[Term]
id: PR:P11182
name: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (human)
def: "A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11182]
comment: Category=organism-gene.
synonym: "DBT" RELATED Gene-based [UniProtKB:P11182]
synonym: "hDBT" EXACT PRO-short-label [PRO:DNx]
synonym: "BCATE2" RELATED Gene-based [UniProtKB:P11182]
synonym: "BCKADE2 (human)" EXACT [UniProtKB:P11182]
synonym: "BCKAD-E2 (human)" EXACT [UniProtKB:P11182]
synonym: "BCOADC-E2 (human)" EXACT [UniProtKB:P11182]
synonym: "dihydrolipoamide branched chain transacylase (human)" EXACT [UniProtKB:P11182]
synonym: "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase (human)" EXACT [UniProtKB:P11182]
synonym: "branched chain 2-oxo-acid dehydrogenase complex component E2 (human)" EXACT [UniProtKB:P11182]
synonym: "52 kDa mitochondrial autoantigen of primary biliary cirrhosis (human)" EXACT [UniProtKB:P11182]
synonym: "branched-chain alpha-keto acid dehydrogenase complex component E2 (human)" EXACT [UniProtKB:P11182]
synonym: "dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (human)" EXACT [UniProtKB:P11182]
xref: UniProtKB:P11182
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006300 ! lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
relationship: has_gene_template HGNC:2698 ! DBT (human)

[Term]
id: PR:000006300
name: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
def: "A protein that is a translation product of the human DBT gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DBT" EXACT PRO-short-label [PRO:DNx]
synonym: "BCATE2" RELATED Gene-based []
synonym: "BCKADE2" EXACT []
synonym: "BCKAD-E2" EXACT []
synonym: "dihydrolipoamide branched chain transacylase" EXACT []
synonym: "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase" EXACT []
synonym: "branched-chain alpha-keto acid dehydrogenase complex component E2" EXACT []
synonym: "dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P11182-1
name: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1 (human)
def: "A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hDBT/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11182-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038831 ! lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1

[Term]
id: PR:000047137
name: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial, transit peptide removed form (human)
def: "A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P11182, 62-482." [PRO:DNx, Reactome:R-HSA-6792584]
comment: Category=organism-modification.
synonym: "PRO_0000020489" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hDBT/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11182, 62-482" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6792584 "PR:000047137 located_in GO:0005759"
intersection_of: PR:P11182 ! lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047138
name: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial, transit peptide removed lipoylated 1 (human)
def: "A lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (human) that has had the transit peptide removed and has been post-translationally modified to include lipoylated lysine at position 105 of the amino acid sequence represented by UniProtKB:P11182. UniProtKB:P11182, 62-482, Lys-105, MOD:00127." [PRO:DAN, Reactome:R-HSA-70017]
comment: Category=organism-modification. Note: The modified site indicated here (Lys-105) is referred to as Lys-44 in some manuscripts. [PRO:DAN, PMID:11839747]
synonym: "hDBT/TransPep-/Lipo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000020489, Lys-105, MOD:00127" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P11182, 62-482, Lys-105, MOD:00127" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-70017 "PR:000047138 located_in GO:0005759"
is_a: PR:P11182 ! lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (human)
relationship: has_part MOD:00127 ! N6-lipoyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000725 ! transit_peptide