[Term]
id: PR:Q9JHS1
name: endothelial PAS domain-containing protein 1 (rat)
def: "An endothelial PAS domain-containing protein 1 that is encoded in the genome of rat." [OMA:Q9JHS1, PANTHER:PTHR23043:SF8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Epas1" RELATED Gene-based [UniProtKB:Q9JHS1]
synonym: "Hif2a" RELATED Gene-based [UniProtKB:Q9JHS1]
synonym: "rEPAS1" EXACT PRO-short-label [PRO:DNx]
synonym: "EPAS-1 (rat)" EXACT [UniProtKB:Q9JHS1]
synonym: "HIF2-alpha (rat)" EXACT [UniProtKB:Q9JHS1]
synonym: "HIF-2-alpha (rat)" EXACT [UniProtKB:Q9JHS1]
synonym: "hypoxia-inducible factor 2-alpha (rat)" EXACT [UniProtKB:Q9JHS1]
xref: UniProtKB:Q9JHS1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000007106 ! endothelial PAS domain-containing protein 1
relationship: has_gene_template RGD:68404 ! Epas1 (rat)

[Term]
id: PR:000007106
name: endothelial PAS domain-containing protein 1
def: "A protein that is a translation product of the human EPAS1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HLF" BROAD [PRO:DNx]
synonym: "HRF" RELATED []
synonym: "MOP2" RELATED Gene-based []
synonym: "EPAS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HIF2A" RELATED Gene-based []
synonym: "PASD2" RELATED Gene-based []
synonym: "EPAS-1" EXACT []
synonym: "BHLHE73" RELATED Gene-based []
synonym: "bHLHe73" EXACT []
synonym: "HIF2-alpha" EXACT []
synonym: "HIF-2-alpha" EXACT []
synonym: "HIF-related factor" EXACT []
synonym: "HIF-1-alpha-like factor" EXACT []
synonym: "member of PAS protein 2" EXACT []
synonym: "PAS domain-containing protein 2" EXACT []
synonym: "hypoxia-inducible factor 2-alpha" EXACT []
synonym: "basic-helix-loop-helix-PAS protein MOP2" EXACT []
synonym: "class E basic helix-loop-helix protein 73" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q99814
name: endothelial PAS domain-containing protein 1 (human)
def: "An endothelial PAS domain-containing protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99814]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "MOP2" RELATED Gene-based [UniProtKB:Q99814]
synonym: "EPAS1" RELATED Gene-based [UniProtKB:Q99814]
synonym: "HIF2A" RELATED Gene-based [UniProtKB:Q99814]
synonym: "PASD2" RELATED Gene-based [UniProtKB:Q99814]
synonym: "hEPAS1" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHE73" RELATED Gene-based [UniProtKB:Q99814]
synonym: "HLF (human)" EXACT [UniProtKB:Q99814]
synonym: "EPAS-1 (human)" EXACT [UniProtKB:Q99814]
synonym: "HIF2-alpha (human)" EXACT [UniProtKB:Q99814]
synonym: "HIF-2-alpha (human)" EXACT [UniProtKB:Q99814]
synonym: "HIF-1-alpha-like factor (human)" EXACT [UniProtKB:Q99814]
synonym: "member of PAS protein 2 (human)" EXACT [UniProtKB:Q99814]
synonym: "PAS domain-containing protein 2 (human)" EXACT [UniProtKB:Q99814]
synonym: "hypoxia-inducible factor 2-alpha (human)" EXACT [UniProtKB:Q99814]
synonym: "basic-helix-loop-helix-PAS protein MOP2 (human)" EXACT [UniProtKB:Q99814]
synonym: "class E basic helix-loop-helix protein 73 (human)" EXACT [UniProtKB:Q99814]
xref: Reactome:R-HSA-452560 "PR:Q99814 located_in GO:0005654"
xref: Reactome:R-HSA-1234119 "PR:Q99814 located_in GO:0005829"
xref: UniProtKB:Q99814
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007106 ! endothelial PAS domain-containing protein 1
relationship: has_gene_template HGNC:3374 ! EPAS1 (human)

[Term]
id: PR:P97481
name: endothelial PAS domain-containing protein 1 (mouse)
def: "An endothelial PAS domain-containing protein 1 that is encoded in the genome of mouse." [OMA:P97481, PRO:DNx]
comment: Category=organism-gene.
synonym: "mHLF" RELATED [PRO:DAN, UniProtKB:P97481]
synonym: "Epas1" RELATED Gene-based [UniProtKB:P97481]
synonym: "Hif2a" RELATED Gene-based [UniProtKB:P97481]
synonym: "mEPAS1" EXACT PRO-short-label [PRO:DNx]
synonym: "HLF (mouse)" EXACT [UniProtKB:P97481]
synonym: "HRF (mouse)" EXACT [UniProtKB:P97481]
synonym: "EPAS-1 (mouse)" EXACT [UniProtKB:P97481]
synonym: "HIF2-alpha (mouse)" EXACT [UniProtKB:P97481]
synonym: "HIF-2-alpha (mouse)" EXACT [UniProtKB:P97481]
synonym: "HIF-related factor (mouse)" EXACT [UniProtKB:P97481]
synonym: "HIF-1-alpha-like factor (mouse)" EXACT [UniProtKB:P97481]
synonym: "hypoxia-inducible factor 2-alpha (mouse)" EXACT [UniProtKB:P97481]
xref: UniProtKB:P97481
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000007106 ! endothelial PAS domain-containing protein 1
relationship: has_gene_template MGI:109169 ! Epas1 (mouse)

[Term]
id: PR:000046039
name: endothelial PAS domain-containing protein 1 phosphorylated 1 (human)
def: "An endothelial PAS domain-containing protein 1 (human) that has been phosphorylated at Thr-324. UniProtKB:Q99814, Thr-324, MOD:00047." [PMID:17024177, iPTMnet:Q99814]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17024177). Status=unreviewed.
synonym: "hEPAS1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99814, Thr-324, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q99814 ! endothelial PAS domain-containing protein 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens