[Term] id: PR:P00533-4 name: epidermal growth factor receptor isoform h4 (human) def: "An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-4." [PRO:DNx, UniProtKB:P00533] comment: Category=organism-sequence. synonym: "hEGFR/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P00533-4 is_a: PR:P00533 ! epidermal growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047261 name: epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified by autocatalysis to include phosphotyrosine at positions 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DAN, Reactome:R-HSA-180287] comment: Category=organism-modification. synonym: "hEGFR/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016665, Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00533, 25-1210, Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-180287 "PR:000047261 located_in GO:0005886" is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047262 name: epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 1016, 1069, 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-179803, Reactome:R-HSA-8869138] comment: Category=organism-modification. synonym: "hEGFR/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016665, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00533, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-179803 "PR:000047262 located_in GO:0005886" xref: Reactome:R-HSA-8869138 "PR:000047262 located_in GO:0030665" is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027477 name: epidermal growth factor receptor isoform 1, signal peptide removed form (human) def: "An epidermal growth factor receptor isoform 1, signal peptide removed form in human. UniProtKB:P00533-1, 25-1210." [PMID:18789131, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000016665" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hEGFR/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027476 ! epidermal growth factor receptor isoform 1, signal peptide removed form [Term] id: PR:000027479 name: epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human) def: "An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD] comment: Category=organism-modification. synonym: "hEGFR/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016665, Tyr-869, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027478 ! epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine [Term] id: PR:P00533-3 name: epidermal growth factor receptor isoform h3 (human) def: "An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-3." [PRO:DNx, UniProtKB:P00533] comment: Category=organism-sequence. synonym: "hEGFR/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "epidermal growth factor receptor isoform p110 (human)" EXACT [UniProtKB:P00533] xref: UniProtKB:P00533-3 is_a: PR:P00533 ! epidermal growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P00533 name: epidermal growth factor receptor (human) def: "An epidermal growth factor receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00533] comment: Category=organism-gene. synonym: "EGFR" RELATED Gene-based [UniProtKB:P00533] synonym: "ERBB" RELATED Gene-based [UniProtKB:P00533] synonym: "HER1" RELATED Gene-based [UniProtKB:P00533] synonym: "ERBB1" RELATED Gene-based [UniProtKB:P00533] synonym: "hEGFR" EXACT PRO-short-label [PRO:DNx] synonym: "proto-oncogene c-ErbB-1 (human)" EXACT [UniProtKB:P00533] synonym: "receptor tyrosine-protein kinase erbB-1 (human)" EXACT [UniProtKB:P00533] xref: DTO:03100124 xref: UniProtKB:P00533 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000006933 ! epidermal growth factor receptor relationship: has_gene_template HGNC:3236 ! EGFR (human) [Term] id: PR:P00533-1 name: epidermal growth factor receptor isoform 1 (human) def: "An epidermal growth factor receptor isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hEGFR/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "EGFR p170 (human)" EXACT [] xref: UniProtKB:P00533-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000027474 ! epidermal growth factor receptor isoform 1 [Term] id: PR:P00533-2 name: epidermal growth factor receptor isoform h2 (human) def: "An epidermal growth factor receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00533-2." [PRO:DNx, UniProtKB:P00533] comment: Category=organism-sequence. synonym: "hEGFR/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "epidermal growth factor receptor isoform p60 (human)" EXACT [UniProtKB:P00533] synonym: "epidermal growth factor receptor isoform TEGFR (human)" EXACT [UniProtKB:P00533] synonym: "epidermal growth factor receptor isoform Truncated (human)" EXACT [UniProtKB:P00533] xref: UniProtKB:P00533-2 is_a: PR:P00533 ! epidermal growth factor receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049849 name: epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified to include phosphorylated serines at the C-terminal tail, at positions 1070, 1071, 1081, and 1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10347170). Kinase=("CAMKII"; PR:000003197; Ser-1070/Ser-1071/Ser-1081/Ser-1166). Note: Ser-1166 is the major site of phosphorylation; this phosphorylation is involved in down-regulation of kinase activity. synonym: "hEGFR/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049852 name: epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphorylation at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, PR:000026291." [PMID:10347170, PRO:KER] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10347170). synonym: "hEGFR/SigPep-/UnPhos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210, Ser-768, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049850 name: epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphoserines at the C-terminal tail, at positions 1070, 1071, 1081, and 1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, PR:000026291." [PMID:10347170, PRO:KER] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10347170). synonym: "hEGFR/SigPep-/UnPhos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049851 name: epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human) def: "An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified on an inhibitory site located in the kinase domain (sub-kinase domain III) corresponding to a phosphoserine at position 768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046." [PMID:10347170, PRO:KER] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10347170). Kinase=("CAMKII"; PR:000003197; Ser-768). synonym: "hEGFR/SigPep-/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000028422 name: epidermal growth factor receptor, signal peptide removed form (human) def: "An epidermal growth factor receptor, signal peptide removed form in human. Example: UniProtKB:P00533-1, 25-1210." [PRO:DNx] comment: Category=organism-modification. synonym: "hEGFR/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016665" NARROW PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00533-1, 25-1210" NARROW PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-179837 "PR:000028422 located_in GO:0005886" xref: Reactome:R-HSA-9611160 "PR:000028422 located_in GO:0010008" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000019753 ! epidermal growth factor receptor, signal peptide removed form [Term] id: PR:000006933 name: epidermal growth factor receptor def: "An EGF receptor type tyrosine-protein kinase that is a translation product of the human EGFR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "EGFR" EXACT PRO-short-label [PRO:DNx] synonym: "ERBB" RELATED Gene-based [] synonym: "HER1" RELATED Gene-based [] synonym: "ERBB1" RELATED Gene-based [] synonym: "proto-oncogene c-ErbB-1" EXACT [] synonym: "receptor tyrosine-protein kinase erbB-1" EXACT [] xref: IUPHARobj:1797 is_a: PR:000001812 ! EGF receptor type tyrosine-protein kinase