[Term] id: PR:000007569 name: formin-1 def: "A protein that is a translation product of the human FMN1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "LD" RELATED Gene-based [] synonym: "FMN" RELATED Gene-based [] synonym: "FMN1" EXACT PRO-short-label [PRO:DNx] synonym: "limb deformity protein" EXACT [] synonym: "limb deformity protein homolog" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:Q05860-2 name: formin-1 isoform 2 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-2." [PMID:8516300, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:8516300, the amino acid sequences of five formin isoforms were predicted from cDNA sequences and each was produced by in vitro transcription and translation to characterize the apparent molecular masses by SDS-PAGE. synonym: "mFMN1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (IB)" EXACT [] synonym: "formin-1 IB (mouse)" EXACT [] xref: UniProtKB:Q05860-2 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q05860-3 name: formin-1 isoform 3 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-3." [PMID:8516300, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:8516300, the amino acid sequences of five formin isoforms were predicted from cDNA sequences and each was produced by in vitro transcription and translation to characterize the apparent molecular masses by SDS-PAGE. synonym: "mFMN1/iso:3" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (II)" EXACT [] synonym: "formin-1 II (mouse)" EXACT [] xref: UniProtKB:Q05860-3 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q05860-1 name: formin-1 isoform 1 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-1." [PMID:8516300, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:8516300, the amino acid sequences of five formin isoforms were predicted from cDNA sequences and each was produced by in vitro transcription and translation to characterize the apparent molecular masses by SDS-PAGE. synonym: "mFMN1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (IA)" EXACT [] synonym: "formin-1 IA (mouse)" EXACT [] xref: UniProtKB:Q05860-1 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q05860-6 name: formin-1 isoform 6 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-6." [PMID:14647292, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:14647292, using the yeast two-hybrid system with alpha-catenin as the bait isolated two independent formin1 clones, one corresponding to formin-1 (IV) and the other a novel transcript called formin-1 (V). synonym: "mFMN1/iso:6" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (V)" EXACT [] synonym: "formin-1 V (mouse)" EXACT [] xref: UniProtKB:Q05860-6 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q05860-4 name: formin-1 isoform 4 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-4." [PMID:8516300, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:8516300, the amino acid sequences of five formin isoforms were predicted from cDNA sequences and each was produced by in vitro transcription and translation to characterize the apparent molecular masses by SDS-PAGE. synonym: "mFMN1/iso:4" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (III)" EXACT [] synonym: "formin-1 III (mouse)" EXACT [] xref: UniProtKB:Q05860-4 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q05860-5 name: formin-1 isoform 5 (mouse) def: "A formin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q05860-5." [PMID:14647292, PMID:8516300, PRO:KRC] comment: Category=organism-sequence. Note: In PMID:8516300, the amino acid sequences of five formin isoforms were predicted from cDNA sequences and each was produced by in vitro transcription and translation to characterize the apparent molecular masses by SDS-PAGE. The mRNA for isoform IV was also detected in NIH 3T3 cells and primary fibroblast cells and can also be immunoprecipitated from these cells. In PMID:14647292, using the yeast two-hybrid system with alpha-catenin as the bait isolated two independent formin1 clones, one corresponding to formin-1 (IV) and the other a novel transcript called formin-1 (V). synonym: "mFMN1/iso:5" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 (IV)" EXACT [] synonym: "formin-1 IV (mouse)" EXACT [] xref: UniProtKB:Q05860-5 is_a: PR:Q05860 ! formin-1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q68DA7-5 name: formin-1 isoform h5 (human) def: "A formin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q68DA7-5." [PRO:DNx, UniProtKB:Q68DA7] comment: Category=organism-sequence. synonym: "hFMN1/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q68DA7-5 is_a: PR:Q68DA7 ! formin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q68DA7-2 name: formin-1 isoform h2 (human) def: "A formin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q68DA7-2." [PRO:DNx, UniProtKB:Q68DA7] comment: Category=organism-sequence. synonym: "hFMN1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q68DA7-2 is_a: PR:Q68DA7 ! formin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037436 name: formin-1 isoform 5 phosphoserine (+/- phosphothreonine) form (mouse) def: "A formin-1 isoform 5 (mouse) that has been phosphorylated on some Ser and possibly some Thr residues, but not on Tyr residues. UniProtKB:Q05860-5, MOD:00046 and/or MOD:00047." [PMID:14647292, PMID:8516300, PRO:KRC] comment: Category=organism-modification. Note: In PMID:8516300, primary wild-type fibroblast cell lines were labeled with 32P, followed by immunoprecipitation with anti-formin peptide antisera and immunoprecipitated isoform IV was phospholabeled (Fig 3A). TLC phosphoamino acid analysis of formin IV transiently overexpressed in COS cells and immunoprecipitated demonstrated phosphorylation of serine and possibly threonine but no detectable labeling of tyrosine (Fig. 3C). synonym: "mFMN1/iso:5/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "formin-1 IV phosphorylated 1" EXACT [] synonym: "formin-1 (IV) phosphorylated 1" EXACT [] synonym: "UniProtKB:Q05860-5, MOD:00046 and/or MOD:00047" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:Q05860-5 ! formin-1 isoform 5 (mouse) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q68DA7-3 name: formin-1 isoform h3 (human) def: "A formin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q68DA7-3." [PRO:DNx, UniProtKB:Q68DA7] comment: Category=organism-sequence. synonym: "hFMN1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q68DA7-3 is_a: PR:Q68DA7 ! formin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q68DA7-1 name: formin-1 isoform h1 (human) def: "A formin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q68DA7-1." [PRO:DNx, UniProtKB:Q68DA7] comment: Category=organism-sequence. synonym: "hFMN1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q68DA7-1 is_a: PR:Q68DA7 ! formin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q05860 name: formin-1 (mouse) def: "A formin-1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-gene. synonym: "Ld" RELATED Gene-based [UniProtKB:Q05860] synonym: "Fmn" RELATED Gene-based [UniProtKB:Q05860] synonym: "Fmn1" RELATED Gene-based [UniProtKB:Q05860] synonym: "mFMN1" EXACT PRO-short-label [PRO:DNx] synonym: "limb deformity protein (mouse)" EXACT [UniProtKB:Q05860] xref: UniProtKB:Q05860 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000007569 ! formin-1 relationship: has_gene_template MGI:101815 ! Fmn1 (mouse) [Term] id: PR:Q68DA7 name: formin-1 (human) def: "A formin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q68DA7] comment: Category=organism-gene. synonym: "LD" RELATED Gene-based [UniProtKB:Q68DA7] synonym: "FMN" RELATED Gene-based [UniProtKB:Q68DA7] synonym: "FMN1" RELATED Gene-based [UniProtKB:Q68DA7] synonym: "hFMN1" EXACT PRO-short-label [PRO:DNx] synonym: "limb deformity protein homolog (human)" EXACT [UniProtKB:Q68DA7] xref: UniProtKB:Q68DA7 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007569 ! formin-1 relationship: has_gene_template HGNC:3768 ! FMN1 (human)