[Term]
id: PR:D0Z5N4
name: eukaryotic translation initiation factor 2-alpha kinase gcn-2 (worm)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of worm." [OMA:D0Z5N4, PRO:DNx]
comment: Category=organism-gene.
synonym: "gcn-2" RELATED Gene-based [UniProtKB:D0Z5N4]
synonym: "Y81G3A.3" RELATED Gene-based [UniProtKB:D0Z5N4]
synonym: "EIF2AK4 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "general control nonderepressible kinase 2 (worm)" EXACT [UniProtKB:D0Z5N4]
xref: UniProtKB:D0Z5N4
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template WormBase:WBGene00013591 ! gcn-2 (worm)

[Term]
id: PR:D4A7V9
name: eIF-2-alpha kinase GCN2 (rat)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of rat." [OMA:D4A7V9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gcn2" RELATED Gene-based [UniProtKB:D4A7V9]
synonym: "Eif2ak4" RELATED Gene-based [UniProtKB:D4A7V9]
synonym: "rEIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "GCN2-like protein (rat)" EXACT [UniProtKB:D4A7V9]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 4 (rat)" EXACT [UniProtKB:D4A7V9]
xref: UniProtKB:D4A7V9
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template RGD:1311439 ! Eif2ak4 (rat)

[Term]
id: PR:Q9P2K8-1
name: eIF-2-alpha kinase GCN2 isoform h1 (human)
def: "An eIF-2-alpha kinase GCN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2K8-1." [PRO:DNx, UniProtKB:Q9P2K8]
comment: Category=organism-sequence.
synonym: "hEIF2AK4/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9P2K8-1
is_a: PR:Q9P2K8 ! eIF-2-alpha kinase GCN2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000006961
name: eIF-2-alpha kinase GCN2
def: "A protein that is a translation product of the human EIF2AK4 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GCN2" RELATED Gene-based []
synonym: "EIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA1338" RELATED Gene-based []
synonym: "GCN2-like protein" EXACT []
synonym: "eukaryotic translation initiation factor 2-alpha kinase 4" EXACT []
xref: IUPHARobj:2018
is_a: PR:000000001 ! protein

[Term]
id: PR:Q9P2K8-3
name: eIF-2-alpha kinase GCN2 isoform h3 (human)
def: "An eIF-2-alpha kinase GCN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2K8-3." [PRO:DNx, UniProtKB:Q9P2K8]
comment: Category=organism-sequence.
synonym: "hEIF2AK4/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9P2K8-3
is_a: PR:Q9P2K8 ! eIF-2-alpha kinase GCN2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9P2K8-2
name: eIF-2-alpha kinase GCN2 isoform h2 (human)
def: "An eIF-2-alpha kinase GCN2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9P2K8-2." [PRO:DNx, UniProtKB:Q9P2K8]
comment: Category=organism-sequence.
synonym: "hEIF2AK4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9P2K8-2
is_a: PR:Q9P2K8 ! eIF-2-alpha kinase GCN2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044810
name: eIF-2-alpha kinase GCN2 isoform 1 phosphorylated form (mouse)
def: "An eIF-2-alpha kinase GCN2 isoform 1 (mouse) that includes at least one phosphorylated residue. UniProtKB:Q9QZ05-1, MOD:00696." [PMID:18996085, PRO:KRC]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18996085). Note: PMID:18996085 shows by Northern blot that only the GCN2-beta isoform is present in oocytes, and by Western blot that the GCN2 protein present in oocytes is heavily phosphorylated.
synonym: "mEIF2AK4/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9QZ05-1, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "GCN2beta phosphorylated 1 (mouse)" EXACT []
is_a: PR:Q9QZ05-1 ! eIF-2-alpha kinase GCN2 isoform 1 (mouse)
relationship: has_part MOD:00696 ! phosphorylated residue
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9QZ05-1
name: eIF-2-alpha kinase GCN2 isoform 1 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-1." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 4 isoform GCN2beta (mouse)" EXACT [UniProtKB:Q9QZ05]
xref: UniProtKB:Q9QZ05-1
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9QZ05-3
name: eIF-2-alpha kinase GCN2 isoform m3 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-3." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha kinase GCN2 isoform GCN2gamma (mouse)" EXACT [UniProtKB:Q9QZ05]
xref: UniProtKB:Q9QZ05-3
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9QZ05-6
name: eIF-2-alpha kinase GCN2 isoform m6 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-6." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:m6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9QZ05-6
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9QZ05
name: eIF-2-alpha kinase GCN2 (mouse)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of mouse." [OMA:Q9QZ05, PRO:DNx]
comment: Category=organism-gene.
synonym: "Gcn2" RELATED Gene-based [UniProtKB:Q9QZ05]
synonym: "mGCN2" EXACT [UniProtKB:Q9QZ05]
synonym: "Eif2ak4" RELATED Gene-based [UniProtKB:Q9QZ05]
synonym: "Kiaa1338" RELATED Gene-based [UniProtKB:Q9QZ05]
synonym: "mEIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "GCN2-like protein (mouse)" EXACT [UniProtKB:Q9QZ05]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 4 (mouse)" EXACT [UniProtKB:Q9QZ05]
xref: UniProtKB:Q9QZ05
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template MGI:1353427 ! Eif2ak4 (mouse)

[Term]
id: PR:Q9QZ05-5
name: eIF-2-alpha kinase GCN2 isoform m5 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-5." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:m5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9QZ05-5
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9HGN1
name: eIF-2-alpha kinase GCN2 (Schizosaccharomyces pombe 972h-)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q9HGN1, PRO:DNx]
comment: Category=organism-gene.
synonym: "gcn2" RELATED Gene-based [UniProtKB:Q9HGN1]
synonym: "ppk28" RELATED Gene-based [UniProtKB:Q9HGN1]
synonym: "SPBC36B7.09" RELATED Gene-based [UniProtKB:Q9HGN1]
synonym: "SPBP18G5.01" RELATED Gene-based [UniProtKB:Q9HGN1]
synonym: "Spom972h-EIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase gcn2 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9HGN1]
synonym: "serine/threonine-protein kinase ppk28 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9HGN1]
xref: UniProtKB:Q9HGN1
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template PomBase:SPBC36B7.09 ! gcn2 (Schizosaccharomyces pombe)

[Term]
id: PR:D0Z5N4-1
name: eukaryotic translation initiation factor 2-alpha kinase gcn-2 isoform b (worm)
def: "A eukaryotic translation initiation factor 2-alpha kinase gcn-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D0Z5N4-1." [PRO:DNx, UniProtKB:D0Z5N4]
comment: Category=organism-sequence.
synonym: "EIF2AK4/iso:b (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:D0Z5N4-1
is_a: PR:D0Z5N4 ! eukaryotic translation initiation factor 2-alpha kinase gcn-2 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q9P2K8
name: eIF-2-alpha kinase GCN2 (human)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9P2K8]
comment: Category=organism-gene.
synonym: "GCN2" RELATED Gene-based [UniProtKB:Q9P2K8]
synonym: "EIF2AK4" RELATED Gene-based [UniProtKB:Q9P2K8]
synonym: "KIAA1338" RELATED Gene-based [UniProtKB:Q9P2K8]
synonym: "hEIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "GCN2-like protein (human)" EXACT [UniProtKB:Q9P2K8]
synonym: "eukaryotic translation initiation factor 2-alpha kinase 4 (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-9633007 "PR:Q9P2K8 located_in GO:0005829"
xref: DTO:03100121
xref: UniProtKB:Q9P2K8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template HGNC:19687 ! EIF2AK4 (human)

[Term]
id: PR:Q9QZ05-4
name: eIF-2-alpha kinase GCN2 isoform m4 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-4." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:m4" EXACT PRO-short-label [PRO:DNx]
synonym: "eIF-2-alpha kinase GCN2 isoform GCN2alpha (mouse)" EXACT [UniProtKB:Q9QZ05]
xref: UniProtKB:Q9QZ05-4
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:D0Z5N4-2
name: eukaryotic translation initiation factor 2-alpha kinase gcn-2 isoform a (worm)
def: "A eukaryotic translation initiation factor 2-alpha kinase gcn-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:D0Z5N4-2." [PRO:DNx, UniProtKB:D0Z5N4]
comment: Category=organism-sequence.
synonym: "EIF2AK4/iso:a (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:D0Z5N4-2
is_a: PR:D0Z5N4 ! eukaryotic translation initiation factor 2-alpha kinase gcn-2 (worm)
relationship: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans

[Term]
id: PR:Q9QZ05-2
name: eIF-2-alpha kinase GCN2 isoform m2 (mouse)
def: "An eIF-2-alpha kinase GCN2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9QZ05-2." [PRO:DNx, UniProtKB:Q9QZ05]
comment: Category=organism-sequence.
synonym: "mEIF2AK4/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9QZ05-2
is_a: PR:Q9QZ05 ! eIF-2-alpha kinase GCN2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P15442
name: eIF-2-alpha kinase GCN2 (yeast)
def: "An eIF-2-alpha kinase GCN2 that is encoded in the genome of yeast." [OMA:P15442, PRO:DNx]
comment: Category=organism-gene.
synonym: "AAS1" RELATED Gene-based [UniProtKB:P15442]
synonym: "GCN2" RELATED Gene-based [UniProtKB:P15442]
synonym: "YDR283C" RELATED Gene-based [UniProtKB:P15442]
synonym: "yEIF2AK4" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase GCN2 (yeast)" EXACT [UniProtKB:P15442]
synonym: "general control non-derepressible protein 2 (yeast)" EXACT [UniProtKB:P15442]
xref: UniProtKB:P15442
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000006961 ! eIF-2-alpha kinase GCN2
relationship: has_gene_template SGD:S000002691 ! GCN2 (yeast)

[Term]
id: PR:000046144
name: eIF-2-alpha kinase GCN2 phosphorylated 1 (yeast)
def: "An eIF-2-alpha kinase GCN2 (yeast) that has been phosphorylated at Ser-577. UniProtKB:P15442, Ser-577, MOD:00046." [PMID:12070158, iPTMnet:P15442]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12070158). Status=unreviewed.
synonym: "yEIF2AK4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P15442, Ser-577, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P15442 ! eIF-2-alpha kinase GCN2 (yeast)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C