[Term] id: PR:P49450-1 name: histone H3-like centromeric protein A isoform h1 (human) def: "A histone H3-like centromeric protein A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49450-1." [PRO:DNx, UniProtKB:P49450] comment: Category=organism-sequence. synonym: "hCENPA/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P49450-1 is_a: PR:P49450 ! histone H3-like centromeric protein A (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P49450-2 name: histone H3-like centromeric protein A isoform h2 (human) def: "A histone H3-like centromeric protein A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49450-2." [PRO:DNx, UniProtKB:P49450] comment: Category=organism-sequence. synonym: "hCENPA/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P49450-2 is_a: PR:P49450 ! histone H3-like centromeric protein A (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000005323 name: histone H3-like centromeric protein A def: "A core histone that is a translation product of the human CENPA gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CENPA" EXACT PRO-short-label [PRO:DNx] synonym: "CENP-A" BROAD [PRO:DNx] synonym: "centromere protein A" BROAD [PRO:DNx] synonym: "centromere autoantigen A" EXACT [] is_a: PR:000043452 ! core histone [Term] id: PR:000045801 name: histone H3-like centromeric protein A phosphorylated 1 (human) def: "A histone H3-like centromeric protein A (human) that has been phosphorylated on the residue at the position equivalent to Ser-68 of the amino acid sequence represented by UniProtKB:P49450-1. Example: UniProtKB:P49450-1, Ser-68, MOD:00046." [PMID:25556658, iPTMnet:P49450] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:25556658). Status=unreviewed. synonym: "hCENPA/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P49450-1, Ser-68, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P49450 ! histone H3-like centromeric protein A (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000035364 name: histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1 (human) def: "A histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1 in human. UniProtKB:P49450, 2-140, Ser-7, MOD:00046." [HIstome_var_Hs:Histone_H3-like_centromeric_protein_A, PMID:11756469, PMID:14667408, PMID:15592459, PRO:KER] comment: Category=organism-modification. Kinase=("AURK"; PR:000035365). synonym: "hCENPA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "H3-like_centromeric_protein_A:H3S6ph" BROAD [HIstome_ptm_Hs:H3S6ph] synonym: "UniProtKB:P49450, 2-140, Ser-7, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035363 ! histone H3-like centromeric protein A, initiator methionine removed phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P49450 name: histone H3-like centromeric protein A (human) def: "A histone H3-like centromeric protein A that is encoded in the genome of human." [PMID:15592459, PRO:KER] comment: Category=organism-gene. synonym: "CENPA" RELATED Gene-based [UniProtKB:P49450] synonym: "hCENPA" EXACT PRO-short-label [PRO:DNx] synonym: "CENP-A (human)" EXACT [UniProtKB:P49450] synonym: "centromere protein A (human)" EXACT [UniProtKB:P49450] synonym: "centromere autoantigen A (human)" EXACT [UniProtKB:P49450] xref: Reactome:R-HSA-375317 "PR:P49450 located_in GO:0005829" xref: Reactome:R-HSA-606322 "PR:P49450 located_in GO:0005654" xref: UniProtKB:P49450 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000005323 ! histone H3-like centromeric protein A relationship: has_gene_template HGNC:1851 ! CENPA (human)