 isoform CDK5-SV (human)" EXACT [UniProtKB:Q00535]
xref: UniProtKB:Q00535-2
is_a: PR:Q00535 ! cyclin-dependent kinase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00535-1
name: cyclin-dependent kinase 5 isoform 1 (human)
def: "A cyclin-dependent kinase 5 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCDK5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00535-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000040211 ! cyclin-dependent kinase 5 isoform 1

[Term]
id: PR:Q00535
name: cyclin-dependent kinase 5 (human)
def: "A cyclin-dependent kinase 5 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "CDK5" RELATED Gene-based [UniProtKB:Q00535]
synonym: "CDKN5" RELATED Gene-based [UniProtKB:Q00535]
synonym: "hCDK5" EXACT PRO-short-label [PRO:DNx]
synonym: "PSSALRE" RELATED Gene-based [UniProtKB:Q00535]
synonym: "TPKII catalytic subunit (human)" EXACT [UniProtKB:Q00535]
synonym: "cell division protein kinase 5 (human)" EXACT [PRO:DNx]
synonym: "cyclin-dependent-like kinase 5 (human)" EXACT [UniProtKB:Q00535]
synonym: "serine/threonine-protein kinase PSSALRE (human)" EXACT [UniProtKB:Q00535]
synonym: "tau protein kinase II catalytic subunit (human)" EXACT [UniProtKB:Q00535]
xref: Reactome:R-HSA-180064 "PR:Q00535 located_in GO:0005829"
xref: Reactome:R-HSA-8863586 "PR:Q00535 located_in GO:0005654"
xref: DTO:03100071
xref: UniProtKB:Q00535
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005258 ! cyclin-dependent kinase 5
relationship: has_gene_template HGNC:1774 ! CDK5 (human)

[Term]
id: PR:000046677
name: cyclin-dependent kinase 5 phosphorylated 2 (human)
def: "A cyclin-dependent kinase 5 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-15 and phosphoserine at position 159 of the amino acid sequence represented by UniProtKB:Q00535-1. Example: UniProtKB:Q00535-1, Tyr-15, MOD:00048|Ser-159, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805249]
comment: Category=organism-modification.
synonym: "hCDK5/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00535-1, Tyr-15, MOD:00048|Ser-159, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805249 "PR:000046677 located_in GO:0005654"
is_a: PR:Q00535 ! cyclin-dependent kinase 5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046676
name: cyclin-dependent kinase 5 phosphorylated 1 (human)
def: "A cyclin-dependent kinase 5 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-15 of the amino acid sequence represented by UniProtKB:Q00535. UniProtKB:Q00535, Tyr-15, MOD:00048." [PRO:DNx, Reactome:R-HSA-399809]
comment: Category=organism-modification.
synonym: "hCDK5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00535, Tyr-15, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-399809 "PR:000046676 located_in GO:0005829"
is_a: PR:Q00535 ! cyclin-dependent kinase 5 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens