[Term]
id: PR:000005365
name: liver carboxylesterase 1
def: "A protein that is a translation product of the human CES1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "REH" EXACT []
synonym: "TGH" BROAD [PRO:DNx]
synonym: "ACAT" EXACT []
synonym: "CES1" EXACT PRO-short-label [PRO:DNx]
synonym: "CES2" RELATED Gene-based []
synonym: "ES-x" EXACT []
synonym: "HMSE" EXACT []
synonym: "SES1" RELATED Gene-based []
synonym: "egasyn" BROAD [PRO:DNx]
synonym: "serine esterase 1" EXACT []
synonym: "retinyl ester hydrolase" EXACT []
synonym: "cocaine carboxylesterase" EXACT []
synonym: "triacylglycerol hydrolase" BROAD [PRO:DNx]
synonym: "brain carboxylesterase hBr1" EXACT []
synonym: "monocyte/macrophage serine esterase" EXACT []
synonym: "acyl-coenzyme A:cholesterol acyltransferase" EXACT []
xref: IUPHARobj:2592
is_a: PR:000000001 ! protein

[Term]
id: PR:P23141
name: liver carboxylesterase 1 (human)
def: "A liver carboxylesterase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23141]
comment: Category=organism-gene.
synonym: "CES1" RELATED Gene-based [UniProtKB:P23141]
synonym: "CES2" RELATED Gene-based [UniProtKB:P23141]
synonym: "SES1" RELATED Gene-based [UniProtKB:P23141]
synonym: "hCE-1" EXACT [UniProtKB:P23141]
synonym: "hCES1" EXACT PRO-short-label [PRO:DNx]
synonym: "CEH (human)" EXACT [UniProtKB:P23141]
synonym: "REH (human)" EXACT [UniProtKB:P23141]
synonym: "TGH (human)" EXACT [UniProtKB:P23141]
synonym: "ACAT (human)" EXACT [UniProtKB:P23141]
synonym: "CE-1 (human)" EXACT [UniProtKB:P23141]
synonym: "HMSE (human)" EXACT [UniProtKB:P23141]
synonym: "egasyn (human)" EXACT [UniProtKB:P23141]
synonym: "serine esterase 1 (human)" EXACT [UniProtKB:P23141]
synonym: "carboxylesterase 1 (human)" EXACT [UniProtKB:P23141]
synonym: "retinyl ester hydrolase (human)" EXACT [UniProtKB:P23141]
synonym: "cocaine carboxylesterase (human)" EXACT [UniProtKB:P23141]
synonym: "triacylglycerol hydrolase (human)" EXACT [UniProtKB:P23141]
synonym: "brain carboxylesterase hBr1 (human)" EXACT [UniProtKB:P23141]
synonym: "cholesteryl ester hydrolase (human)" EXACT [UniProtKB:P23141]
synonym: "monocyte/macrophage serine esterase (human)" EXACT [UniProtKB:P23141]
synonym: "methylumbelliferyl-acetate deacetylase 1 (human)" EXACT [UniProtKB:P23141]
synonym: "acyl-coenzyme A:cholesterol acyltransferase (human)" EXACT [UniProtKB:P23141]
xref: UniProtKB:P23141
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005365 ! liver carboxylesterase 1
relationship: has_gene_template HGNC:1863 ! CES1 (human)

[Term]
id: PR:000046690
name: liver carboxylesterase 1, signal peptide removed form (human)
def: "A liver carboxylesterase 1 (human) that has had the signal peptide removed. UniProtKB:P23141, 18-567." [PRO:DNx, Reactome:R-HSA-2429659]
comment: Category=organism-modification.
synonym: "hCES1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000391359" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P23141, 18-567" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2429659 "PR:000046690 located_in GO:0005788"
intersection_of: PR:P23141 ! liver carboxylesterase 1 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23141-3
name: liver carboxylesterase 1 isoform h3 (human)
def: "A liver carboxylesterase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23141-3." [PRO:DNx, UniProtKB:P23141]
comment: Category=organism-sequence.
synonym: "hCES1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23141-3
is_a: PR:P23141 ! liver carboxylesterase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23141-2
name: liver carboxylesterase 1 isoform h2 (human)
def: "A liver carboxylesterase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23141-2." [PRO:DNx, UniProtKB:P23141]
comment: Category=organism-sequence.
synonym: "hCES1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23141-2
is_a: PR:P23141 ! liver carboxylesterase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23141-1
name: liver carboxylesterase 1 isoform h1 (human)
def: "A liver carboxylesterase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23141-1." [PRO:DNx, UniProtKB:P23141]
comment: Category=organism-sequence.
synonym: "hCES1/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23141-1
is_a: PR:P23141 ! liver carboxylesterase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens