[Term]
id: PR:Q01094
name: transcription factor E2F1 (human)
def: "A transcription factor E2F1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q01094]
comment: Category=organism-gene.
synonym: "E2F1" RELATED Gene-based [UniProtKB:Q01094]
synonym: "RBBP3" RELATED Gene-based [UniProtKB:Q01094]
synonym: "hE2F1" EXACT PRO-short-label [PRO:DNx]
synonym: "PBR3 (human)" EXACT [UniProtKB:Q01094]
synonym: "E2F-1 (human)" EXACT [UniProtKB:Q01094]
synonym: "RBAP-1 (human)" EXACT [UniProtKB:Q01094]
synonym: "RBBP-3 (human)" EXACT [UniProtKB:Q01094]
synonym: "pRB-binding protein E2F-1 (human)" EXACT [UniProtKB:Q01094]
synonym: "retinoblastoma-binding protein 3 (human)" EXACT [UniProtKB:Q01094]
synonym: "retinoblastoma-associated protein 1 (human)" EXACT [UniProtKB:Q01094]
xref: Reactome:R-HSA-68639 "PR:Q01094 located_in GO:0005654"
xref: UniProtKB:Q01094
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006852 ! transcription factor E2F1
relationship: has_gene_template HGNC:3113 ! E2F1 (human)

[Term]
id: PR:Q01094-1
name: transcription factor E2F1 isoform 1 (human)
def: "A transcription factor E2F1 isoform 1 that is encoded in the genome of human." [PRO:PD]
comment: Category=organism-sequence.
synonym: "hE2F1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q01094-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028767 ! transcription factor E2F1 isoform 1

[Term]
id: PR:000045867
name: transcription factor E2F1 phosphorylated 1 (human)
def: "A transcription factor E2F1 (human) that has been phosphorylated at Ser-403. UniProtKB:Q01094, Ser-403, MOD:00046." [PMID:20447425, iPTMnet:Q01094]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20447425). Status=unreviewed.
synonym: "hE2F1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q01094, Ser-403, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q01094 ! transcription factor E2F1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028770
name: transcription factor E2F1 isoform 1 acetylated 1 (human)
def: "A transcription factor E2F1 isoform 1 acetylated 1 in human. Acetylation increases DNA binding and transcriptional activation. UniProtKB:Q01094-1, Lys-117/Lys-120/Lys-125, MOD:00064." [PMID:10753885, PRO:PD]
comment: Category=organism-modification. Acetylase=("CREBBP/EP300"; PR:000027108).
synonym: "hE2F1/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q01094-1, Lys-117/Lys-120/Lys-125, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028769 ! transcription factor E2F1 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000006852
name: transcription factor E2F1
def: "An E2F protein that is a translation product of the human E2F1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "E2F1" EXACT PRO-short-label [PRO:DNx]
synonym: "PBR3" EXACT []
synonym: "E2F-1" EXACT []
synonym: "RBBP3" RELATED Gene-based []
synonym: "RBAP-1" EXACT []
synonym: "RBBP-3" EXACT []
synonym: "PRB-binding protein E2F-1" EXACT []
synonym: "retinoblastoma-binding protein 3" EXACT []
synonym: "retinoblastoma-associated protein 1" EXACT []
is_a: PR:000050007 ! E2F protein

[Term]
id: PR:000047232
name: transcription factor E2F1 phosphorylated form (human)
def: "A transcription factor E2F1 (human) that includes at least one phosphorylated residue. UniProtKB:Q01094, MOD:00696." [PRO:DNx, Reactome:R-HSA-187911]
comment: Category=organism-modification.
synonym: "hE2F1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q01094, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-187911 "PR:000047232 located_in GO:0005654"
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:Q01094 ! transcription factor E2F1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens