[Term]
id: PR:P21333-2
name: filamin-A isoform h2 (human)
def: "A filamin-A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21333-2." [PRO:DNx, UniProtKB:P21333]
comment: Category=organism-sequence.
synonym: "hFLNA/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21333-2
is_a: PR:P21333 ! filamin-A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045709
name: filamin-A phosphorylated 1 (human)
def: "A filamin-A (human) that has been phosphorylated on the residue at the position equivalent to Ser-2152 of the amino acid sequence represented by UniProtKB:P21333-1. Example: UniProtKB:P21333-1, Ser-2152, MOD:00046." [PMID:15024089, PMID:25944616, iPTMnet:P21333]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15024089, PMID:25944616). Status=unreviewed.
synonym: "hFLNA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P21333-1, Ser-2152, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P21333 ! filamin-A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P21333-1
name: filamin-A isoform h1 (human)
def: "A filamin-A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21333-1." [PRO:DNx, UniProtKB:P21333]
comment: Category=organism-sequence.
synonym: "hFLNA/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P21333-1
is_a: PR:P21333 ! filamin-A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000007555
name: filamin-A
def: "A protein that is a translation product of the human FLNA gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FLN" RELATED Gene-based []
synonym: "FLN1" RELATED Gene-based []
synonym: "FLNA" EXACT PRO-short-label [PRO:DNx]
synonym: "FLN-A" EXACT []
synonym: "ABP-280" EXACT []
synonym: "filamin-1" EXACT []
synonym: "alpha-filamin" EXACT []
synonym: "non-muscle filamin" EXACT []
synonym: "actin-binding protein 280" EXACT []
synonym: "endothelial actin-binding protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P21333
name: filamin-A (human)
def: "A filamin-A that is encoded in the genome of human." [PRO:DNx, UniProtKB:P21333]
comment: Category=organism-gene.
synonym: "FLN" RELATED Gene-based [UniProtKB:P21333]
synonym: "FLN1" RELATED Gene-based [UniProtKB:P21333]
synonym: "FLNA" RELATED Gene-based [UniProtKB:P21333]
synonym: "hFLNA" EXACT PRO-short-label [PRO:DNx]
synonym: "FLN-A (human)" EXACT [UniProtKB:P21333]
synonym: "ABP-280 (human)" EXACT [UniProtKB:P21333]
synonym: "filamin-1 (human)" EXACT [UniProtKB:P21333]
synonym: "alpha-filamin (human)" EXACT [UniProtKB:P21333]
synonym: "non-muscle filamin (human)" EXACT [UniProtKB:P21333]
synonym: "actin-binding protein 280 (human)" EXACT [UniProtKB:P21333]
synonym: "endothelial actin-binding protein (human)" EXACT [UniProtKB:P21333]
xref: UniProtKB:P21333
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007555 ! filamin-A
relationship: has_gene_template HGNC:3754 ! FLNA (human)

[Term]
id: PR:000047426
name: filamin-A, initiator methionine removed phosphorylated 1 (human)
def: "A filamin-A (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 2152 of the amino acid sequence represented by UniProtKB:P21333. UniProtKB:P21333, 2-2647, Ser-2152, MOD:00046." [PRO:DNx, Reactome:R-HSA-5669246]
comment: Category=organism-modification.
synonym: "hFLNA/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000087296, Ser-2152, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P21333, 2-2647, Ser-2152, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5669246 "PR:000047426 located_in GO:0005829"
is_a: PR:P21333 ! filamin-A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047425
name: filamin-A, initiator methionine removed form (human)
def: "A filamin-A (human) that has had the initiator methionine removed. UniProtKB:P21333, 2-2647." [PRO:DNx, Reactome:R-HSA-210019, Reactome:R-HSA-350712]
comment: Category=organism-modification.
synonym: "PRO_0000087296" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hFLNA/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P21333, 2-2647" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-210019 "PR:000047425 located_in GO:0005829"
xref: Reactome:R-HSA-350712 "PR:000047425 located_in GO:0005576"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P21333 ! filamin-A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens