[Term] id: PR:P38936 name: cyclin-dependent kinase inhibitor 1 (human) def: "A cyclin-dependent kinase inhibitor 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P38936] comment: Category=organism-gene. Requested by=PubChem. synonym: "CIP1" RELATED Gene-based [UniProtKB:P38936] synonym: "MDA6" RELATED Gene-based [UniProtKB:P38936] synonym: "PIC1" RELATED Gene-based [UniProtKB:P38936] synonym: "SDI1" RELATED Gene-based [UniProtKB:P38936] synonym: "WAF1" RELATED Gene-based [UniProtKB:P38936] synonym: "CAP20" RELATED Gene-based [UniProtKB:P38936] synonym: "CDKN1" RELATED Gene-based [UniProtKB:P38936] synonym: "CDKN1A" RELATED Gene-based [UniProtKB:P38936] synonym: "hCDKN1A" EXACT PRO-short-label [PRO:DNx] synonym: "p21 (human)" BROAD [UniProtKB:P38936] synonym: "MDA-6 (human)" EXACT [UniProtKB:P38936] synonym: "CDK-interacting protein 1 (human)" EXACT [UniProtKB:P38936] synonym: "melanoma differentiation-associated protein 6 (human)" EXACT [UniProtKB:P38936] xref: UniProtKB:P38936 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000005274 ! cyclin-dependent kinase inhibitor 1 relationship: has_gene_template HGNC:1784 ! CDKN1A (human) [Term] id: PR:000005274 name: cyclin-dependent kinase inhibitor 1 def: "A protein that is a translation product of the human CDKN1A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "p21" BROAD [PRO:DNx] synonym: "CIP1" RELATED Gene-based [] synonym: "MDA6" RELATED Gene-based [] synonym: "PIC1" RELATED Gene-based [] synonym: "SDI1" RELATED Gene-based [] synonym: "WAF1" RELATED Gene-based [] synonym: "CAP20" RELATED Gene-based [] synonym: "CDKN1" RELATED Gene-based [] synonym: "MDA-6" EXACT [] synonym: "CDKN1A" EXACT PRO-short-label [PRO:DNx] synonym: "CDK-interacting protein 1" EXACT [] synonym: "melanoma differentiation-associated protein" EXACT [] synonym: "melanoma differentiation-associated protein 6" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000046680 name: cyclin-dependent kinase inhibitor 1, initiator methionine removed phosphorylated 2 (human) def: "A cyclin-dependent kinase inhibitor 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 130 of the amino acid sequence represented by UniProtKB:P38936. UniProtKB:P38936, 2-164, Ser-130, MOD:00046." [PRO:DNx, Reactome:R-HSA-187857] comment: Category=organism-modification. synonym: "hCDKN1A/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000190079, Ser-130, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P38936, 2-164, Ser-130, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-187857 "PR:000046680 located_in GO:0005654" is_a: PR:P38936 ! cyclin-dependent kinase inhibitor 1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000046681 name: cyclin-dependent kinase inhibitor 1, initiator methionine removed phosphorylated 3 (human) def: "A cyclin-dependent kinase inhibitor 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 145 of the amino acid sequence represented by UniProtKB:P38936. UniProtKB:P38936, 2-164, Thr-145, MOD:00047." [PRO:DNx, Reactome:R-HSA-198614] comment: Category=organism-modification. synonym: "hCDKN1A/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000190079, Thr-145, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P38936, 2-164, Thr-145, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-198614 "PR:000046681 located_in GO:0005829" is_a: PR:P38936 ! cyclin-dependent kinase inhibitor 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045772 name: cyclin-dependent kinase inhibitor 1 phosphorylated 1 (human) def: "A cyclin-dependent kinase inhibitor 1 (human) that has been phosphorylated at Thr-57. UniProtKB:P38936, Thr-57, MOD:00047." [PMID:19822666, iPTMnet:P38936] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19822666). Status=unreviewed. synonym: "hCDKN1A/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38936, Thr-57, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P38936 ! cyclin-dependent kinase inhibitor 1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046679 name: cyclin-dependent kinase inhibitor 1, initiator methionine removed form (human) def: "A cyclin-dependent kinase inhibitor 1 (human) that has had the initiator methionine removed. UniProtKB:P38936, 2-164." [PRO:DNx, Reactome:R-HSA-182585] comment: Category=organism-modification. synonym: "PRO_0000190079" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hCDKN1A/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P38936, 2-164" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-182512 "PR:000046679 located_in GO:0005829" xref: Reactome:R-HSA-182585 "PR:000046679 located_in GO:0005654" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P38936 ! cyclin-dependent kinase inhibitor 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens